5 research outputs found
Comparison between indirect enzyme-linked immunosorbent assays for Anaplasma marginale antibodies with recombinant major surface protein 5 and initial body antigens
- Author
- Ajayi SA
- Andrade GM
- Barros SL
- Barry DN
- Bracho MA
- Carlos AN Ramos
- Claudio R Madruga
- Cleber O Soares
- Correa WM
- Dumler JS
- FlĂĄbio R AraĂșjo
- Gisele Bacanelli
- Kano FS
- Knowles D
- Lenita R Santos
- Madruga CR
- Mahoney DF
- Maria AO Almeida
- McGuire TC
- Ndung'u LW
- Neophytou PI
- Oberle SM
- Oliveira JB
- Palmer GH
- Palmer GH
- Palmer GH
- Raul H Kessler
- Reyna-Bello A
- Riding G
- Roberto AA Torres JĂșnior
- StĂȘnio P Fragoso
- Torioni de Echaide S
- Tuszynski GP
- VirgĂnia MG Silva
- Visser ES
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Characterization of Anaplasma phagocytophilum and A. ovis infection in a naturally infected sheep flock with poor health condition
- Author
- A Torina
- A Torina
- A Torina
- A Torina
- Alessandra Torina
- Angelina Alongi
- Christian Gortazar
- DP Knowles
- EJ Splitter
- G Manilla
- GA Scoles
- J Fuente de la
- J Fuente de la
- J Fuente de la
- JoaquĂn Vicente
- José de la Fuente
- JS Dumler
- Katherine M. Kocan
- KM Kocan
- KT Friedhoff
- LW Ndung'u
- Michele Fiasconaro
- Miriam Russo
- Ruth C. Galindo
- S Caracappa
- Salvatore Scimeca
- Santo Caracappa
- T Tibbitts
- Vincenzo Aronica
- Vincenzo Di Marco
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Identification of Anaplasma ovis appendage-associated protein (AAAP) for development of an indirect ELISA and its application
- Author
- A Torina
- A Torina
- AS Olmeda
- B Al-Adhami
- C Silaghi
- DM French
- DN Perkins
- ES Visser
- G Eid
- G Uilenberg
- GA Scoles
- GH Palmer
- GH Palmer
- Guangyuan Liu
- H Ait Lbacha
- H Yin
- H Yin
- Hong Yin
- J de la Fuente
- J Fuente de la
- J Fuente de la
- Jianxun Luo
- Jifei Yang
- JL Zaugg
- JP Krier
- Kelly A. Brayton
- KL Kuttler
- KM Kocan
- KT Friedhoff
- LW Ndung'u
- M Ben Said
- M Ma
- MH Zweig
- MJ Dark
- P Aubry
- Q Chi
- Qingli Niu
- RW Stich
- S Hornok
- S Renneker
- S Shompole
- T Tibbitts
- TC McGuire
- UM Dreher
- W Lu
- Y Zhang
- Z Liu
- Z Zhou
- Zhenguo Wang
- Zhijie Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Trypanosoma brucei Invasion and T-Cell Infiltration of the Brain Parenchyma in Experimental Sleeping Sickness: Timing and Correlation with Functional Changes
- Author
- A Buguet
- A Buguet
- A Buguet
- A Casas-SĂĄnchez
- A Darsaud
- A Darsaud
- AK Njamnshi
- Barbara Bradley
- C Chevrier
- C Mulenga
- C Untucht
- Claudia Laperchia
- D Gerashchenko
- D Kaba
- D Squarre
- D Sudarshi
- EM FĂšvre
- G Grassi-Zucconi
- G Wei
- Gigliola Grassi-Zucconi
- H Wolburg
- J Blum
- J Rodgers
- J Rodgers
- JA Coles
- JA Ruiz-Postigo
- Jean Rodgers
- Joseph Mathu Ndung'u
- K Kristensson
- K Obukuro
- L Berrang-Ford
- L Chen
- L MacLean
- LM MacLean
- LW Swanson
- M Palomba
- M Schultzberg
- Maria Palomba
- Marina Bentivoglio
- MJ Sateia
- N Quan
- N Ueno
- P KivisÀkk
- Paul F. Seke Etet
- Paul Montague
- Peter G. E. Kennedy
- PF Seke Etet
- PG Kennedy
- PG Kennedy
- PK Olszewski
- PP Simarro
- PP Simarro
- R Brun
- RE Brown
- RM Chemelli
- RM Ransohoff
- RS Liblau
- S Mogk
- S Mogk
- S Mogk
- S Morita
- S Tabuchi
- SC Welburn
- TE Scammell
- U Frevert
- W Masocha
- W Masocha
- WM Pardridge
- Y Dauvilliers
- YZ Xu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
- Azbel L
- Azizuyo B
- Babiker A
- Babikhina K
- Back D
- Badjé A
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baeten J
- Baggaley R
- Baghazal A
- Bagley Z
- Bah-sow O
- Baijnath P
- Bailey R
- Bailey R
- Bajos N
- Bajracharya A
- Bajunirwe F
- Bakowska E
- Bakwalufu J
- Balestre E
- Balkan S
- Balzer L
- Bamba A
- Banda G
- Banda K
- Bandason T
- Bangsberg
- Baral S
- Baral S
- Baral S
- Baral S
- Baral S
- Barasa M
- Barber M
- Barbour R
- Barde A
- Bardeguez A
- Barihuta T
- Barker C
- Barnabas R
- Barnes P
- Barnighausen T
- Baron D
- Barone M
- Barr D
- Barrenas C
- Barrington C
- Barron P
- Baruwa E
- Basar M
- Bassett I
- Bassett J
- Bassett J
- Bastos F
- Batrouney C
- Bauer G
- Baum M
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bautista-Arredondo S
- Bavinton B
- Bavinton B
- Baxter C
- Baya J
- Bazin B
- Bañón S
- Beauchamp G
- Beauchamp G
- Beck G
- Beckham S
- Bedi K
- Bekker L-G
- Beletsky L
- Belkind U
- Bell J
- Belloso W
- Belonosova E
- Belzer M
- Benedetti M
- Benfield T
- Bennett K
- Bennett K
- Bennett K
- Benson S
- Bere A
- Berkhout B
- Bermudez LG
- Bernard E
- Bernardo V
- Bernaud C
- Bertrand S
- Bhagani
- Bhardwaj K
- Bhardwaj S
- Bhardwaj S
- Bhayani L
- Bi G
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- Bilkovski R
- Binda K
- Binley J
- Bisht M
- Bisignano A
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- Blick G
- Blumenthal S
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- Boivin M
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- Bonnington O
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- Bonzela J
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- Borkird T
- Borquez A
- Bose M
- Bosomprah S
- Bouchaud O
- Boulle A
- Boum Y
- Bouzas M
- Bowman B
- Boyd A
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- Boyer S
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- Boyes M
- Bozinoff N
- Bozzi G
- Bradley J
- Brahmbhatt H
- Brainard D
- Brand R
- Bredeek U
- Brenchley J
- Brennan A
- Brennan A
- Brennan A
- Brennan C
- Brennan D
- Brewster-Lee D
- Brezak A
- Brigham F
- Brigstock-Barron O
- Brill I
- Brill I
- Brittain K
- Britto P
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brocca-Cofano E
- Brooks R
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- Brothers J
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- Bucek A
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- Bukenya D
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- Bukowski L
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- Burgener A
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- Burman W
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- Bwakura-Dangarembizi M
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- Carolus G
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated