EFFICACY OF PNEUMATIC DILATATION FOR THE TREATMENT OF IDIOPATIC ACHALASIA: A SINGLE-CENTRE EXPERIENCE

Pneumatic dilatation (PD) and surgical miotomy (SM) are presentely the best treastments for untreated achalasia, with similar efficacy. There is no information on the relative efficacy of PD in younger compared to older patients. Aim of our study was to compare success rate and safety of PD patients under fifty years old in our Unit with graded PD under fluoroscopic view. Five male and 15 female with a median age of 47 years were treated. Twelve patients were less than fifthy years old (group I) while 8 were older (group II). Median dysphagia questionnaire score was 14 and 13 in group I and II respectively. Technical success was achieved in all patients. Seven patients were previously treated through other techniques. In group I all patients achieved a complete remission of symptoms with significant decrease of the dysphagia questionnaire (3). in group II all patients achieved a complete remissionof symptoms with significant decrease of the dysphagia questionnaire score (4,5) but 3 of them repeated the procedure. In boths groups the efficacy of the dilation was radiologically confirmed. Neither early nor late complications were reported in either groups. In our experience PD was an effective and safe procedure both in young and old patients although the older group had more recurrences, all successfully re-dilated

Revisiting Deniability in Quantum Key Exchange via Covert Communication and Entanglement Distillation

We revisit the notion of deniability in quantum key exchange (QKE), a topic that remains largely unexplored. In the only work on this subject by Donald Beaver, it is argued that QKE is not necessarily deniable due to an eavesdropping attack that limits key equivocation. We provide more insight into the nature of this attack and how it extends to other constructions such as QKE obtained from uncloneable encryption. We then adopt the framework for quantum authenticated key exchange, developed by Mosca et al., and extend it to introduce the notion of coercer-deniable QKE, formalized in terms of the indistinguishability of real and fake coercer views. Next, we apply results from a recent work by Arrazola and Scarani on covert quantum communication to establish a connection between covert QKE and deniability. We propose DC-QKE, a simple deniable covert QKE protocol, and prove its deniability via a reduction to the security of covert QKE. Finally, we consider how entanglement distillation can be used to enable information-theoretically deniable protocols for QKE and tasks beyond key exchange.Comment: 16 pages, published in the proceedings of NordSec 201

Revisiting Deniability in Quantum Key Exchange via Covert Communication and Entanglement Distillation

We revisit the notion of deniability in quantum key exchange (QKE), a topic that remains largely unexplored. In the only work on this subject by Donald Beaver, it is argued that QKE is not necessarily deniable due to an eavesdropping attack that limits key equivocation. We provide more insight into the nature of this attack and how it extends to other constructions such as QKE obtained from uncloneable encryption. We then adopt the framework for quantum authenticated key exchange, developed by Mosca et al., and extend it to introduce the notion of coercer-deniable QKE, formalized in terms of the indistinguishability of real and fake coercer views. Next, we apply results from a recent work by Arrazola and Scarani on covert quantum communication to establish a connection between covert QKE and deniability. We propose DC-QKE, a simple deniable covert QKE protocol, and prove its deniability via a reduction to the security of covert QKE. Finally, we consider how entanglement distillation can be used to enable information-theoretically deniable protocols for QKE and tasks beyond key exchange

Molecular and electrophysiological features of spinocerebellar ataxia type seven in induced pluripotent stem cells.

Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the ATXN7 gene. Patients with this disease suffer from a degeneration of their cerebellar Purkinje neurons and retinal photoreceptors that result in a progressive ataxia and loss of vision. As with many neurodegenerative diseases, studies of pathogenesis have been hindered by a lack of disease-relevant models. To this end, we have generated induced pluripotent stem cells (iPSCs) from a cohort of SCA7 patients in South Africa. First, we differentiated the SCA7 affected iPSCs into neurons which showed evidence of a transcriptional phenotype affecting components of STAGA (ATXN7 and KAT2A) and the heat shock protein pathway (DNAJA1 and HSP70). We then performed electrophysiology on the SCA7 iPSC-derived neurons and found that these cells show features of functional aberrations. Lastly, we were able to differentiate the SCA7 iPSCs into retinal photoreceptors that also showed similar transcriptional aberrations to the SCA7 neurons. Our findings give technical insights on how iPSC-derived neurons and photoreceptors can be derived from SCA7 patients and demonstrate that these cells express molecular and electrophysiological differences that may be indicative of impaired neuronal health. We hope that these findings will contribute towards the ongoing efforts to establish the cell-derived models of neurodegenerative diseases that are needed to develop patient-specific treatments

Perfil da violência contra mulheres atendidas na Pousada de Maria Perfil de la violencia sufrida por mujeres atendidas en la Posada de María Profile of the violence committed against women assisted at Pousada de Maria lodging

Pesquisa exploratória, retrospectiva, realizada na Pousada de Maria, em Curitiba, em 2007. Teve como objetivo caracterizar o perfil da violência praticada contra mulheres residentes na Pousada de Maria, durante os anos de 1993 à 2007. Os dados foram obtidos através da análise de 886 fichas de registro das vítimas, transcritos para um instrumento construído para a pesquisa. As vítimas tinham idade entre 18 e 88 anos, baixa escolaridade, e sofreram violência física, psicológica, sexual e estrutural, principalmente pelos companheiros e pessoas conhecidas. Convivem com a violência para manter a união familiar, e rompem com ela na existência de programas sociais e abrigos. A violência é um fenômeno frequente entre mulheres solteiras, com ensino fundamental incompleto: 24,6% delas sofreram violência física, 24,15%, psicológica, 14,22%, violência estrutural. As solteiras, amasiadas e casadas devem ser inseridas como grupo de risco e objeto de atenção, pelos profissionais de saúde no planejamento de ações preventivas.<br>Investigación exploratoria retrospectiva, realizada en la Posada de María en Curitiba, Brasil, en el año 2007, con el fin de caracterizar el perfil de la violencia ejercida contra mujeres que residieron en dicha institución en el período comprendido entre 1993 a 2007. Los datos fueron obtenidos a través del análisis de 886 fichas de registro de las víctimas y transcriptos para un instrumento formulado para la investigación. Las víctimas tenían entre 18 y 88 años, bajo índice de escolaridad; fueron víctimas de violencia física, psicológica, sexual y estructural, inflingida principalmente por sus compañeros y personas conocidas. Convivieron con la violencia para mantener la unión familiar, se libraron de ella cuando tuvieron acceso a programas sociales y amparos. La violencia es un fenómeno frecuente entre mujeres solteras con enseñanza primaria incompleta, 24,6% de ellas sufrieron violencia física, 24,15% psicológica, 14,22% violencia estructural. Las mujeres solteras, en concubinato y casadas deben ser insertadas como grupo de riesgo y objeto de atención por parte de los profesionales de la salud, en la planificación de acciones preventivas.<br>This exploratory, retrospective study was performed at the Pousada de Maria lodging in Curitiba, Brazil in 2007, with the objective of characterizing the profile of the violence practiced against women staying at Pousada de Maria from 1993 to 2007. Data collection was performed by analyzing 886 records of the victims' registration and transcribed to an instrument formulated for the study. The victims were between 18 and 88 years old, with low education; they suffered physical, psychological, sexual and structural violence, mainly by their partners and acquaintances. They lived with violence to maintain their family union and decided to resolve the situation when they had access to social programs and shelters. Violence is a common phenomenon among single women with incomplete primary education; 24.6% suffered physical violence, 24.15% psychological, and 14.22% structural violence. Single women, whether in a common-law relationship or married, should be considered as an at-risk group and worthy subjects of attention by health professionals when planning preventive actions