Dynamic Provenance for SPARQL Update

While the Semantic Web currently can exhibit provenance information by using the W3C PROV standards, there is a "missing link" in connecting PROV to storing and querying for dynamic changes to RDF graphs using SPARQL. Solving this problem would be required for such clear use-cases as the creation of version control systems for RDF. While some provenance models and annotation techniques for storing and querying provenance data originally developed with databases or workflows in mind transfer readily to RDF and SPARQL, these techniques do not readily adapt to describing changes in dynamic RDF datasets over time. In this paper we explore how to adapt the dynamic copy-paste provenance model of Buneman et al. [2] to RDF datasets that change over time in response to SPARQL updates, how to represent the resulting provenance records themselves as RDF in a manner compatible with W3C PROV, and how the provenance information can be defined by reinterpreting SPARQL updates. The primary contribution of this paper is a semantic framework that enables the semantics of SPARQL Update to be used as the basis for a 'cut-and-paste' provenance model in a principled manner.Comment: Pre-publication version of ISWC 2014 pape

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

Maternal separation (MS) is an early life stress model that induces permanent changes in the central nervous system, impairing hippocampal long-term potentiation (LTP) and spatial working memory. There are compelling evidences for a role of hippocampal adenosine A(2A) receptors in stress-induced modifications related to cognition, thus opening a potential window for therapeutic intervention. Here, we submitted rats to MS and evaluated the long-lasting molecular, electrophysiological and behavioral impairments in adulthood. We then assessed the therapeutic potential of KW6002, a blocker of A(2A) receptors, in stress-impaired animals. We report that the blockade of A(2A) receptors was efficient in reverting the behavior, electrophysiological and morphological impairments induced by MS. In addition, this effect is associated with restoration of the hypothalamic-pituitary-adrenal axis (HPA-axis) activity, as both the plasma corticosterone levels and hippocampal glucocorticoid receptor expression pattern returned to physiological-like status after the treatment. These results reveal the involvement of A(2A) receptors in the stress-associated impairments and directly in the stress response system by showing that the dysfunction of the HPA-axis as well as the long-lasting synaptic and behavioral effects of MS can be reverted by targeting adenosine A(2A) receptors. These findings provide a novel evidence for the use of adenosine A(2A) receptor antagonists as potential therapy against psychopathologiesWe acknowledge Alexandre de Mendonca, David Blum and Rodrigo Cunha for helpful discussions. VLB is thankful to Joao Baiao and Carla Batalha for technical assistance. VLB has been awarded a PhD fellowship from Fundacao para a Ciencia e Tecnologia (BD/63041/2009). LVL is funded by Fundacao para a Ciencia e Tecnologia (PTDC/SAU-NEU/099853/2008) and by EU programme Egide-Pessoa. YB and CEM were funded by the Ministry for Education and Research (BMBF, Grant number 01EW0911) in the frame of ERA-NET NEURON

Haematological assessment of four amazonian ornamental armoured catfish (Teleostei, Loricariidae).

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Charge Ordering and Ferroelectricity in Half-doped Manganites

By means of density-functional simulations for half-doped manganites, such as pseudocubic Pr0.5Ca0.5MnO3 and bilayer PrCa2Mn2O7, we discuss the occurrence of ferroelectricity and we explore its crucial relation to the crystal structure and to peculiar charge/spin/orbital ordering effects. In pseudocubic Pr0.5Ca0.5MnO3, ferroelectricity is induced in the Zener polaron type structure, where Mn ions are dimerized. In marked contrast, in bilayer PrCa2Mn2O7, it is the displacements of apical oxygens bonded to either Mn3+ or Mn4+ ions that play a key role in the rising of ferroelectricity. Importantly, local dipoles due to apical oxygens are also intimately linked to charge and orbital ordering patterns in MnO2 planes, which in turn contribute to polarization. Finally, an important outcome of our work consists in proposing Born effective charges as a valid mean to quantify charge disproportionation effects, in terms of anisotropy and size of electronic clouds around Mn ions.Comment: 5 pages, 2 figures, submitted for publicatio

5D Attractors with Higher Derivatives

We analyze higher derivative corrections to attractor geometries in five dimensions. We find corrected AdS_3xS^2 geometries by solving the equations of motion coming from a recently constructed four-derivative supergravity action in five dimensions. The result allows us to explicitly verify a previous anomaly based derivation of the AdS_3 central charges of this theory. Also, by dimensional reduction we compare our results with those of the 4D higher derivative attractor, and find complete agreement.Comment: 18 pages, harvma

Traveling waves for nonlinear Schr\"odinger equations with nonzero conditions at infinity, II

We prove the existence of nontrivial finite energy traveling waves for a large class of nonlinear Schr\"odinger equations with nonzero conditions at infinity (includindg the Gross-Pitaevskii and the so-called "cubic-quintic" equations) in space dimension $N \geq 2$. We show that minimization of the energy at fixed momentum can be used whenever the associated nonlinear potential is nonnegative and it gives a set of orbitally stable traveling waves, while minimization of the action at constant kinetic energy can be used in all cases. We also explore the relationship between the families of traveling waves obtained by different methods and we prove a sharp nonexistence result for traveling waves with small energy.Comment: Final version, accepted for publication in the {\it Archive for Rational Mechanics and Analysis.} The final publication is available at Springer via http://dx.doi.org/10.1007/s00205-017-1131-

Portuguese Sorraia horse dynamics study with innovative technology: stance and swing of the walk

Apresentação em painelSorraia horse is an endangered native primitive breed from Portugal, highly inbred with a small census of around 300 animals worldwide. The aim of the study was to present the difference between stance (St) and swing (Sw), when the limbs are moving on the ground or in the air, respectively, during stride duration. Results were obtained for the total, forelimbs and hindlimbs, left and right sides, and each limb separately. Using innovative technology (EquiMoves), six Sorraia stallions were studied for the variables St and Sw (complete stride duration) at medium Walk. The averages of the variables for a complete stride duration (1.16±0.10 s) were 0.70±0.08 s (St) and 0.46±0.02 (Sw), for the forelimbs, 0.72±0.09 s (St) and 0.44±0.03 (Sw), for hindlimbs 0.69±0.08 s (St) and 0.47±0.02 (Sw), for the left side of 0.71±0.09 s (St) and 0.45±0.03 (Sw), and for the right side 0.70±0.07 s (St) and 0.46±0.02 (Sw). The distribution by four limbs was, for left front 0.71±0.09 s (St) and 0.45±0.03 (Sw), right front 0.72±0.08 s (St) and 0.44±0.02 (Sw), left hind 0.69±0.08 s (St) and 0.47±0.02 (Sw) and right hind 0.68±0.06 s (St) and 0.48±0.01 (Sw). Differences between variables St and Sw were significant (p-v<0.05), indicating that, on average, stride duration of Sorraias stallions is distributed by 60.6% with the limb on the ground (St) and 39.4% with the limb in the air (Sw). On the other hand, the differences within the variables were not significant (p-v>0.05) for the forelimbs, hindlimbs, both sides and isolated limbs. The analysis of the medium Walk for variables St and Sw from Sorraia stallions, indicated that, for a complete stride duration, limbs spend more time on the ground and present identical distribution among all limbs. Sorraia horses are animals with a balanced and symmetrical distribution of the Walk. New studies, including trot and canter, will allow to better understand the distribution of the variables St and Sw for Sorraia horse dynamics and possible differences for the Walk.info:eu-repo/semantics/publishedVersio

Refining the phenotype associated with biallelic DNAJC21 mutations

Accepted manuscriptInherited bone marrow failure syndromes (IBMFS) are caused by mutations in genes involved in genomic stability. Although they may be recognized by the association of typical clinical features, variable penetrance and expressivity are common, and clinical diagnosis is often challenging. DNAJC21, which is involved in ribosome biogenesis, was recently linked to bone marrow failure. However, the specific phenotype and natural history remain to be defined. We correlate molecular data, phenotype, and clinical history of 5 unreported affected children and all individuals reported in the literature. All patients present features consistent with IBMFS: bone marrow failure, growth retardation, failure to thrive, developmental delay, recurrent infections, and skin, teeth or hair abnormalities. Additional features present in some individuals include retinal abnormalities, pancreatic insufficiency, liver cirrhosis, skeletal abnormalities, congenital hip dysplasia, joint hypermobility, and cryptorchidism. We suggest that DNAJC21-related diseases constitute a distinct IBMFS, with features overlapping Shwachman-Diamond syndrome and Dyskeratosis congenita, and additional characteristics that are specific to DNAJC21 mutations. The full phenotypic spectrum, natural history, and optimal management will require more reports. Considering the aplastic anemia, the possible increased risk for leukemia, and the multisystemic features, we provide a checklist for clinical evaluation at diagnosis and regular follow-up.FCT—Fundação para a Ciência e a Tecnologia (SFRH/BD/84650/2010)info:eu-repo/semantics/publishedVersio