278 research outputs found
On formal verification of arithmetic-based cryptographic primitives
Cryptographic primitives are fundamental for information security: they are
used as basic components for cryptographic protocols or public-key
cryptosystems. In many cases, their security proofs consist in showing that
they are reducible to computationally hard problems. Those reductions can be
subtle and tedious, and thus not easily checkable. On top of the proof
assistant Coq, we had implemented in previous work a toolbox for writing and
checking game-based security proofs of cryptographic primitives. In this paper
we describe its extension with number-theoretic capabilities so that it is now
possible to write and check arithmetic-based cryptographic primitives in our
toolbox. We illustrate our work by machine checking the game-based proofs of
unpredictability of the pseudo-random bit generator of Blum, Blum and Shub, and
semantic security of the public-key cryptographic scheme of Goldwasser and
Micali.Comment: 13 page
Effect of a therapeutic exercise program (FisioPausa) on the quality of life of employees from CESPU
Introduction In the context of work, labouring time is mainly spent in the sitting position and in a continuous way. This reality contributes for the increase of a sedentary lifestyle of workers, leading to health-related diseases and consequently decreasing they quality of life (QoL).info:eu-repo/semantics/publishedVersio
Meningitis Dipstick Rapid Test: Evaluating Diagnostic Performance during an Urban Neisseria meningitidis Serogroup A Outbreak, Burkina Faso, 2007
Meningococcal meningitis outbreaks occur every year during the dry season in the “meningitis belt” of sub-Saharan Africa. Identification of the causative strain is crucial before launching mass vaccination campaigns, to assure use of the correct vaccine. Rapid agglutination (latex) tests are most commonly available in district-level laboratories at the beginning of the epidemic season; limitations include a short shelf-life and the need for refrigeration and good technical skills. Recently, a new dipstick rapid diagnostic test (RDT) was developed to identify and differentiate disease caused by meningococcal serogroups A, W135, C and Y. We evaluated the diagnostic performance of this dipstick RDT during an urban outbreak of meningitis caused by N. meningitidis serogroup A in Ouagadougou, Burkina Faso; first against an in-country reference standard of culture and/or multiplex PCR; and second against culture and/or a highly sensitive nested PCR technique performed in Oslo, Norway. We included 267 patients with suspected acute bacterial meningitis. Using the in-country reference standard, 50 samples (19%) were positive. Dipstick RDT sensitivity (N = 265) was 70% (95%CI 55–82) and specificity 97% (95%CI 93–99). Using culture and/or nested PCR, 126/259 (49%) samples were positive; dipstick RDT sensitivity (N = 257) was 32% (95%CI 24–41), and specificity was 99% (95%CI 95–100). We found dipstick RDT sensitivity lower than values reported from (i) assessments under ideal laboratory conditions (>90%), and (ii) a prior field evaluation in Niger [89% (95%CI 80–95)]. Specificity, however, was similar to (i), and higher than (ii) [62% (95%CI 48–75)]. At this stage in development, therefore, other tests (e.g., latex) might be preferred for use in peripheral health centres. We highlight the value of field evaluations for new diagnostic tests, and note relatively low sensitivity of a reference standard using multiplex vs. nested PCR. Although the former is the current standard for bacterial meningitis surveillance in the meningitis belt, nested PCR performed in a certified laboratory should be used as an absolute reference when evaluating new diagnostic tests
Transitions/relaxations in polyester adhesive/PET system
The correlations between the transitions and the dielectric relaxation processes of the oriented poly(ethylene terephthalate) (PET) pre-impregnated of the polyester thermoplastic adhesive have been investigated by differential scanning calorimetry (DSC) and dynamic dielectric spectroscopy (DDS). The thermoplastic polyester adhesive and the oriented PET films have been studied as reference samples. This study evidences that the adhesive chain segments is responsible for the physical structure evolution in the PET-oriented film. The transitions and dielectric relaxation modes’ evolutions in the glass transition region appear characteristic of the interphase between adhesive and PET film, which is discussed in terms of molecular mobility. The storage at room temperature of the adhesive tape involves the heterogeneity of the physical structure, characterized by glass transition dissociation. Thus, the correlation between the transitions and the dielectric relaxation processes evidences a segregation of the amorphous phases. Therefore, the physical structure and the properties of the material have been linked to the chemical characteristics
Authenticated key agreement mediated by a proxy re-encryptor for the Internet of Things
International audienceThe Internet of Things (IoT) is composed of a wide range of heterogeneous network devices that communicate with their users and the surrounding devices. The secure communications between these devices are still essential even with little or no previous knowledge about each other and regardless of their resource capabilities. This particular context requires appropriate security mechanisms which should be wellsuited for the heterogeneous nature of IoT devices, without pre-sharing a secret key for each secure connection. In this work, we first propose a novel symmetric cipher proxy re-encryption scheme. Such a primitive allows a user to delegate her decryption rights to another with the help of a semi-trusted proxy, but without giving this latter any information on the transmitted messages and the user's secret keys. We then propose AKAPR, an Authenticated Key Agreement mediated by a Proxy Re-encryptor for IoT. The mechanism permits any two highly resource-constrained devices to establish a secure communication with no prior trust relationship. AKAPR is built upon our proposed proxy re-encryption scheme. It has been proved by ProVerif to provide mutual authentication for participants while preserving the secrecy of the generated session key. In addition, the scheme benefits from the lightness of our proxy re-encryption algorithm as it requires no expensive cryptographic operations such as pairing or modular exponentiatio
A Proof Theoretic Analysis of Intruder Theories
We consider the problem of intruder deduction in security protocol analysis:
that is, deciding whether a given message M can be deduced from a set of
messages Gamma under the theory of blind signatures and arbitrary convergent
equational theories modulo associativity and commutativity (AC) of certain
binary operators. The traditional formulations of intruder deduction are
usually given in natural-deduction-like systems and proving decidability
requires significant effort in showing that the rules are "local" in some
sense. By using the well-known translation between natural deduction and
sequent calculus, we recast the intruder deduction problem as proof search in
sequent calculus, in which locality is immediate. Using standard proof
theoretic methods, such as permutability of rules and cut elimination, we show
that the intruder deduction problem can be reduced, in polynomial time, to the
elementary deduction problem, which amounts to solving certain equations in the
underlying individual equational theories. We show that this result extends to
combinations of disjoint AC-convergent theories whereby the decidability of
intruder deduction under the combined theory reduces to the decidability of
elementary deduction in each constituent theory. To further demonstrate the
utility of the sequent-based approach, we show that, for Dolev-Yao intruders,
our sequent-based techniques can be used to solve the more difficult problem of
solving deducibility constraints, where the sequents to be deduced may contain
gaps (or variables) representing possible messages the intruder may produce.Comment: Extended version of RTA 2009 pape
Relationship Between Biogenic Amines and Free Amino Acid Contents of Winesand Musts from Alentejo (Portugal)
The concentration of biogenic amines and free amino acids was studied in 102
Portuguese wines and 18 musts from Alentejo demarcated (D.O.C.) regions. Most wines
were commercial, except for 38 monovarietals obtained by micro vinification. Musts
from the varieties used to produce the latter wines were also studied. Both biogenic
amines and free amino acids were analyzed by HPLC using fluorescence detection for
their o-phthalaldehyde/fluorenylmethyl chloroformate (OPA/FMOC) derivatives. The
most significant amines (average 10.8 mg/L for histamine+tyramine in red, and 7.4
mg/L for white wines) were found to be present at low levels and, although no important
relationship between each individual biogenic amine could be obtained, the total amine
content depends significantly on the assimilable amino acid content in wine
A Phase II, Randomized Study on an Investigational DTPw-HBV/Hib-MenAC Conjugate Vaccine Administered to Infants in Northern Ghana
BACKGROUND: Combining meningococcal vaccination with routine immunization in infancy may reduce the burden of meningococcal meningitis, especially in the meningitis belt of Africa. We have evaluated the immunogenicity, persistence of immune response, immune memory and safety of an investigational DTPw-HBV/Hib-MenAC conjugate vaccine given to infants in Northern Ghana. METHODS AND FINDINGS: In this phase II, double blind, randomized, controlled study, 280 infants were primed with DTPw-HBV/Hib-MenAC or DTPw-HBV/Hib vaccines at 6, 10 and 14 weeks of age. At 12 months of age, children in each group received a challenge dose of serogroup A+C polysaccharides. Antibody responses were assessed pre, and one month-post dose 3 of the priming schedule and pre and 1 month after administration of the challenge dose. One month post-dose 3, 87.8% and 88.2% of subjects in the study group had bactericidal meningococcal serogroup A (SBA-MenA) and meningococcal serogroup C (SBA-MenC) antibody titres > or = 1:8 respectively. Seroprotection/seropositivity rates to the 5 antigens administered in the routine EPI schedule were non-inferior in children in the study group compared to those in the control group. The percentages of subjects in the study group with persisting SBA-MenA titres > or = 1:8 or SBA-MenC titres > or = 1:8 at the age of 12 months prior to challenge were significantly higher than in control group (47.7% vs 25.7% and 56.4% vs 5.1% respectively). The administration of 10 microg of serogroup A polysaccharide increased the SBA-MenA GMT by 14.0-fold in the DTPW-HBV/HibMenAC-group compared to a 3.8 fold increase in the control-group. Corresponding fold-increases in SBA-MenC titres following challenge with 10 microg of group C polysaccharide were 18.8 and 1.9 respectively. Reactogenicity following primary vaccination or the administration of the challenge dose was similar in both groups, except for swelling (Grade 3) after primary vaccination which was more frequent in children in the vaccine than in the control group (23.7%; 95%CI [19.6-28.1] of doses vs 14.1%; 95% CI [10.9-17.8] of doses). Fifty-nine SAEs (including 8 deaths), none of them related to vaccination, were reported during the entire study. CONCLUSIONS: Three dose primary vaccination with DTPw-HBV/Hib-MenAC was non-inferior to DTPw-HBV/Hib for the 5 common antigens used in the routine EPI schedule and induced bactericidal antibodies against Neisseria meningitidis of serogroups A and C in the majority of infants. Serogroup A and C bactericidal antibody levels had fallen below titres associated with protection in nearly half of the infants by the age of 12 months confirming that a booster dose is required at about that age. An enhanced memory response was shown after polysaccharide challenge. This vaccine could provide protection against 7 important childhood diseases (including meningococcal A and C) and be of particular value in countries of the African meningitis belt. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN35754083
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