Applied investigation of person-specific and context-specific factors on postoperative recovery and clinical outcomes of patients undergoing gastrointestinal cancer surgery: multicentre European study

INTRODUCTION: Cancer treatments have greatly advanced over the past two decades causing survival improvements and reduced complications from cancer surgery. However, the cancer diagnosis and the effects of treatment modalities pose a major risk to patients' psychological well-being. Given current interest and emerging evidence about the importance of psychological and social factors on cancer survival and coping with cancer treatments, this study will build and expand research in order to identify key modifiable psychosocial variables that contribute to better physical and mental health following gastrointestinal cancer (GIC) surgery. OBJECTIVES: To elucidate the incidence of postoperative psychiatric morbidity within 6 months following GIC surgery. To identify key measurable modifiable preoperative psychological factors that can significantly affect postoperative psychiatric morbidity in patients undergoing surgery for GIC. To clarify the changes seen in a patient's psychological well-being during their treatment pathway for GIC. METHODS AND ANALYSIS: This multicentre study has an observational longitudinal study design. In total, 1000 patients will be screened with a multicomponent psychological questionnaire at four different time points: at diagnosis, preoperatively, 1 and 6 months after surgery. Data from this questionnaire will be linked to postoperative complications including psychiatric morbidity, length of hospital stay and recovery to normal activity. ETHICS AND DISSEMINATION: NHS Health Research Authority approval was gained on (REC reference 15.LO/1847) for the completion of this study. Multiple platforms will be used for the dissemination of the research data, including international clinical and patient group presentations and publication of research outputs in a high impact clinical journal

Comparison of Oxygen Adsorption and Platinum Dissolution in Acid and Alkaline Solutions Using Electrochemical Quartz Crystal Microbalance

Platinum (Pt) is a widely used electrocatalyst material in fuel cells and electrolysers. Proton exchange membrane (PEM) fuel cells and electrolysis operate under highly acidic conditions whereas the more recently developed anion exchange membrane (AEM) processes take place under alkaline conditions. Pt dissolution and Pt oxidation during operation and varying potentials has been studied mainly for the acidic PEM and less for the alkaline AEM. This study presents a comparison of Pt dissolution and Pt oxidation in 0.5 M H2SO4 and 1 M KOH using electrochemical quartz crystal microbalance (EQCM) on Pt thin films. Physical characterisation using electron microscopy and atomic force microscopy (AFM) revealed small, yet significant differences in the Pt film surface structure, which is related to differences in measured electrochemical surface area (ECSA). The mass increase from adsorption of oxygenated species and Pt oxidation is higher in alkaline conditions compared to in acid while dissolution of Pt is similar

Oxygen reduction reaction kinetics on a Pt thin layer electrode in AEMFC

The study of the catalytic activity in a fuel cell is challenging, as mass transport, gas crossover and the counter electrode are generally interfering. In this study, a Pt electrode consisting of a thin film deposited on the gas diffusion layer was employed to study the oxygen reduction reaction (ORR) in an operating Anion Exchange Membrane Fuel Cell (AEMFC). The 2D Pt electrode was assembled together with a conventional porous Pt/C counter electrode and an extra Pt/C layer and membrane to reduce the H2 crossover. Polarization curves at different O2 partial pressures were recorded and the resulting reproducible ORR activities were normalized with respect to the active surface area (ECSA), obtained by CO stripping. As expected, decreasing the O2 partial pressure results in a negative shift in open circuit voltage (OCV), cell voltage and maximum attainable current density. For cell voltages above 0.8 V a fairly constant Tafel slope of 60 mV dec−1 was recorded but at lower voltages the slope increases rapidly. The observed Tafel slope can be explained by a theoretical model with an associative mechanism where charge- and proton-transfer steps are decoupled, and the proton transfer is the rate-determining step. A reaction order of 1 with respect to O2 was obtained at 0.65 V which corresponds well with the mechanism suggested above. Based on the obtained catalyst activities, the electrode performance is comparable to good porous electrodes found in the field. The methodology presented in this study is expected to be useful in future kinetic studies of other catalysts for AEMFC

Enhanced oxygen reduction activity with rare earth metal alloy catalysts in proton exchange membrane fuel cells

Alloying platinum is an approach to increase the oxygen reduction reaction (ORR) activity and at the same time reduce the amount of precious platinum catalyst in proton exchange membrane fuel cells (PEMFC). In this work the cathode activity of thin films of rare earth metals (REM) alloys, Pt Y, Pt Gd and Pt Tb, produced by sputter deposition onto gas diffusion layers, are evaluated in a fuel cell by means of polarization curves in O /H , and cyclic- and CO-stripping voltammetry in N /5% H . Prior to evaluation, the model electrodes were acid-treated to obtain a Pt skin covering the PtREM alloy bulk, as was revealed by energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). The core shell alloys of Pt Y and Pt Gd catalysts show a specific activity enhancement at 0.9 V of 2.5 times compared to pure Pt. The slightly lower enhancement factor of 2.0 for Pt Tb is concluded to be due to leaching of the REM, that resulted in a thicker, and subsequently less strained, Pt overlayer. The high activity, combined with the minor changes in surface composition, achieved in the fuel cell environment shows that PtREM core shell catalysts are promising for the cathode reaction in PEMFC

Magnetic moments of 2 1 + states in 124,126,128 Sn

The g factors of the first-excited states of stable 124Sn and radioactive 126,128Sn were measured by the recoil-in-vacuum method with comparatively high precision. The experiments were performed at the Holifield Radioactive Ion Beam Facility by Coulomb e

Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma: A Pooled Analysis from the BEACON Consortium.

BACKGROUND: The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute. METHODS: This genetic-epidemiological study pooled 14 studies from three continents, Australia, Europe, and North America. Polymorphisms in 3 key genes coding for the oestrogen pathway (receptor alpha (ESR1), receptor beta (ESR2), and aromatase (CYP19A1)), and 3 key genes of the oxytocin pathway (the oxytocin receptor (OXTR), oxytocin protein (OXT), and cyclic ADP ribose hydrolase glycoprotein (CD38)), were analysed using a gene-based approach, versatile gene-based test association study (VEGAS). RESULTS: Among 1508 OAC patients, 2383 BO patients, and 2170 controls, genetic variants within ESR1 were associated with BO in males (p = 0.0058) and an increased risk of OAC and BO combined in males (p = 0.0023). Genetic variants within OXTR were associated with an increased risk of BO in both sexes combined (p = 0.0035) and in males (p = 0.0012). We followed up these suggestive findings in a further smaller data set, but found no replication. There were no significant associations between the other 4 genes studied and risk of OAC, BO, separately on in combination, in males and females combined or in males only. CONCLUSION: Genetic variants in the oestrogen receptor alpha and the oxytocin receptor may be associated with an increased risk of BO or OAC, but replication in other large samples are needed

Reproductive factors and oesophageal cancer in Chinese women: a case-control study

<p/> <p>Background</p> <p>Previous studies showed that sex hormone might play a role in the development of oesophageal cancer in Western countries. However, evidence from Chinese populations is still lacking.</p> <p>Methods</p> <p>We performed a hospital-based case-control study in Guangzhou, China. From June 2006 to May 2009, face-to-face interviews were conducted on 73 cases and 157 controls. Cases were Chinese females with newly diagnosed primary oesophageal cancer. Controls were hospitalized individuals without cancer and frequency matched by age groups. The interviews included questions about childbearing and menarche history, together with potential confounders. Unconditional logistic regression was used to estimate the risk of factors.</p> <p>Results</p> <p>Women who had given birth before were not at increased risk compared to childless women (adjusted OR = 1.17, 95% CI: 0.48 ~ 2.85). The risk of oesophageal cancer increased with age at first birth: the adjusted OR for women first giving birth at age 25 or later was 2.02 (95% CI: 1.01 ~ 4.04) compared with those reporting their first birth before age 22. History of spontaneous abortion was not significantly associated with increased risk (adjusted OR = 1.37, 95% CI: 0.49 ~ 3.83). No significant association was observed between menstrual variables (age at menarche, age at menopause, and years of menstruation) and risk of oesophageal cancer.</p> <p>Conclusions</p> <p>Giving birth at later age may increase the risk of oesophageal cancer in women. Further studies in Chinese populations with larger sample sizes are still needed.</p

Orbifold projection in supersymmetric QCD at N_f\leq N_c

Supersymmetric orbifold projection of N=1 SQCD with relatively small number of flavors (not larger than the number of colors) is considered. The purpose is to check whether orbifolding commutes with the infrared limit. On the one hand, one considers the orbifold projection of SQCD and obtains the low-energy description of the resulting theory. On the other hand, one starts with the low-energy effective theory of the original SQCD, and only then perfoms orbifolding. It is shown that at finite N_c the two low-energy theories obtained in these ways are different. However, in the case of stabilized run-away vacuum these two theories are shown to coincide in the large N_c limit. In the case of quantum modified moduli space, topological solitons carrying baryonic charges are present in the orbifolded low-energy theory. These solitons may restore the correspondence between the two theories provided that the soliton mass tends to zero in the large N_c limit.Comment: 10 pages; misprint corrected, reference adde