Electronic transport through a parallel--coupled triple quantum dot molecule: Fano resonances and bound states in the continuum

The electronic transport through a triple quantum dot molecule attached in parallel to leads in presence of a magnetic flux is studied. Analytical expressions of the linear conductance and density of states for the molecule in equilibrium at zero temperature are obtained. As a consequence of quantum interference, the conductance exhibits in general a Breit--Wigner and two Fano resonances, the positions and widths of which are controlled by the magnetic field. Every two flux quanta, there is an inversion of roles of the bonding and antibonding states. For particular values of the magnetic flux and dot-lead couplings, one or even both Fano resonances collapse and bound states in the continuum (BIC's) are formed. The line broadenings of the molecular states are examined as a function of the Aharonov--Bohm phase around the condition for the formation of BIC's, finding resonances extremely narrow and robust against variations of the magnetic field.Comment: 15 pages, 7 figure

Actividades educativas para preparar a la familia en la prevención de las alteraciones del ritmo y la fluidez del habla

The stimulation of the language in the preschool childhood has a markedly preventive nuance and it focuses particularly on the training of families, being these the first form of social education, with which the boy and the girl interact from the moment of their birth. It constitute a stable sphere of influence, which acts directly on them, in two important periods in the development of the personality, on childhood and adolescence. The education to the family consists of a pedagogically directed system of influences, aimed at raising the preparation of adult relatives's and stimulating their conscious participation in the formation of descendants in coordination with the school. This education provides knowledge, helps to argue opinions, develops attitudes and convictions, stimulates interests and consolidates motivations, contributing to integrate in parents a humanist and scientist conception of the family and the education of the children. The work will use different educational investigation methods at the theoretical, empirical, and mathematical -statistical levels. The application of educational activities will favor the preparation of the family to prevent the alterations in the rhythm and fluency of speech in the preschool childhood.La estimulación del lenguaje en la infancia preescolar tiene un matiz marcadamente preventivo y se centra de manera particular en la capacitación de las familias, siendo esta la primera forma de educación social, con la que interactúa el niño y la niña desde el momento de su nacimiento. Constituye una esfera de influencia estable que actúa directamente sobre ellos, en dos períodos importantes en el desarrollo de la personalidad, infancia y adolescencia. La educación a la familia consiste en un sistema de influencias pedagógicamente dirigido, encaminado a elevar la preparación de los familiares adultos y estimular su participación consciente en la formación de descendencia en coordinación con la escuela. Esta educación suministra conocimientos, ayuda a argumentar opiniones, desarrolla actitudes y convicciones, estimula intereses y consolida motivaciones, contribuyendo a integrar en los padres una concepción humanista y científica de la familia y la educación de los hijos. En el trabajo se utilizarán diferentes métodos de investigación educativa de los niveles teórico, empírico y matemático-estadístico. La aplicación de actividades educativas en la práctica favorecerá a la preparación de la familia para prevenir las alteraciones del ritmo y la fluidez del habla en la infancia preescola

Ibuprofen-loaded calcium phosphate granules : combination of innovative characterization methods to relate mechanical strength to drug location

This paper studies the impact of the location of a drug substance on the physicochemical and mechanical properties of two types of calcium phosphate granules loaded with seven different contents of ibuprofen, ranging from 1.75% to 46%. These implantable agglomerates were produced by either low or high shear granulation. Unloaded Mi-Pro pellets presented higher sphericity and mechanical properties, but were slightly less porous than Kenwood granules (57.7% vs 61.2%). Nevertheless, the whole expected quantity of ibuprofen could be integrated into both types of granules. A combination of surface analysis, using near-infrared (NIR) spectroscopy coupling chemical imaging, and pellet porosity, by mercury intrusion measurements, allowed ibuprofen to be located. It was shown that, from 0% to 22% drug content, ibuprofen deposited simultaneously on the granule surface, as evidenced by the increase in surface NIR signal, and inside the pores, as highlighted by the decrease in pore volume. From 22%, porosity was almost filled, and additional drug substance coated the granule surfaces, leading to a large increase in the surface NIR signal. This coating was more regular for Mi-Pro pellets owing to their higher sphericity and greater surface deposition of drug substance. Unit crush tests using a microindenter revealed that ibuprofen loading enhanced the mechanical strength of granules, especially above 22% drug content, which was favorable to further application of the granules as a bone defect filler

Transport through a quantum wire with a side quantum-dot array

A noninteracting quantum-dot array side-coupled to a quantum wire is studied. Transport through the quantum wire is investigated by using a noninteracting Anderson tunneling Hamiltonian. The conductance at zero temperature develops an oscillating band with resonances and antiresonances due to constructive and destructive interference in the ballistic channel, respectively. Moreover, we have found an odd-even parity in the system, whose conductance vanishes for an odd number of quantum dots while becomes $2e^2/h$ for an even number. We established an explicit relation between this odd-even parity, and the positions of the resonances and antiresonances of the conductivity with the spectrum of the isolated QD arrayComment: 5 pages, 4 figures, submitted to PR

Conductance and persistent current of a quantum ring coupled to a quantum wire under external fields

The electronic transport of a noninteracting quantum ring side-coupled to a quantum wire is studied via a single-band tunneling tight-binding Hamiltonian. We found that the system develops an oscillating band with antiresonances and resonances arising from the hybridization of the quasibound levels of the ring and the coupling to the quantum wire. The positions of the antiresonances correspond exactly to the electronic spectrum of the isolated ring. Moreover, for a uniform quantum ring the conductance and the persistent current density were found to exhibit a particular odd-even parity related with the ring-order. The effects of an in-plane electric field was also studied. This field shifts the electronic spectrum and damps the amplitude of the persistent current density. These features may be used to control externally the energy spectra and the amplitude of the persistent current.Comment: Revised version, 7 pages and 9 figures. To appear in Phys. Rev.

Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study.

BACKGROUND AND AIMS: ENHANCE was a phase 3 study that evaluated efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-δ (PPAR) agonist, versus placebo in patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid (UDCA). APPROACH AND RESULTS: Patients were randomized 1:1:1 to oral seladelpar 5 mg (n=89), 10 mg (n=89), placebo (n=87) daily (with UDCA, as appropriate). Primary end point was a composite biochemical response [alkaline phosphatase (ALP) < 1.67×upper limit of normal (ULN), ≥15% ALP decrease from baseline, and total bilirubin ≤ ULN] at month 12. Key secondary end points were ALP normalization at month 12 and change in pruritus numerical rating scale (NRS) at month 6 in patients with baseline score ≥4. Aminotransferases were assessed. ENHANCE was terminated early following an erroneous safety signal in a concurrent, NASH trial. While blinded, primary and secondary efficacy end points were amended to month 3. Significantly more patients receiving seladelpar met the primary end point (seladelpar 5 mg: 57.1%, 10 mg: 78.2%) versus placebo (12.5%) ( p < 0.0001). ALP normalization occurred in 5.4% ( p =0.08) and 27.3% ( p < 0.0001) of patients receiving 5 and 10 mg seladelpar, respectively, versus 0% receiving placebo. Seladelpar 10 mg significantly reduced mean pruritus NRS versus placebo [10 mg: -3.14 ( p =0.02); placebo: -1.55]. Alanine aminotransferase decreased significantly with seladelpar versus placebo [5 mg: 23.4% ( p =0.0008); 10 mg: 16.7% ( p =0.03); placebo: 4%]. There were no serious treatment-related adverse events. CONCLUSIONS: Patients with primary biliary cholangitis (PBC) with inadequate response or intolerance to UDCA who were treated with seladelpar 10 mg had significant improvements in liver biochemistry and pruritus. Seladelpar appeared safe and well tolerated

Оценка воздействия производственной деятельности теплогенерирующего предприятия на атмосферный воздух

Объектом исследования теоретической части работы является исследование котельных установок и газоочистных установок для очистки промышленных газов. Объектом исследования практической части работы является анализ воздействия выбросов загрязняющих веществ от объектов ООО «Бакчартепло».The object of study the theoretical part of the work is to study the boiler plants and gas-cleaning unit for cleaning industrial gases. The object of study of the practical work is to analyze the impact of emissions from the facilities of OOO "Bakcharteplo"