Research on rare diseases:ten years of progress and challenges at IRDiRC

The International Rare Diseases Research Consortium (IRDiRC) is a global collaborative initiative launched in 2011, aimed at tackling rare diseases through research. Here, we summarize IRDiRC’s vision and goals and highlight achievements and prospects after its first decade.</p

Теоретичне прогнозування критичних станів вертикальних колон надглибинного буріння

Поставлена задача об устойчивости и свободных колебаниях глубоких вращающихся бурильных колонн, которые преднапряжены продольной силой и крутящим моментом. С учетом статических и динамических эффектов силового взаимодействия указанных механических факторов построены разрешающие уравнения. Предложена методика их решения, основанная на применении метода продолжения по параметру и метода ортогонализации. Выполнены исследования устойчивости и колебаний бурильных колонн длиной до 10000 мThe problem about free vibrations of rotating drill columns prestressed by torque and longitudinal force is stated. The constitutive equations are formulated with allowance made for static and dynamic effects of force interaction betwen the mentioned factors. The techniques of the equation integration are proposed, wich are based on application of the transfer matrix method and the orthogonalization method. The investigations of stability and vibrations of the 10 km length drill strings are performed

First-level trigger systems for LHC experiments

We propose to carry out a broad-based programme of R&D on level-1 trigger systems for LHC experiments. We will consider the overall level-1 which coordinates different subtriggers and which interacts with the front end electronics and with the level-2 system. Careful attention will be paid to systems aspects and problems of synchronization within the pipelined processor system. Trigger algorithms for selecting events with high-pt electrons, photons, muons, jets and large missing Et will be evaluated by physics simulation studies. We will study possible implementations of such trigger algorithms in fast electronics by making conceptual design studies and using behavioural simulation models. For critical areas more detailed design studies will be made, and prototypes of some key elements will be constructed and tested. The proposed R&D project builds on existing studies and will complement other R&D projects already funded by the DRDC