63 research outputs found

    The special aspects of Chinese material science terminology

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    Наша статья посвящена анализу терминологии современного китайского материаловедения. В ней рассматриваются входящие в данную терминологию термины и терминологические сочетания, проводится их структурный анализ и на этой основе делаются выводы об особенностях данной терминологии. The article is about analysis of modern Chinese material science terminology. It presents the terms and terminological words combinations which are included in the abovementioned terminology, the structural analysis and our conclusions about the specifics of the terminology

    Investigation of shock waves in explosive blasts using fibre optic pressure sensors

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    The published version of this article may be accessed at the link below. Copyright @ IOP Publishing, 2006.We describe miniature all-optical pressure sensors, fabricated by wafer etching techniques, less than 1 mm(2) in overall cross-section with rise times in the mu s regime and pressure ranges typically 900 kPa (9 bar). Their performance is suitable for experimental studies of the pressure-time history for test models exposed to shocks initiated by an explosive charge. The small size and fast response of the sensors promises higher quality data than has been previously available from conventional electrical sensors, with potential improvements to numerical models of blast effects. Results from blast tests are presented in which up to six sensors were multiplexed, embedded within test models in a range of orientations relative to the shock front.Support from the UK Engineering&Physical Sciences Research Council and Dstl Fort Halstead through the MoD Joint Grants Scheme are acknowledged. WN MacPherson is supported by an EPSRC Advanced Research Fellowship

    First fabrication of full 3D-detectors at SINTEF

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    International audienceA knowledge of the mechanical properties of bacterial biofilms is required to more fully understand the processes of biofilm formation such as initial adhesion or detachment. The main contribution of this article is to demonstrate the use of homogenization techniques to compute mechanical parameters of Pseudomonas aeruginosa PAO1 biofilms. For this purpose, homogenization techniques are used to analyze freeze substitution electron micrographs of the biofilm cross-sections. The concept of a representative volume element and the study about his representativeness allows us to determine the optimal size in order to analyze these biofilm images. Results demonstrate significant heterogeneities with respect to stiffness and these can be explained by varying cell density distribution throughout the bacterial biofilms. These stiffness variations lead to different mechanical properties along the height of the biofilm. Moreover, a numerical shear stress test shows the impact of these heterogeneities on the detachment process. Several modes of detachment are highlighted according to the local strain energy in the different parts of the biofilm. Knowing where, and how, a biofilm may detach will allow better prediction of accumulation and biomass detachment

    Imaging Immune Surveillance of Individual Natural Killer Cells Confined in Microwell Arrays

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    New markers are constantly emerging that identify smaller and smaller subpopulations of immune cells. However, there is a growing awareness that even within very small populations, there is a marked functional heterogeneity and that measurements at the population level only gives an average estimate of the behaviour of that pool of cells. New techniques to analyze single immune cells over time are needed to overcome this limitation. For that purpose, we have designed and evaluated microwell array systems made from two materials, polydimethylsiloxane (PDMS) and silicon, for high-resolution imaging of individual natural killer (NK) cell responses. Both materials were suitable for short-term studies (<4 hours) but only silicon wells allowed long-term studies (several days). Time-lapse imaging of NK cell cytotoxicity in these microwell arrays revealed that roughly 30% of the target cells died much more rapidly than the rest upon NK cell encounter. This unexpected heterogeneity may reflect either separate mechanisms of killing or different killing efficiency by individual NK cells. Furthermore, we show that high-resolution imaging of inhibitory synapse formation, defined by clustering of MHC class I at the interface between NK and target cells, is possible in these microwells. We conclude that live cell imaging of NK-target cell interactions in multi-well microstructures are possible. The technique enables novel types of assays and allow data collection at a level of resolution not previously obtained. Furthermore, due to the large number of wells that can be simultaneously imaged, new statistical information is obtained that will lead to a better understanding of the function and regulation of the immune system at the single cell level

    Laserspektroskopie grosser Molekuele auf der Pico- und Femtosekundenzeitskala

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    Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

    Electron transfer in porphyrin−quinone cyclophanes studied on the pico− and femto−second time scale

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    Electron transfer in porphyrin−quinone cyclophanes is investigated by fluorescence and absorption spectroscopy with pico− and femto−second pulses. In nonpolar solvents, the S1 state of the porphyrin shows a lifetime from 300 ps up to several nanoseconds, depending upon the number of quinones and upon their electron affinity. Comparative measurements in polar solvents demonstrate very fast electron transfer on a time scale between 1 and 10 ps. The results are analyzed with the aid of quantum−chemical calculations which give the energy of the charge transfer states and the relevant coupling strengths. For nonpolar solvents, theory suggests fluctuation−induced charge separation and/or direct radiationless internal conversion from the porphyrin S1 to the ground state. In polar solution, the molecules exist in a tilted configuration with strong electronic coupling and charge transfer states well below the S1 level, resulting in fast electron transfer and subsequent charge recombination within 10−40 p
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