Senescent cells: an emerging target for diseases of ageing

Contains fulltext : 182660.pdf (publisher's version ) (Closed access)Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies

Lung Tumors

In children, primary lung tumors are rare, but metastases are much more common. Lung masses in children are ten-times more likely to be a developmental or reactive lesion than a tumor. The ratio of primary tumors to metastatic tumors to non-neoplastic lesions is estimated to be 1:5:60.1 . On the basis of the rarity of primary lung tumors in children, the diagnosis remains a challenge. Several cases are asymptomatic or present with non-specific symptoms, and they are discovered incidentally