Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options

Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was granted approval for treatment of moderate-to-severe AD. Biologics targeting IgE/Th2 pathways may have its role in patients with overlapping AD and asthma. Psychological distress can exacerbate symptoms and is associated with increased severity of AD. Environmental triggers, such as, allergens can be addressed in selected cases with allergic immunotherapy. In this paper, we discuss AD treatment and propose a new step-by-step approach aiming at maintaining disease control and improving quality of life.info:eu-repo/semantics/publishedVersio

Economic Impacts of Ageing: An Interindustry Approach

Purpose - The purpose of this paper is to quantify the impact of the evolution of consumption patterns associated with ageing on the relative importance of industries in Portugal. Design/Methodology/Approach - This paper uses data from the Family Spending Survey to disaggregate the Household column of the Portuguese Input-Output Table in different age groups, projecting their consumption, using the latest demographic projections made by Statistics Portugal (INE). Findings - The study identifies the industries that are likely to be stimulated by the ageing of the Portuguese populations, as well as the industries that will most likely become disadvantaged by the process. Social implications - The task of identification of growing and declining industries due to ageing is important to help the design of employment, environmental, and social policies. Original/Value - The contemporary demographic trends in western societies have added to the importance of studying the economic and social consequences of ageing. Previously, the main issues have been the labour market effects, the sustainability of social security systems, and long-term care. In this paper, we address a different research topic, quantifying the sectoral impact of the evolution of consumption patterns associated with ageing.Ageing; Input-output; Consumption behaviour.

Large time behavior for vortex evolution in the half-plane

In this article we study the long-time behavior of incompressible ideal flow in a half plane from the point of view of vortex scattering. Our main result is that certain asymptotic states for half-plane vortex dynamics decompose naturally into a nonlinear superposition of soliton-like states. Our approach is to combine techniques developed in the study of vortex confinement with weak convergence tools in order to study the asymptotic behavior of a self-similar rescaling of a solution of the incompressible 2D Euler equations on a half plane with compactly supported, nonnegative initial vorticity.Comment: 30 pages, no figure

FAKTOR-FAKTOR YANG MEMPENGARUHI EFEKTIVITAS GABUNGAN KELOMPOK TANI (GAPOKTAN) DALAM PROGRAM PENGEMBANGAN USAHA AGRIBISNIS PERDESAAN (PUAP) DI KECAMATAN PEDAN KABUPATEN KLATEN

n this paper we give the full classification of curves $C$ of genus $g$ such that a Brill--Noether locus $W^ s_d(C)$, strictly contained in the jacobian $J(C)$ of $C$, contains a variety $Z$ stable under translations by the elements of a positive dimensional abelian subvariety $A\subsetneq J(C)$ and such that $\dim(Z)=d-\dim(A)-2s$, i.e., the maximum possible dimension for such a $Z$