60 research outputs found
Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels
Chronic pain is a global problem affecting up to 20% of the world’s population and has a significant economic, social and personal cost to society. Sensory neurons of the dorsal root ganglia (DRG) detect noxious stimuli and transmit this sensory information to regions of the central nervous system (CNS) where activity is perceived as pain. DRG neurons express multiple voltage-gated sodium channels that underlie their excitability. Research over the last 20 years has provided valuable insights into the critical roles that two channels, NaV1.7 and NaV1.9, play in pain signalling in man. Gain of function mutations in NaV1.7 cause painful conditions while loss of function mutations cause complete insensitivity to pain. Only gain of function mutations have been reported for NaV1.9. However, while most NaV1.9 mutations lead to painful conditions, a few are reported to cause insensitivity to pain. The critical roles these channels play in pain along with their low expression in the CNS and heart muscle suggest they are valid targets for novel analgesic drugs
Study and Development of Polymer Spontaneous Destabilization by Capillary NIL
International audienc
Study and Development of Polymer Destabilization by Capillary NIL
International audienc
Study and Development of Polymer Destabilization by Capillary NIL: Effect of Charges
International audienc
Plasma etching of high aspect ratio GaN and AlN nanopillar arrays for next generation of ultraviolet lightemitting diodes fabrication
International audienc
Superhydrophobic Polymeric Films with Hierarchical Structures Produced by Nanoimprint (NIL) and Plasma Roughening
International audienc
PAR-XPS investigations of ultrathin SiO2 layers grown by PEALD on SiGe and Ge
International audienc
Plasma etching of high aspect ratio GaN and AlN nanopillars for the next generation of ultraviolet light-emitting diodes
International audienc
Etude des phénomènes de physisorption d’espèces chimiques sur des plaques de Si 300mm lors des transferts en mini-environnement contrôlés entre équipements en microélectronique
International audienc
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