13 research outputs found
A genome-scale shRNA resource for transgenic RNAi in Drosophila
Get PDFExisting transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during oogenesis, an important model system for the study of many biological questions. We show that shRNAs, modeled on an endogenous microRNA, are extremely effective at silencing gene expression during oogenesis. We also describe our progress toward building a genome-wide shRNA resource. © 2011 Nature America, Inc. All rights reserved
A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis
Get PDFStructural insights into the methyl donor recognition model of a novel membrane-binding protein UbiG
No full textDirect interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function
No full textStructure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen
No full textATP and MO25 alpha regulate the conformational state of the STRAD alpha pseudokinase and activation of the LKB1 tumour suppressor
Get PDFThe conformation of the pseudokinase STRADα, which is regulated by binding to ATP and to the scaffolding protein MO25α, is key to the activiation of the LKB1 tumor suppressor complex
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
No full textLinear Decay of Retrotransposon Antisense Bias across Genes Is Contingent upon Tissue Specificity
No full text
Functional and structural characterization of plastidic starch phosphorylase during barley endosperm development
No full text
