Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

Demonstration of planar thick InP layers by selective MOVPE

a b s t r a c t We studied the selective metal-organic vapor-phase epitaxy of thick InP bulk layers. The work focused on the obtention of planar thick layers by an adjustment of the growth conditions. We showed that reduced pressure and temperature in the reactor allowed to decrease the sharpness of the thickness profiles in the vicinity of the mask. This approach is consistent with the vapor phase diffusion model and the kinetic theory. Thick InP layers generally show huge overgrowths at the edges of the dielectric stripes. These overgrowths were suppressed by reducing the growth rate. All samples' thickness profiles were characterized by means of optical interferometer microscopy and surface profiler. Scanning electronic microscopy was used in the observation of the edge overgrowths and highlighted the complexity and anisotropy of the growth at these edges

Revisiting the Relationship between Micro and Macro Social Work Practice

This analysis seeks to bridge the differences between micro and macro practice within the context of the shared mission of social work. The search for common ground, given decades of specialization, includes the identification of the different ways that the two forms of practice can inform each other, describes core workplace skills relevant to interventions at the micro and macro levels of organizational and community life, and explores the need for bilingual capacities to enhance communications between both domains of social work practice. It concludes with implications for future curricular changes