Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines

The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[3]- benzazepine is a common skeleton in a number of natural and pharmaceutical products. As consequence of the interesting biological properties, derivatives of the tetrahydro-1H-[3]-benzazepines, especially the 1-aryl substituted have been synthesized by different routes and evaluated their pharmacologic activity. [1,2] The stereoselective synthetic approaches of tetrahydro-1H-[3]-benzazepine have focused on ring enlargements, as the Stevens rearrangement (SR) which is a good regio- and diastereoselective synthetic methodology. In my research group, the reaction conditions to synthesize tetrahydro-1H-[3]-benzazepines 1,2-disubstituted by via SR from tetrahydroisoquinolinium salts conveniently functionalized have been optimized. [3,4] This methodology allowed us to obtain a wide variety of tetrahydro-1H-[3]- benzazepines 1,2-disubstituted with different substituents at A-ring (Cl, OMe) and the C-1 (-C6H4X, X = H, OMe, Cl, NO2, NMe2, NH2, SMe) and C-2 (Electron-withdrawing groups) positions. The demethylation of the synthesized tetrahydroisoquinolines and tetrahydro-1H-[3]-benzazepines 1,2-disubstituted, lead us to get catechol structure, an important requirement for their dopaminergic activity. We have studied the dopaminergic activity of the synthesized compounds by radioligand binding assays, establishing a structure-activity relationships. Literature: [1] A. Gini, Adv. Synth. Catal. 2016, 358, 4049. [2] H. Damsen, Eur. J. Org. Chem. 2015, 36, 7880. [3] M. Valpuesta, Eur. J. Org. Chem. 2010, 23, 4393. [4] M. Ariza, Eur. J. Org. Chem. 2011, 32, 6507.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Synthesis of bioactive compounds. Studies of their attachment to nanoparticles

The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of 1-aryl tetrahydroisoquinoline are used for the treatment of neurodegenerative diseases such as Parkinson´s and Alzheimer´s diseases since also act as dopaminergic antagonists and N-methyl-D-aspartate receptor antagonist. [1] The 1-substituted tetrahydro-3-benzazepines have also been studied for their affinity to the Phencylclidine binding site of the NMDA receptor as well as for their affinity to the dopaminergic receptors. [2] In the last years, various methods have been carried out to satisfy the demand of novel tetrahydroisoquinolines and tetrahydro-3-benzazepines. We have synthesized nor-1-aryl tetrahydroisoquinolines with different substituents in the aryl group of C-1 (H, NMe2, SMe, NO2, NH2). In addition to this, we have performed the synthesis of nor-tetrahydro-3-benzazepinas by different routes, obtaining the best results via opening of epoxides by arylphenethylamines and subsequent cyclization. The nor-tetrahydroisoquinolines and nor-tetrahydro-3-benzazepines have been derivatized to obtain appropiate adsorbates which can be attached to nanoparticles. This fact is crutial in drug delivery systems as well as in the improvement of the biocompatibility of these compounds. Literature: [1] Toshiaki Saitoh, Eur. J. Med. Chem. 2006, 41, 241. Mattias Ludwig, Eur. J. Med. 2006, 41, 1003. [2] Olaf Krull, Bioorg. Med. Chem. 2004, 12, 1439.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

The Influence of Connecting Funds of Knowledge to Beliefs about Performance, Classroom Belonging

First-generation college students in engineering accumulate bodies of knowledge through their working-class families. In our ethnographic data of first-generation college students, we identified tinkering knowledge from home and from work, perspective taking, mediational ability, and connecting experiences as knowledge sources brought to engineering. The purpose of this paper was to understand how first-generation college students’ accumulated bodies of knowledge (i.e., funds of knowledge) support their beliefs about performing well in engineering coursework, feeling a sense of belonging in the classroom, and certainty of graduating. Data for this study came from a survey administered in the Fall of 2018 from ten universities across the US. In this study, only the sample of students who indicated their parents had less than a bachelor’s degree (n = 378) were used. A structural equation modeling technique was employed to examine several interconnected research questions pertaining to funds of knowledge, performance/competence beliefs, classroom belongingness, and certainty of graduating with an engineering degree. Our analysis demonstrates that the accumulated bodies of knowledge obtained through tinkering at home, tinkering at work, and the skill of being a mediator served to scaffold concepts that students were currently learning in engineering. There was a negative direct relationship between students’ ability to make connections between their home activities to scaffold what they are currently learning and their certainty of graduating with an engineering degree. However, first-generation college students’ perceptions of performing well in their engineering coursework and their sense of belonging in the classroom positively supported their certainty of graduating thus emphasizing the importance of connecting students’ funds of knowledge to engineering coursework and classroom instruction. Implications for possible approaches towards connecting first-generation college students’ funds of knowledge to engineering coursework and classroom culture are discussed

Automated Network Service Scaling in NFV: Concepts, Mechanisms and Scaling Workflow

Next-generation systems are anticipated to be digital platforms supporting innovative services with rapidly changing traffic patterns. To cope with this dynamicity in a cost-efficient manner, operators need advanced service management capabilities such as those provided by NFV. NFV enables operators to scale network services with higher granularity and agility than today. For this end, automation is key. In search of this automation, the European Telecommunications Standards Institute (ETSI) has defined a reference NFV framework that make use of model-driven templates called Network Service Descriptors (NSDs) to operate network services through their lifecycle. For the scaling operation, an NSD defines a discrete set of instantiation levels among which a network service instance can be resized throughout its lifecycle. Thus, the design of these levels is key for ensuring an effective scaling. In this article, we provide an overview of the automation of the network service scaling operation in NFV, addressing the options and boundaries introduced by ETSI normative specifications. We start by providing a description of the NSD structure, focusing on how instantiation levels are constructed. For illustrative purposes, we propose an NSD for a representative NS. This NSD includes different instantiation levels that enable different ways to automatically scale this NS. Then, we show the different scaling procedures the NFV framework has available, and how it may automate their triggering. Finally, we propose an ETSI-compliant workflow to describe in detail a representative scaling procedure. This workflow clarifies the interactions and information exchanges between the functional blocks in the NFV framework when performing the scaling operation.Comment: This work has been accepted for publication in the IEEE Communications Magazin

Funds of Knowledge as Pre-College Experiences that Promote Minoritized Students’ Interest, Self-Efficacy Beliefs, and Choice of Majoring in Engineering

Pre-college experiences both inside and outside of the classroom inform students’ interest in science, technology, engineering, and mathematics (STEM)-related activities, help them evaluate their knowledge and skills in various tasks, and shape their perceptions of themselves as individuals who can participate in STEM. Yet little empirical research examines the valuable pre-college knowledge, practices, and skills that minoritized students acquire through their home experiences and how they can support students’ transition into an engineering pathway. This study addresses this gap by investigating how students’ funds of knowledge support their interest in engineering, self-efficacy beliefs, and certainty of pursuing an engineering major. Data for this study came from a diverse group of first-year engineering students. A serial mediation analysis confirmed that first-year students’ tinkering knowledge from home supports their beliefs about doing well in their engineering coursework, which in turn helps their certainty of majoring in engineering. Seeing a connection between experiences at home and what is being taught in engineering coursework and the ability to draw from home experiences to solve an engineering task supported minoritized students’ self-efficacy beliefs, interest, and certainty of majoring in engineering. Our study demonstrates how diverse first-year engineering students’ everyday household knowledge and skills serve as assets for pursuing an engineering degree. Practical strategies are discussed to promote minoritized students’ funds of knowledge (i.e., tinkering knowledge from home, perspective taking, and mediational skills) to science practices and the engineering design process outlined in the Next Generation Science Standards

Cartografía Oficial Versus Datos OpenSource

El presente documento se trata de un proyecto de investigación titulado “Cartografía Oficial Versus Datos Opensource”. Realizado por Juan José Jiménez Lucena y coordinado por la profesora de ingeniería Elisabete Monteiro. Realizado en la Escuela Superior de Tecnología perteneciente al Instituto Politécnico de Guarda, en Guarda (Portugal). Se trata de un proyecto ubicado en la rama de la Cartografía y de los Sistemas de Información Geográfica. El objetivo es realizar una comparación de la cartografía de libre acceso con la cartografía oficial producida por la institución correspondiente. El documento se divide en varias partes, la primera de ella se trata de un estudio de la cartografía oficial de Portugal. Dicha cartografía es toda de pago. Es realizada por dos instituciones oficiales que realizan cartografía de base y cartografía temática, más tres servicios más que se dedican exclusivamente a la producción de cartografía temática. El ámbito de tal cartografía es Portugal Continental, los archipiélagos de Madeira y Azores y las antiguas colonias portuguesas. La siguiente parte del documento es un caso de estudio donde el objetivo es comparar las diferencias de la cartografía de libre acceso con la cartografía oficial en una región escogida para el área de estudio. En este caso la cartografía oficial es la de Reino Unido y la empresa que produce la cartografía de libre acceso también es nacida allí. El caso de estudio se sitúa en un condado de Reino Unido llamado West Midlands. Ambas cartografías fueron estudiadas en un software de Información Geográfica. Para cuantificar las diferencias de capas lineares, como líneas férreas o río, entre ambas mido los parámetros de las longitudes totales, en capas areales, como por ejemplo los edificios, se mide y compara el área. Es realizado un análisis de la compleción, todo ellos, con las herramientas de las que disponen los software SIG. Para cuantificar las diferencias se utilizan tablas donde se presentan los datos numéricos siempre con el apoyo gráfico obtenido de los SIG. Los softwares utilizados son dos, uno de pago y otro de libre acceso. Con el software de libre acceso realizo todas las operaciones menos una, las transformaciones de datos entre Sistemas, que las realizo con el software de pago. Las transformaciones y todas las operaciones realizadas las detallo en su correspondiente momento. Tras obtener las diferencias de la cartografía de libre acceso con la cartografía oficial, se intenta llegar al motivo de estas diferencias relatado en las conclusiones

Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors

The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high affinity and selectivity of this tetrahydro-1H-[3]-benzazepine has led to the search for new structures because of their potential dopaminergic activity, especially 1-aryl-substituted tetrahydro-1H-[3]-benzazepines. Furthermore, their precursors, the tetrahydroisoquinolines 1-substituted have shown to have activity for D1 and D2 dopaminergic receptors.[2] We have carried out the synthesis of tetrahydro-1H-[3]-benzazepines 1,2-di-substituted by Stevens rearrangement (SR) on tetrahydroisoquinolinium salts. Stevens rearrangement is an efficient regio- and diastereoselective synthetic methodology. [3a,b] As part of our studies, we have performed the synthesis of benzazepines with modifications at the C-1 and C-2 positions with chlorine and hydroxyl groups at A-ring which is an important factor to modulate affinity at dopaminergic receptors. The interaction of these molecules with D1 and D2 dopaminergic receptors have been studied to establish a structure-activity relationship by radioligand binding assays.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Study and characterization of modified silicon surfaces with organic molecules

Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows specific interactions with biomolecules and presents several advantages like greater detection sensitivity and stability against hydrolytic cleavage.1 In this sense, to control the orientation and spacing between grafted functional moieties on the surface, tripodal oligo (p-phenylene)s have become ideal anisotropic adsorbates due to their shape-persistent and selfstanding characteristics.2 On the other hand, biomolecules such as tehtahydro[3]benzazepines are well-known to contain in their structure a phenetylamine skeleton, which is also present in dopaminergic receptors and drugs, therefore these molecules have a remarkable interest in medicinal chemistry. Here we report the synthesis and characterization of several tetrahydro[3]benzazepines and tripod-shaped oligo(p-phenylene)s which were suitably functionalized for its subsequent adsorption on silicon surfaces by hydrosilylation and/or CuAAc click reaction. X-ray photoemission spectroscopy (XPS) and atomic force microscopy (AFM) analysis were also carried out to reveal the presence of the grafted molecules on the different Si surfaces.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech