SNO KARST: a French network of observatories for the multidisciplinary study of critical zone processes in karst watersheds and aquifers

Karst aquifers and watersheds represent a major source of drinking water around the world. They are also known as complex and often highly vulnerable hydrosystems due to strong surface groundwater interactions. Improving the understanding of karst functioning is thus a major issue for an efficient management of karst groundwater resources. A comprehensive understanding of the various processes can be achieved only by studying karst systems over a wide range of spatio-temporal scales under different geological, geomorphological, climatic and soil cover settings. The objective of the French Karst National Observatory Service (SNO Karst) is to supply the international scientific community with appropriate data and tools, with the ambition of i) facilitating the collection of long-term observations of hydro-geo-chemical variables in karst, and ii) promoting knowledge-sharing and developing cross-disciplinary research on karst. The present paper provides an overview of the monitoring sites and of collective achievements such as the KarstMod modular modelling platform and the PaPRIKa toolbox. It also presents the research questions addressed within the framework of SNO Karst, along with major research results regarding i) the hydrological response of karst to climate and anthropogenic changes, ii) the influence of karst on geochemical balance of watersheds in the critical zone, and iii) the relationships between the structure and hydrological functioning of karst aquifers and watersheds

A TSC22-like motif defines a novel antiapoptotic protein family

The apoptotic programme is evolutionarily conserved between yeast and metazoan organisms. We have previously identified a number of mammalian cDNAs capable of suppressing the deleterious effects of Bax expression in yeast. We herein report that one such suppressor, named Tsc22(86), represents the C-terminal 86 amino acids of the previously characterized leucine zipper (LZ) motif-containing transcriptional regulator Tsc22. Employing a genome-wide two-hybrid screen, functional genomics, and deletion mutagenesis approaches, we conclude that Tsc22(86)-mediated antiapoptosis is independent of the LZ motif and is likely independent of effects on gene transcription. Rather, a 16-residue sequence within the conserved 56-residue TSC22 domain is necessary for antiapoptosis. The presence of a similar sequence was used to predict an antiapoptotic role for two yeast proteins, Sno1p and Fyv10p. Overexpression and knock-out experiments were used to validate this prediction. These findings demonstrate the potential of studying heterologous proteins in yeast to uncover novel biological insights into the regulation of apoptosis

welcher die Fortsezung dessen zweiter Reise nach Welschland enthält

Die Titelseite ist einseitig bedrucktAutopsie nach Ex. der SBBVorlageform der Veröffentlichungsangabe: "Frankfurt und Leipzig, bey Adam Jonathan Felßecker seel. Erben 1761." - Frankfurt, Main und Leipzig sind Messplätze. - Verlagsort in CERL bzw. Paisey ermittel

welcher die Fortsezung seiner zweiten Reise nach Welschland enthält

Die Titelseite ist einseitig bedrucktAutopsie nach Ex. der SBBVorlageform der Veröffentlichungsangabe: "Frankfurt und Leipzig, bey Adam Jonathan Felßeckers seel. Erben 1760." - Frankfurt, Main und Leipzig sind Messplätze. - Verlagsort in CERL bzw. Paisey ermittel

welcher die Reise nach Spanien, und im Anhang die berühmte Creuzbulle Urbans VIII. enthält

Die Titelseite ist einseitig bedrucktAutopsie nach Ex. der SBBVorlageform der Veröffentlichungsangabe: "Frankfurt und Leipzig, bey Adam Jonathan Felßeckers seel. Erben 1758." - Frankfurt, Main und Leipzig sind Messplätze. - Verlagsort in CERL bzw. Paisey ermittel

Voyage du chevalier Des Marchais en Guinée, isles voisines et a Cayenne, fait en 1725, 1726 & 1727 : contenant une description très exacte & très étenduë de ces païs, & du commerce qui s'y fait ...

par le R. Père Labat ...Frontispiz in T. 1; Titel in Rot- und Schwarzdruck; TitelvignettePaginierung springt in T. 4 von S. 288 auf S. 38