Borderline personality in patients with poly-diagnoses treated for a Bipolar Disorder

Some patients with dysphoria, explosive behaviour, or suicidal ideation, may receive a diagnosis of, and treatment for Bipolar Disorder (BD) and, not infrequently. The coexistence of these two diagnoses has been explained in different ways. Some authors include the BPD in the bipolar spectrum; others are sceptical about the existence of real comorbidity, suggesting a misdiagnosis. This study aimed to assess the personality of this group of poly-diagnosed patients (PolyD) and hypothesised they had a pathological borderline organisation. Via the administration of the Schedler Westen Assessment Procedure (SWAP-200), we compared PolyD patients with those suffering from BPD or BD only. We performed two different MANCOVAs to test PolyD, BPD and BD patients' differences in PD-factors, Q-traits and age. The sample comprised 45 patients (Mean age=43.3, SD=15.7; Females 57.7%, N=26). BD patients (N=15) did not present any personality disorder, they had a higher functioning and Obsessive Q-traits, and a lower Histrionic PD-factor than both PolyD (N=20) and BPD (N=10) patients. Compared to PolyD patients, BD had inferior PD-Borderline, PD-Antisocial factor and Dependent-Masochistic Q-traits, but there were no other differences with BPD patients. PolyD did not differ from BPD patients in any of the PD-factors and Q-traits. Our results suggest that PolyD patients are different from BD patients and propose to consider the pathological borderline personality as a central core of their disease

Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: current trends and future perspectives

Alzheimer’s disease (AD), the most common form of dementia, is a progressive and multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due to the increase in life expectancy of world population, including developing countries, AD, whose incidence rises dramatically with age, is at the forefront among neurodegenerative diseases. Moreover, a definitive cure is not yet within reach, imposing substantial medical and public health burdens at every latitude. Therefore, the effort to devise novel and effective therapeutic strategies is still of paramount importance. Genetic, functional, structural and biochemical studies all indicate that new and efficacious drug delivery strategies interfere at different levels with various cellular and molecular targets. Over the last few decades, therapeutic development of nanomedicine at preclinical stage has shown to progress at a fast pace, thus paving the way for its potential impact on human health in improving prevention, diagnosis, and treatment of age-related neurodegenerative disorders, including AD. Clinical translation of nano-based therapeutics, despite current limitations, may present important advantages and innovation to be exploited in the neuroscience field as well. In this state-of-the-art review article, we present the most promising applications of polymeric nanoparticle-mediated drug delivery for bypassing the blood-brain barrier of AD preclinical models and boost pharmacological safety and efficacy. In particular, novel strategic chemical functionalization of polymeric nanocarriers that could be successfully employed for treating AD are thoroughly described. Emphasis is also placed on nanotheranostics as both potential therapeutic and diagnostic tool for targeted treatments. Our review highlights the emerging role of nanomedicine in the management of AD, providing the readers with an overview of the nanostrategies currently available to develop future therapeutic applications against this chronic neurodegenerative disease

Modeling storm water control operated by green roofs at the urban catchment scale

The urban catchment of Colle Ometti, in the town of Genoa, Italy, where storm water runoff is monitored for both quantity and quality, was selected as a test site for the hydrologic modelling of greening scenarios. Although no green roof installations are now present in the area, this study modelled \u2013 using extensive green roof details \u2013 the hydrologic effects of three hypothetical roof greenin scenarios at the catchment scale (conversion of 10%, 20%, and 100% impervious to green roofs). The modelling of green roof performances was undertaken using the EPA SWMM and was calibrated and validated on a small size green roof system completed in September 2007 in the laboratory of the Department of Civil, Environmental and Architectural Engineering (DICAT \u2013 University of Genoa). Precipitation scenarios were developed based on eighteen years of high resolution (one minute) rain gauge data in Genoa (1990-2007).Hydrologic modelling demonstrated that widespread green roof implementation can significantly reduce peak runoff rates and the lag time (7min and 15 min) runoff volume (detention effect) while after introducing the drying process operated by evapo-traspiration during the inter-event period the runoff volume reduction at the event scale (retention effect) can also be appreciated

INCIDENCE OF PSYCHOTIC DISORDERS IN PALERMO: PRELIMINARY DATA

Background: The incidence of psychotic disorders varies in different geographical areas (McGrath 2004). Recent data suggest that the incidence is higher in males, migrant minorities and in urban areas. There aren\u2019t many available epidemiological data on the incidence of psychotic disorders in Italy. This is the first incidence study on psychotic disorders carried out in Palermo, the capital of Sicily. Methods: we screened all patients presenting with their first episode of psychosis to the mental health services of our catchment area (5 inpatient, 5 outpatient units and 3 private psychiatric hospitals) over a period of three years (2008-2011). The diagnosis of psychosis was defined using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN Wing, J. K., et al., 1990).The main socio-demographic data were collected using the MRC Social Data Schedule. When subjects were not available (did not consent) for interview, information was collected from clinical notes. The population at risk referred to the people aged from 18-65 who were resident in the same catchment area (Palermo Municipality) in the period considered, according to the data of the Statistic Office of Palermo Municipality). Results: we identified 216 patients affected by a first episode of psychosis (FEP): 135 M (62.5%) and 81 F (37.5%), mean age 31.42 years (SD: 11.44). 77.1% of FEP had a diagnosis of non affective psychosis, 12.8% of affective psychosis and 10.1% received a diagnosis of other psychosis. 204 subjects were Caucasian, 12 non Caucasian belonging to various ethnicities and they were all first generation migrants (4 Indian, 3 African, 2 Bangladeshi, and 3 Mixed). Population at risk is 425.194 people. The mean age of onset was lower in men than women M: 29.98 years (SD: 10.41) vs. F: 34.28 (SD:12.64) (p=0.013)The incidence of psychotic disorders in our catchment area is 16,9 per 100.000 person years. It was higher in men 21,9 per 100.000 than women 12,2 per 100.000. Discussion: Our study is the first epidemiological study in Sicily investigating the incidence of psychotic disorders. In our population men have a higher incidence of psychotic disorders than women and an earlier age of onset

The Faber-Jackson relation for early-type galaxies: Dependence on the magnitude range

We take a sample of early-type galaxies from the Sloan Digital Sky Survey (SDSS-DR7, $\sim$ 90 000 galaxies) spanning a range of approximately 7 $mag$ in both $g$ and $r$ filters and analyse the behaviour of the Faber-Jackson relation parameters as functions of the magnitude range. We calculate the parameters in two ways: i) We consider the faintest (brightest) galaxies in each sample and we progressively increase the width of the magnitude interval by inclusion of the brighter (fainter) galaxies (increasing-magnitude-intervals), and ii) we consider narrow-magnitude intervals of the same width ($\Delta M = 1.0$ $mag$) over the whole magnitude range available (narrow-magnitude-intervals). Our main results are that: i) in both increasing and narrow-magnitude-intervals the Faber-Jackson relation parameters change systematically, ii) non-parametric tests show that the fluctuations in the values of the slope of the Faber-Jackson relation are not products of chance variations. We conclude that the values of the Faber-Jackson relation parameters depend on the width of the magnitude range and the luminosity of galaxies within the magnitude range. This dependence is caused, to a great extent by the selection effects and because the geometrical shape of the distribution of galaxies on the $M - \log (\sigma_{0})$ plane depends on luminosity. We therefore emphasize that if the luminosity of galaxies or the width of the magnitude range or both are not taken into consideration when comparing the structural relations of galaxy samples for different wavelengths, environments, redshifts and luminosities, any differences found may be misinterpreted.Comment: 15 pages, 5 figures. A&A. Accepte

Modular implant design affects metal ion release following metal-on-metal hip arthroplasty: a retrospective study on 75 cases

Metal-on-Metal (MoM) total hip arthroplasty (THA) has been associated to wear and metal-ions release, controversially related to a variety of clinical complications. Little is known about the relevant design-dependent parameters involved in this process. The present study investigated the correlation between metal ion release in blood and revision rate as a function of: (i) specific MoM implant modular design parameters, (i.e. acetabular cup and femoral head diameters, taper adapter material and size, femoral neck material and modularity and stem size); (ii) MoM bilaterality. Co and Cr ions concentration levels in blood of 75 patients were retrospectively-evaluated with a mean follow-up of 4.8 years (range: 1.8-6.3). Patients were divided in a unilateral and a bilateral group. Statistical analysis was performed to find any significant difference related to acetabular cup diameter, femoral head diameter, taper adapter material/size, neck material/size and stem size. The bilateral MoM group had 4-times higher metal ion levels in blood than the unilateral one (p=0.017 only Cr), related to a higher revision rate (30% vs 20%): differences were 10-times higher particularly with a 48 mm femoral head diameter (p=0.012) and a Ti-alloy neck (p=0.041). Within the monolateral group using a shorter taper adapter and a shorter neutrally-oriented neck demonstrated higher ion levels (p=0.038 only Cr and p=0.008 only Co, respectively). The aforementioned design-features and MoM bilaterality are important risk-factors for metal-ion release in modular MoM THA

The 0.1-100 keV Spectrum of LMC X-4 in the High State: Evidence for a High Energy Cyclotron Absorption Line

We report on the spectral analysis of the X-ray pulsar LMC X-4 in its high state out of eclipse observed by BeppoSAX. During this observation no coherent pulsations are detected. The primary continuum is well described by a power law with a high energy cutoff (E_cutoff ~ E_fold ~ 18 keV). The addition of a cyclotron absorption line at ~100 keV improves the fit significantly. The inferred magnetic moment is 1.1 10^{31} Gauss cm^3, in agreement with the value estimated assuming that the neutron star is at the spin equilibrium, as it has been proposed for this source. The remaining excess at low energies can be fitted by a Comptonization of soft photons by moderately hot electrons (kT ~0.9 keV), with an optical depth \tau ~ 16. The seed photons for this Comptonization are consistent with black body emission from the accretion disk at the magnetospheric radius. Another possibility is to fit the soft excess with black body and thermal bremsstrahlung. In this case the black body would originate from cold plasma at the magnetosphere while the bremsstrahlung component may be produced by the strong stellar wind from the companion star, ionized by the X-ray emission from the pulsar.Comment: 13 pages and 6 figures. Apj, in pres