The study of microcirculation in the subcutaneous tissue by the method of tissue clearance Na¹³¹I in diabetic patients with medication acting on the condition of blood haemoreological properties

The study is focused on the possibility of early diagnosis of diabetic microangiopathy. Authors used examination of microcirculation by the method of tissue clearance of Na¹³¹I. Some drugs can influence the status of vessels and haemoreological attributes of the blood. These drugs include glycosaminoglycane sulodexide, indobuphen, serotonine receptors antagonists, naphtidrophuryl, pentoxyphyllin, alprostadil. The aim of the study was to prove their influence on blood perfusion in capillary course.Целью исследования является возможность ранней диагностики диабетической микроангиопатии. Авторы использовали исследование микроциркуляции методом клиренса ткани Na¹³¹I. Некоторые лекарства могут влиять на состояние сосудов и гемореологические свойства крови. Эти лекарственные средства включают гликозаминогликановый сулодексид, индобуфен, антагонисты серотониновых рецепторов, нафтидрофурил, пентоксифиллин, алпростадил. Целью исследования было доказать их влияние на перфузию крови в капиллярном русле.Метою дослідження є можливість ранньої діагностики діабетичної мікроангіопатії. Автори використовували дослідження мікроциркуляції методом кліренсу Na¹³¹I. Деякі ліки можуть впливати на стан судин і гемореологічні властивості крові. Ці лікарські засоби включають глікозаміноглікановий сулодексид, індобуфен, антагоністи серотонінових рецепторів, нафтідрофуріл, пентоксифілін, алпростаділ. Метою дослідження було довести їх вплив на перфузію крові в капілярному руслі

Urban vs. Rural socioeconomic differences in the nutritional quality of household packaged food purchases by store type

The U.S. food system is rapidly changing, including the growth of mass merchandisers and dollar stores, which may impact the quality of packaged food purchases (PFPs). Furthermore, diet-related disparities exist by socioeconomic status (SES) and rural residence. We use data from the 2010–2018 Nielsen Homescan Panel to describe the nutritional profiles of PFPs by store type and to assess whether these vary by household urbanicity and SES. Store types include grocery stores, mass merchandisers, club stores, online shopping, dollar stores, and convenience/drug stores. Food and beverage groups contributing the most calories at each store type are estimated using survey-weighted means, while the associations of urbanicity and SES with nutritional quality are estimated using multivariate regression. We find that households that are customers at particular store types purchase the same quality of food regardless of urbanicity or SES. However, we find differences in the quality of foods between store types and that the quantity of calories purchased at each store type varies according to household urbanicity and SES. Rural shoppers tend to shop more at mass merchandisers and dollar stores with less healthful PFPs. We discuss implications for the types of store interventions most relevant for improving the quality of PFPs

How do child and adolescent mental health problems influence public sector costs? Interindividual variations in a nationally representative British sample.

Author's manuscript version. The final published version of the article is available from the publisher as an open access article via: DOI: 10.1111/jcpp.12327BACKGROUND: Policy and practice guidelines emphasize that responses to children and young people with poor mental health should be tailored to needs, but little is known about the impact on costs. We investigated variations in service-related public sector costs for a nationally representative sample of children in Britain, focusing on the impact of mental health problems. METHODS: Analysis of service uses data and associated costs for 2461 children aged 5-15 from the British Child and Adolescent Mental Health Surveys. Multivariate statistical analyses, including two-part models, examined factors potentially associated with interindividual differences in service use related to emotional or behavioural problems and cost. We categorized service use into primary care, specialist mental health services, frontline education, special education and social care. RESULTS: Marked interindividual variations in utilization and costs were observed. Impairment, reading attainment, child age, gender and ethnicity, maternal age, parental anxiety and depression, social class, family size and functioning were significantly associated with utilization and/or costs. CONCLUSIONS: Unexplained variation in costs could indicate poor targeting, inequality and inefficiency in the way that mental health, education and social care systems respond to emotional and behavioural problems.Department of Health (England)Wellcome Trus

Extracellular Matrix Disparities in an \u3ci\u3eNkx2-5\u3c/i\u3e Mutant Mouse Model of Congenital Heart Disease

Congenital heart disease (CHD) affects almost one percent of all live births. Despite diagnostic and surgical reparative advances, the causes and mechanisms of CHD are still primarily unknown. The extracellular matrix plays a large role in cell communication, function, and differentiation, and therefore likely plays a role in disease development and pathophysiology. Cell adhesion and gap junction proteins, such as integrins and connexins, are also essential to cellular communication and behavior, and could interact directly (integrins) or indirectly (connexins) with the extracellular matrix. In this work, we explore disparities in the expression and spatial patterning of extracellular matrix, adhesion, and gap junction proteins between wild type and Nkx2-5+/R52G mutant mice. Decellularization and proteomic analysis, Western blotting, histology, immunostaining, and mechanical assessment of embryonic and neonatal wild type and Nkx2-5 mutant mouse hearts were performed. An increased abundance of collagen IV, fibronectin, and integrin β-1 was found in Nkx2-5 mutant neonatal mouse hearts, as well as increased expression of connexin 43 in embryonic mutant hearts. Furthermore, a ventricular noncompaction phenotype was observed in both embryonic and neonatal mutant hearts, as well as spatial disorganization of ECM proteins collagen IV and laminin in mutant hearts. Characterizing such properties in a mutant mouse model provides valuable information that can be applied to better understanding the mechanisms of congenital heart disease

Service user and caregiver involvement in mental health system strengthening in low- and middle-income countries: a cross-country qualitative study

The aims of this paper are to: (i) explore the experiences of involvement of mental health service users, their caregivers, mental health centre heads and policy makers in mental health system strengthening in three low- and middle-income countries (LMICs) (Ethiopia, Nepal and Nigeria); (ii) analyse the potential benefits and barriers of such involvement; and (iii) identify strategies required to achieve greater service user and caregiver participation. A cross-country qualitative study was conducted, interviewing 83 stakeholders of mental health services. Our analysis showed that service user and caregiver involvement in the health system strengthening process was an alien concept for most participants. They reported very limited access to direct participation. Stigma and poverty were described as the main barriers for involvement. Several strategies were identified by participants to overcome existing hurdles to facilitate service user and caregiver involvement in the mental health system strengthening process, such as support to access treatment, mental health promotion and empowerment of service users. This study suggests that capacity building for service users, and strengthening of user groups would equip them to contribute meaningfully to policy development from informed perspectives. Involvement of service users and their caregivers in mental health decision-making is still in its infancy in LMICs. Effective strategies are required to overcome existing barriers, for example making funding more widely available for Ph.D. studies in participatory research with service users and caregivers to develop, implement and evaluate approaches to involvement that are locally and culturally acceptable in LMICs

School-based intervention study examining approaches for well-being and mental health literacy of pupils in Year 9 in England: study protocol for a multischool, parallel group cluster randomised controlled trial (AWARE) (vol 12, artne029044corr1, 20022)

The authors would like to notify that the co-authors Sara Evans-Lacko, Bettina Moltrecht, Kirsty Nisbet, Emma Thornton, Aurelie Lange, Paul Stallard, Abigail Thompson were missed including in the authorship list of the paper. The supplementary file has been also updated

Coping with stigma and discrimination: evidence from mental health service users in England

Mental health stigma and discrimination are significant problems. Common coping orientations include: concealing mental health problems, challenging others and educating others. We describe the use of common stigma coping orientations and explain variations within a sample of English mental health service users. Cross-sectional survey data were collected as part of the Viewpoint survey of mental health service users’ experiences of discrimination (n = 3005). Linear regression analyses were carried out to identify factors associated with the three stigma coping orientations. The most common coping orientation was to conceal mental health problems (73%), which was strongly associated with anticipated discrimination. Only 51% ever challenged others because of discriminating behaviour, this being related to experienced discrimination, but also to higher confidence to tackle stigma. Although stigma coping orientations vary by context, individuals often choose to conceal problems, which is associated with greater anticipated and experienced discrimination and less confidence to challenge stigma. The direction of this association requires further investigation

About the Problem of Differentiation Between the Oaks Quercus pubescens Willd. and Quercus virgiliana. (Ten.) Ten.

U radu su prikazane razlike između srodnih maljavodlakavih hrastova Quercus pubescens i Q. virgiliana. Isto tako prikazana je njihova približna rasprostranjenost u Hrvatskoj, te mogućnost njihova razlikovanja na terenu. Istaknute su i poteškoće u uspješnom određivanju i prepoznavanju navedenih hrastova.In the work the morphological differences between the related downy hairy oaks Quercus pubescens and Q. virgiliana are analyzed. They occupy large areas especially in the Adriatic littoral of the Republic of Croatia, but they develop sporadically in its hinterland, too. The said oaks can be differentiated from each other by the morphology of their leaf, cupule and bark, by the arrangement of flowers on a short fruit shoot as well as by the appearance of their cupule. Q. pubescens has a leaf with 4–6 pairs of lateral lobes, and the petiole is 1–2 cm, maximum 3 cm, long. Its bark at the trunk base is shallowly longitudinally furrowed. All female flowers of the short, fruit shoot are sitting, placed terminally. All ripe acorns are sitting, placed terminally. The cupule covered with small, triangular scales arranged like tiles on a roof is smooth in appearance. Q. virgiliana has a leaf with 3–4 (-5) pairs of lateral lobes, and the petiole is more than 3 cm long. Its bark at the trunk base is deeply furrowed, on the cross cut like a cogwheel. The female flowers are arranged on a more or less long rachis, not longer than 10 cm, in the form of an ear, and the ears can be arranged both terminally and laterally in leaf axils. In the ear there are often clusters of several flowers. One or several ripe acorns are on a more or less long stalk, usually 1–2 cm long. At the top or sidewise on the cupule the remnant of the rachis can often be noticed in the form of a curved, dry extension. The cupule scales are verrucously swollen or protuberated, making the entire cupule verrucously wrinkled. In case of any deviation from the above parameters, as a rule the hybrids are involved

Key lessons learned from the INDIGO global network on mental health related stigma and discrimination

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