A publication database for optical long baseline interferometry

Optical long baseline interferometry is a technique that has generated almost 850 refereed papers to date. The targets span a large variety of objects from planetary systems to extragalactic studies and all branches of stellar physics. We have created a database hosted by the JMMC and connected to the Optical Long Baseline Interferometry Newsletter (OLBIN) web site using MySQL and a collection of XML or PHP scripts in order to store and classify these publications. Each entry is defined by its ADS bibcode, includes basic ADS informations and metadata. The metadata are specified by tags sorted in categories: interferometric facilities, instrumentation, wavelength of operation, spectral resolution, type of measurement, target type, and paper category, for example. The whole OLBIN publication list has been processed and we present how the database is organized and can be accessed. We use this tool to generate statistical plots of interest for the community in optical long baseline interferometry.Comment: To be published in the SPIE'2010 conference on "Optical and Infrared Interferometry II

The third version of the AMBER data reduction software

We present the third release of the AMBER data reduction software by the JMMC. This software is based on core algorithms optimized after several years of operation. An optional graphic interface in a high level language allows the user to control the process step by step or in a completely automatic manner. Ongoing improvement is the implementation of a robust calibration scheme, making use of the full calibration sets available during the night. The output products are standard OI-FITS files, which can be used directly in high level software like model fitting or image reconstruction tools. The software performances are illustrated on a full data set of calibrators observed with AMBER during 5 years taken in various instrumental setup.Comment: To be published in the proceedings of the SPIE'2010 conference on "Optical and Infrared Interferometry II

Building the 'JMMC Stellar Diameters Catalog' using SearchCal

11 pages, to be published in SPIE'2010 conference on "Optical and Infrared Interferometry II"The JMMC Calibrator Workgroup has long developed methods to ascertain the angular diameter of stars, and provides this expertise in the SearchCal software. SearchCal dynamically finds calibrators near science objects by querying CDS hosted catalogs according to observational parameters. Initially limited to bright objects (K magnitude ≤ 5.5), it has been upgraded with a new method providing calibrators without any magnitude limit but those of queried catalogs. We introduce here a new static catalog of stellar diameters, containing more than 38000 entries, obtained from SearchCal results aggregation on the whole celestial sphere, complete for all stars with HIPPARCOS parallaxes. We detail the methods and tools used to produce and study this catalog, and compare the static catalog approach with the dynamical querying provided by SearchCal engine. We also introduce a new Virtual Observatory service, enabling the reporting of, and querying about, stars flagged as "bad calibrators" by astronomers, adding this ever-growing database to our SearchCal service

LITpro: a model fitting software for optical interferometry

9 pagesInternational audienceLITpro is a software for fitting models on data obtained from various stellar optical interferometers, like the VLTI. As a baseline, for modeling the object, it provides a set of elementary geometrical and center-to-limb darkening functions, all combinable together. But it is also designed to make very easy the implementation of more specific models with their own parameters, to be able to use models closer to astrophysical considerations. So LITpro only requires the modeling functions to compute the Fourier transform of the object at given spatial frequencies, and wavelengths and time if needed. From this, LITpro computes all the necessary quantities as needed (e.g. visibilities, spectral energy distribution, partial derivatives of the model, map of the object model). The fitting engine, especially designed for this kind of optimization, is based on a modified Levenberg-Marquardt algorithm and has been successfully tested on real data in a prototype version. It includes a Trust Region Method, minimizing a heterogeneous non-linear and non-convex criterion and allows the user to set boundaries on free parameters. From a robust local minimization algorithm and a starting points strategy, a global optimization solution is effectively achieved. Tools have been developped to help users to find the global minimum. LITpro is also designed for performing fitting on heterogeneous data. It will be shown, on an example, how it fits simultaneously interferometric data and spectral energy distribution, with some benefits on the reliability of the solution and a better estimation of errors and correlations on the parameters. That is indeed necessary since present interferometric data are generally multi-wavelengths

The MAORY first-light adaptive optics module for E-ELT

The MAORY adaptive optics module is part of the first light instrumentation suite for the E-ELT. The MAORY project phase B is going to start soon. This paper contains a system-level overview of the current instrument design

MAORY for ELT: preliminary design overview

MAORY is one of the approved instruments for the European Extremely Large Telescope. It is an adaptive optics module, enabling high-angular resolution observations in the near infrared by real-time compensation of the wavefront distortions due to atmospheric turbulence and other disturbances such as wind action on the telescope. An overview of the instrument design is given in this paper

Zwischenbericht I der Intervallstudie 'Junge Arbeiter' 1. Erhebung 1968 fuer den VEB Schwermaschinenbau 'Kirow' Leipzig, Naumburgerstrasse

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Carbon ions Versus γ-Irradiation: The Telomeric Effect in Cancer Cells

International audienceThe higher biological effect of Carbon ions hadrontherapy (C+) is explained by the nature of the DNA damages. It is known that cell response to γ-irradiation (γ-IR), but not to C+, is correlated with telomere length in different type of cancer cells. Here, we propose that this " telomeric effect " must result from an effect of ROS in γ-IR compared to C+

Cellular and molecular portrait of eleven human glioblastoma cell lines irradiated with photons or carbon ions

International audienceThe multiform glioblastoma (GBM) is a heterogeneous and highly invasive entity, making it the most aggressive brain tumor. The standard-of-care for glioblastoma consists of surgical resection, radiotherapy and chemotherapy, but despite the recent improvement of therapeutic protocols, the recurrence seems inevitable. Due to a better dose localization in the tumor volume and a greater Relative Biological Efficiency (RBE), carbon ion therapy seems to be a promising alternative to conventional radiotherapy. However, to optimize individual treatment by hadrontherapy the exact carbon equivalent dose needs to be determined from data obtained after photon irradiation. Therefore, molecular and cellular investigations of GBM are required in order to improve the prediction and treatment of brain tumors. In this study, we have examined the radiobiological features of 11 human glioma cell lines displaying gradual radiosensitivity, following photon- or carbon-therapy in order to optimize and secure antiglioma strategies. Independent of p53 or O6-methylguanine-DNA methyltransferase (MGMT) status, all cell lines respond to both types of radiation by a G2/M phase arrest followed by the appearance of mitotic catastrophe, which is concluded by a ceramide-dependent-apoptotic cell death. Statistical analyses demonstrate that: (i) the surviving fraction at 2Gy (SF2) and the dose for 10% survival (D10) photon values are correlated with that obtained in response to carbon ions; (ii) regardless of p53, MGMT status, and radiosensitivity, the release of ceramide is associated with the induction of late apoptosis; (iii) the appearance of polyploid cells after photon irradiation could predict the RBE to carbon ions.The present study clearly provides a consistent database of the cellular and molecular response of glioblastoma cell lines to photon irradiation, and to the best of our knowledge represents the largest archive for carbon ion hadrontherapy response of glioblastoma cells. This type of archive is intended to customize the treatment of patients by allowing the development of new predictive mathematical models for the response of tumors to radiation, and ultimately could improve hadrontherapy treatment plans