The Flexible Company Innovation, Work Organisation and Human Ressource Management

This paper analyses the DISKO survey data on 1,900 firms within the Danish private business sector in terms of an index which classifies the surveyed firms according to smaller and higher degrees of flexibility. The classification reveals a number of important differences between more or less flexible firms. The more flexible firms tend to combine technical and organisational innovation to a larger extent than the less flexible firms and consequently are more inclined to employ new work organisation principles based on the delegation of authority, intrafirm horisontal and vertical integration, and the development of human resources. Similarly, the more flexible firms exhibit a larger inclination to extend their extraorganisational cooperative relationships. Finally, there is a strong positive correlation between increasing degrees of flexibility and increasing firm size, measured in terms of full-time employees. This paper was originally prepared for the International Conference on Changing workplace strategies: achieving better outcomes for enterprises, workers and society, organised by OECD in cooperation with Human Resource Development Canada at Chateau Laurier, Ottawa, 2-3 December 1996. We acknowledge the assistance of Birgitta Jacobsen, who made the data available.Organisational learning, innovation, flexibility

The impact of consanguinity on the frequency of inborn errors of metabolism

Inborn errors of metabolism (IEM) are a heterogeneous group of genetic disorders present in all ethnic groups. We investigated the frequency of consanguinity among parents of newborns with IEM diagnosed by neonatal screening.Data were obtained from 15years of expanded newborn screening for selected IEM with autosomal recessive mode of inheritance, a national screening program of newborns covering the period from 2002 until April 2017. Among the 838,675 newborns from Denmark, the Faroe Islands and Greenland, a total of 196 newborns had an IEM of whom 155 from Denmark were included in this study. These results were crosschecked against medical records. Information on consanguinity was extracted from medical records and telephone contact with the families.Among ethnic Danes, two cases of consanguinity were identified in 93 families (2.15%). Among ethnic minorities there were 20 cases of consanguinity among 33 families (60.6%). Consequently, consanguinity was 28.2 times more frequent among descendants of other geographic place of origin than Denmark. The frequency of consanguinity was conspicuously high among children of Pakistani, Afghan, Turkish and Arab origin (71.4%). The overall frequency of IEM was 25.5 times higher among children of Pakistani, Turkish, Afghan and Arab origin compared to ethnic Danish children (5.35:10,000 v 0.21:10,000). The frequency of IEM was 30-fold and 50-fold higher among Pakistanis (6.5:10,000) and Afghans (10.6:10,000), respectively, compared to ethnic Danish children.The data indicate a strong association between consanguinity and IEM. These figures could be useful to health professionals providing antenatal, pediatric, and clinical genetic services. Keywords: Inherited metabolic disease, Consanguinity, Ethnic group, Neonatal screenin

Socioeconomic position and depression in South African adults with long term health conditions: a longitudinal study of causal pathways

Aims. There is convincing evidence that lower socioeconomic position is associated with increased risk of mental disorders. However, the mechanisms involved are not well understood. This study aims to elucidate the causal pathways between socioeconomic position and depression symptoms in South African adults. Two possible causal theories are examined: social causation, which suggests that poor socioeconomic conditions cause mental ill health; and social drift, which suggests that those with poor mental health are more likely to drift into poor socioeconomic circumstances.Methods. The study used longitudinal and cross-sectional observational data on 3904 adults, from a randomised trial carried out in 38 primary health care clinics between 2011 and 2012. Structural equation models and counterfactual mediation analyses were used to examine causal pathways in two directions. First, we examined social causation pathways, with language (a proxy for racial or ethnic category) being treated as an exposure, while education, unemployment, income and depression were treated as sequential mediators and outcomes. Second, social drift was explored with depression treated as a potential influence on health-related quality of life, job loss and, finally, income.Results. The results suggest that the effects of language on depression at baseline, and on changes in depression during follow-up, were mediated through education and income but not through unemployment. Adverse effects of unemployment and job loss on depression appeared to be mostly mediated through income. The effect of depression on decreasing income appeared to be mediated by job loss.Conclusions. These results suggest that both social causation and social selection processes operate concurrently. This raises the possibility that people could get trapped in a vicious cycle in which poor socioeconomic conditions lead to depression, which, in turn, can cause further damage to their economic prospects. This study also suggests that modifiable factors such as income, employment and treatable depression are suitable targets for intervention in the short to medium term, while in the longer term reducing inequalities in education will be necessary to address the deeply entrenched inequalities in South Africa

Precision Measurement of Trident Production in Strong Electromagnetic Fields

We demonstrate experimentally that the trident process $e^-\rightarrow e^-e^+e^-$ in a strong external field, with a spatial extension comparable to the effective radiation length, is well understood theoretically. The experiment, conducted at CERN, probes values for the strong field parameter $\chi$ up to 2.4. Experimental data and theoretical expectations using the Local Constant Field Approximation show remarkable agreement over almost 3 orders of magnitude in yield.Comment: 4 pages, 2 figure

Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records:phenotypes, population prevalence, trends and prognosis

AIMS: To evaluate population-based electronic health record (EHR) definitions of atrial fibrillation (AF) and valvular heart disease (VHD) subtypes, time trends in prevalence and prognosis. METHODS AND RESULTS: A total of 76 019 individuals with AF were identified in England in 1998-2010 in the CALIBER resource, linking primary and secondary care EHR. An algorithm was created, implemented, and refined to identify 18 VHD subtypes using 406 diagnosis, procedure, and prescription codes. Cox models were used to investigate associations with a composite endpoint of incident stroke (ischaemic, haemorrhagic, and unspecified), systemic embolism (SSE), and all-cause mortality. Among individuals with AF, the prevalence of AF with concomitant VHD increased from 11.4% (527/4613) in 1998 to 17.6% (7014/39 868) in 2010 and also in individuals aged over 65 years. Those with mechanical valves, mitral stenosis (MS), or aortic stenosis had highest risk of clinical events compared to AF patients with no VHD, in relative [hazard ratio (95% confidence interval): 1.13 (1.02-1.24), 1.20 (1.05-1.36), and 1.27 (1.19-1.37), respectively] and absolute (excess risk: 2.04, 4.20, and 6.37 per 100 person-years, respectively) terms. Of the 95.2% of individuals with indication for warfarin (men and women with CHA2DS2-VASc ≥1 and ≥2, respectively), only 21.8% had a prescription 90 days prior to the study. CONCLUSION: Prevalence of VHD among individuals with AF increased from 1998 to 2010. Atrial fibrillation associated with aortic stenosis, MS, or mechanical valves (compared to AF without VHD) was associated with an excess absolute risk of stroke, SSE, and mortality, but anticoagulation was underused in the pre-direct oral anticoagulant (DOAC) era, highlighting need for urgent clarity regarding DOACs in AF and concomitant VHD

Differential Measurement of Trident Production in Strong Electromagnetic Fields

In this paper, we present experimental results and numerical simulations of trident production, $e^-\rightarrow e^-e^+e^-$, in a strong electromagnetic field. The experiment was conducted at CERN for the purpose of probing the strong-field parameter $\chi$ up to 2.4, using a 200 GeV electron beam penetrating a 400 $\mu$m thick germanium crystal oriented along the $\langle 110\rangle$ axis. For the current experimental parameters we found that the trident process is primarily a two-step process, and show remarkable agreement between theoretical predictions and experimental data. This paper is an extension of the previously published paper (Phys. Rev. Lett. 130, 071601 (2023)) and features new analysis differential in the energy of the produced positron and electron in the trident process. Even for the more demanding differential analysis, we find good agreement between theoretical predictions and experimental data, while a slight discrepancy is found in the high energy tail of the trident spectrum. This discrepancy could be an indication of the direct process, but further investigation is needed due to the large uncertainties in this part of the spectrum. Finally we present a suggestion for a future experiment, aiming to probe the direct process using thin crystals

Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial

Objectives To study the effect of insulin treatment in combination with metformin or an insulin secretagogue, repaglinide, on glycaemic regulation in non-obese patients with type 2 diabetes

4D characterization of metals by 3DXRD

31st Riso International Symposium on Materials Science, Roskilde, DENMARK, SEP 06-10, 2010International audienceThe status of 3DXRD microscopy is reviewed, with a special view to applications in metallurgy. Various approaches are compared in terms of perfounance. In addition several recent advances are presented, such as a 3D grain map with an unprecedented spatial resolution of 500 nm, first results from the commissioning of a novel 3D detector set-up and a validation of the box-scan procedure