Effect of Hyssopus officinalis leaves alcoholic extract on motor neuron density in anterior horn after sciatic nerve compression in rats

Background and Objective: The degeneration of motor neuron in anterior horn of spinal cord can be caused by compression. Hyssopus officinalis of Laminacea family demonstrate antioxidant and anti-inflammation effects. This study was done to evaluate the effect of alcoholic extract of Hyssopus officinalis leaves, on motor neuron in spinal cord after sciatic nerve compression in male rats. Methods: In this experimental research, 60 male wistar rats were randomly allocated into six groups including; control, compression, and compression + treatment (25, 50, 75, 100 mg/kg/bw). In order to induce compression, sciatic nerve of right leg was exposed to compression for 60 second using locker pincers. Extract injected intraperitoneally in the first and second week after compression. 28 days after compression under profusion method, the lumber spinal cord was sampled. The density of motor neurons (9-20 micron) was measured using dissector and stereological method. Results: Density of neurons in compression group (611±34) significantly reduced compared to the control group (1658±30) (P<0.05). Moreover, neuronal density was significantly increased in 25 (1179±22), 50 (1260±20), 75 (1350±15) and 100 (1120±10) mg/kg/bw doses in treatment groups in compared to the compression group (P<0.05). Conclusion: Alcoholic extract of Hyssopus officinalis leaves exhibite neuroprotective effect on neurons in anterior horn of the spinal cord after injury. This effect probably is related to the antioxidant and anti inflammation properties in alcoholic extract of Hyssopus officinalis, dose dependly

Catalytic synthesis of warfarin acetals by using different heteropolyacid catalysts

In this research, we report on the synthesis of warfarin acetals by using Preyssler's anion, [NaP5W30O110]-14 and heteropolyacids (HPAs) catalysts. This reaction was performed using methanol and ethanol at reflux temperature conditions. Under these conditions we have excellent yields and high selectivity. Preyssler heteropolyacid catalyst were easily recycled recovery and reused without the loss of its catalytic activities. The synthesis of warfarin acetals has been achieved using the catalytic amounts of green, inexpensive and eco-friendly Keggin types heteropolyacids. The products were obtained in high yields

Synthesis of (s)-(-)-propranolol by using cs2.5h0.5pw12o40 nanocatalyst as green, eco-friendly, reusable, and recyclable catalyst

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Catalytic synthesis of warfarin acetals by using different heteropolyacid catalysts

In this research, we report on the synthesis of warfarin acetals by using Preyssler's anion, [NaP5W30O110]-14 and heteropolyacids (HPAs) catalysts. This reaction was performed using methanol and ethanol at reflux temperature conditions. Under these conditions we have excellent yields and high selectivity. Preyssler heteropolyacid catalyst were easily recycled recovery and reused without the loss of its catalytic activities. The synthesis of warfarin acetals has been achieved using the catalytic amounts of green, inexpensive and eco-friendly Keggin types heteropolyacids. The products were obtained in high yields

Heteropolyacids accelerated multi-component synthesis of n-phenylquinazolin-4-amines by using silica-supported preyssler nanoparticles in green solvent

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Performance evaluation of wavelet SVD-based watermarking schemes for color images

Digital image watermarking techniques have enabled imperceptible information in images to be hidden to ensure the information can be extracted later from those images. For any watermarking scheme, there are four main requirements which are imperceptibility, Robustness, capacity and security. Recently, hybrid Singular Value Decomposition (SVD) based watermarking schemes in the transform domain have significantly gained a lot of attention. This is due to the characteristics of SVD and the wavelet. Most of these schemes were tested under different conditions using grey images only. However, due to the growth of digital technology and the huge use of the colour images, it is important to consider the colour images in the watermarking area. Three different SVD-based image watermarking schemes with different wavelet transforms are selected in this paper to be tested and evaluated for colour images. Two colour models are used to represent the colour images to perform the embedding and the extraction watermarking process to study these colour models’ performances and effectiveness in the watermarking area. These colour models are RGB and YCbCr. All these colour models’ channels are used as an embedding channel and then are evaluated under different attacks types. The experimental results of the selected Wavelet SVD-based watermarking schemes proved that the embedding in the RGB and YCbCr colour channels are achieved high imperceptibility. These colour channels also showed good robustness against different attacks such as cropping, cutting, rotation and JPEG compression

Novel point mutations in cyp51A and cyp51B genes associated with itraconazole and posaconazole resistance in aspergillus clavatus isolates

Aspergillus clavatus is a common environmental species known to cause occupational allergic disease in grain handlers. We have recently observed azole-resistant isolates of this fungus as a cause of onychomycosis. To further characterize the cause of resistance, the genes encoding 14 α-sterol demethylase enzyme (cyp51A and cyp51B) were characterized and analyzed in 9 ITC-susceptible isolates and 6 isolates with high minimum inhibitory concentrations (MICs) of clinical (nail and sputum) and environmental A. clavatus strains. We found that six isolates with itraconazole MIC >16 mg/L demonstrated nonsynonymous mutations, including V51I, L378P, E483K, and E506G, and synonymous mutations, including F53F, A186A, Q276Q, and H359H. Moreover, P486S was detected in five strains with ITR MIC >16 mg/L. One mutation, F324S, was detected in an isolate with posaconazole MIC >16 mg/L. The effect of E483K and P486S mutations of CYP51A on azole resistance was further investigated using homology modeling and molecular dynamics. We found that E483K and P486S mutations were located near the ligand access channel of CYP51A that could partly lead to narrowing the entry of the ligand access channels. Therefore, we concluded that E483K and P486S mutations may potentially contribute to the limited access of inhibitors to the binding pocket and therefore confer resistance to azole agents. © 2019 Mary Ann Liebert, Inc., publishers