Mixed Proper Orthogonal Decomposition with Harmonic Approximation for Parameterized Order Reduction of Electromagnetic Models

This paper presents some preliminary investigations on a hybrid Model Order Reduction approach for parameter-dependent electromagnetic systems. Starting from an integral equation formulation of the field problem, we introduce a first level of compression based on the well-established Proper Orthogonal Decomposition (POD). The result is a small-scale approximation of the full-order discrete field formulation, which retains an explicit dependence on the set of free parameters defining the geometry. The evaluation of the reduced model for arbitrary parameter configurations remains very expensive, as it requires the construction of the full system equations before its projection onto a lower-dimensional space. This problem is solved by constructing a surrogate macromodel of the parameterized reduced-order system through a multivariate Fourier approximation. Numerical results applied to a moving coil over a finite ground plane show model compression above 99% while preserving accuracy on currents and fields within 1%

Modeling Non-Premixed Combustion Using Tabulated Kinetics and Different Fame Structure Assumptions

Nowadays, detailed kinetics is necessary for a proper estimation of both flame structure and pollutant formation in compression ignition engines. However, large mechanisms and the need to include turbulence/chemistry interaction introduce significant computational overheads. For this reason, tabulated kinetics is employed as a possible solution to reduce the CPU time even if table discretization is generally limited by memory occupation. In this work the authors applied tabulated homogeneous reactors (HR) in combination with different turbulent-chemistry interaction approaches to model non-premixed turbulent combustion. The proposed methodologies represent good compromises between accuracy, required memory and computational time. The experimental validation was carried out by considering both constant-volume vessel and Diesel engine experiments. First, the ECN Spray A configuration was simulated at different operating conditions and results from different flame structures are compared with experimental data of ignition delay, flame lift-off, heat release rates, radicals and soot distributions. Afterwards, engine simulations were carried out and computed data are validated by cylinder pressure and heat release rate profiles

Primary breast lymphoma: case reports and review of the literature

As the prevalence of breast cancer has increased over recent years many cases with unusual presentation are emerging. This revue attempts to identify different types of primary malignancies that can affect the breast. A five years review was undertaken at the Breast Unit of Azienda Ospedaliera “Santa Maria”, Terni (Italy). All cases of breast malignancy admitted to the Breast Unit between 2001 and 2005 were reviewed: 750 patients were diagnosed with malignant breast disease. Primary breast lymphoma (was found only in two cases accounting for an incidence of 0,26%. The pre-operative diagnosis was infiltrating carcinoma in both cases and the patients were treated with surgery and systemic chemotherapy; currently they are disease-free

Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson's Disease in the Province of Brescia, Italy

Environmental exposures to agrochemicals and nutritional factors may be associated with Parkinson's Disease (PD). None of the studies to date has examined the combined effects of diet and agricultural chemical exposure together. To address these research gaps, we aimed to assess the association of nutritional factors and agrochemical exposure with the risk of PD. A hospital-based case-control study was conducted. Multivariable logistic regressions were used to estimate the association of nutritional and agrochemical exposures with PD, adjusting for gender, age, socio-economic status, head injury, family history, smoking, metals exposure, and alpha-synuclein gene polymorphism. Weighted Quantile Sum (WQS) regression was applied to examine the effect of dietary components as a mixture. We recruited 347 cases and 389 controls. Parent history of PD (OR = 4.15, 95%CI: 2.10, 8.20), metals exposure (OR = 2.50, 95%CI: 1.61-3.89), SNCA rs356219 polymorphism (OR = 1.39, 95%CI: 1.04-1.87 for TC vs. TT; OR = 2.17, 95%CI: 1.43-3.28 for CC vs. TT), agrochemical exposures (OR = 2.11, 95%CI: 1.41-3.16), and being born in the Brescia province (OR = 1.83, 95%CI: 1.17-2.90) were significantly associated with PD. Conversely, fish intake and coffee consumption had a protective effect. The study confirmed the role of environmental exposures in the genesis of PD. Fish intake and coffee consumption are protective factors even when agricultural chemical exposures exist. Genetic factors and metals exposure were confirmed as risk factors for PD

Combined Experimental and Numerical Investigation of the ECN Spray G under Different Engine-Like Conditions

A detailed understanding of Gasoline Direct Injection (GDI) techniques applied to spark-ignition (SI) engines is necessary as they allow for many technical advantages such as increased power output, higher fuel efficiency and better cold start performances. Within this context, the extensive validation of multi-dimensional models against experimental data is a fundamental task in order to achieve an accurate reproduction of the physical phenomena characterizing the injected fuel spray. In this work, simulations of different Engine Combustion Network (ECN) Spray G conditions were performed with the Lib-ICE code, which is based on the open source OpenFOAM technology, by using a RANS Eulerian-Lagrangian approach to model the ambient gas-fuel spray interaction. Foremost, the main scope of the activity was to identify the most accurate numerical set-up in terms of atomization ad secondary break-up models, thanks to a validation of the computed results against experimental data available for the ECN Spray G baseline condition. Specifically, attention was focused on spray penetration along with an analysis of spray morphology and effects of plume-to-plume interaction. Afterwards, the reference set-up was tested and validated under different operating conditions, characterized by detailed experimental measurements specifically provided for this work. In particular, Mie scattering and Schlieren techniques allowed the quasi-simultaneous acquisition of both vapor and liquid penetrations, while a customized image-processing procedure, developed in Matlab environment, was used for the outline of the spray contours of both fuel phases to measure the parameters characterizing the jet development. A robust reference numerical set-up was identified, capable to reproduce with good accuracy the injection process of a multi-hole GDI spray under the wide range of tested operating conditions

Platelet-Lysate-Expanded Mesenchymal Stromal Cells for the Treatment of Resistant GVHD

n/

Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation

Mesenchymal stromal cells (MSC) are tested in clinical trials to treat graft versus host disease (GvHD) after stem cell transplantation (SCT). In vitro studies demonstrated MSC's broad immunosuppressive activity. As infections represent a major risk after SCT, it is important to understand the role of MSC in this context. We analyzed 24 patients (pts) receiving MSC for GvHD in our Unit between 2009 and 2011. We recorded viral reactivations as measured in whole blood with polymerase chain reaction for 100 days following MSC administration. In patients with a documented viral reactivation in the first 3 days following MSCs infusion the frequency of virus-specific IFNgamma-producing cells was determined through enzyme-linked immunospot assay. In our cohort of patients viral reactivation after MSC infusion occurred in 45% of the cases, which did not significantly differ from the incidence in a historical cohort of patients affected by steroid resistant GvHD and treated with conventional immunosuppression. No patient presented severe form of infection. Two cases could be checked for immunological response to viral stimulus and demonstrated virus specific T-cytotoxic lymphocyte activity. In our experience MSC infusion did not prove to trigger more frequent or severer viral reactivations in the post transplantation setting

Efficient aberrations pre-compensation and wavefront correction with a deformable mirror in the middle of a petawatt-class CPA laser system

AbstractIn this paper, we describe the experimental validation of the technique of correction of wavefront aberration in the middle of the laser amplifying chain. This technique allows the correction of the aberrations from the first part of the laser system, and the pre-compensation of the aberrations built in the second part. This approach will allow an effective aberration management in the laser chain, to protect the optical surfaces and optimize performances, and is the only possible approach for multi-petawatt laser system from the technical and economical point of view. This approach is now possible after the introduction of new deformable mirrors with lower static aberrations and higher dynamic than the standard devices