Dietary supplementation of heat-treated Gracilaria and Ulva seaweeds enhanced acute hypoxia tolerance in gilthead sea bream (Sparus aurata)

Intensive aquaculture practices involve rearing fish at high densities. In these conditions, fish may be exposed to suboptimal dissolved O2 levels with an increased formation of reactive O2 species (ROS) in tissues. Seaweeds (SW) contain biologically active substances with efficient antioxidant capacities. This study evaluated the effects of dietary supplementation of heat-treated SW (5% Gracilaria vermiculophylla or 5% Ulva lactuca) on stress bioindicators in sea bream subjected to a hypoxic challenge. 168 fish (104.5 g average weight) were distributed in 24 tanks, in which eight tanks were fed one of three experimental diets for 34 days: (i) a control diet without SW supplementation, (ii) a control diet supplemented with Ulva, or (iii) a control diet with Gracilaria. Thereafter, fish from 12 tanks (n=4 tanks/dietary treatment) were subjected to 24 h hypoxia (1.3 mg O2 l-1) and subsequent recovery normoxia (8.6 mg O2 l-1). Hypoxic fish showed an increase in hematocrit values regardless of dietary treatment. Dietary modulation of the O2-carrying capacity was conspicuous during recovery, as fish fed SW supplemented diets displayed significantly higher haemoglobin concentration than fish fed the control diet. After the challenge, survival rates in both groups of fish fed SW were higher, which was consistent with a decrease in hepatic lipid peroxidation in these groups. Furthermore, the hepatic antioxidant enzyme activities were modulated differently by changes in environmental O2 condition, particularly in sea bream fed the Gracilaria diet. After being subjected to hypoxia, the gene expression of antioxidant enzymes and molecular chaperones in liver and heart were down regulated in sea bream fed SW diets. This study suggests that the antioxidant properties of heat-treated SW may have a protective role against oxidative stress. The nature of these compounds and possible mechanisms implied are currently being investigated.Fil: Magnoni, Leonardo Julián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. Universidad de Porto; PortugalFil: Martos Sitcha, Juan Antonio. Consejo Superior de Investigaciones Científicas; EspañaFil: Queiroz, Augusto. Universidad de Porto; PortugalFil: Calduch Giner, Josep Alvar. Consejo Superior de Investigaciones Científicas; EspañaFil: Magalhaes Gonçalves, Jose Fernando. Universidad de Porto; PortugalFil: Rocha, Cristina M.R.. Universidad de Porto; PortugalFil: Abreu, Helena T.. ALGAplus; PortugalFil: Schrama, Johan W.. Wageningen University; Países BajosFil: Ozorio, Rodrigo O.A.. Universidad de Porto; PortugalFil: Perez Sanchez, Jaume. Consejo Superior de Investigaciones Científicas; Españ

Towards the entropy of gravity time-dependent models via the Cardy-Verlinde formula

For models with several time-dependent components generalized entropies can be defined. This is shown for the Bianchi type IX model. We first derive the Cardy-Verlinde formula under the assumption that the first law of thermodynamics is valid. This leads to an explicit expression of the total entropy associated with this type of universes. Assuming the validity of the Cardy entropy formula, we obtain expressions for the corresponding Bekenstein, Bekenstein-Hawking and Hubble entropies. We discuss the validity of the Cardy-Verlinde formula and possible extensions of the outlined procedure to other time-dependent models.Comment: 13 page

Minimal Superstrings and Loop Gas Models

We reformulate the matrix models of minimal superstrings as loop gas models on random surfaces. In the continuum limit, this leads to the identification of minimal superstrings with certain bosonic string theories, to all orders in the genus expansion. RR vertex operators arise as operators in a Z_2 twisted sector of the matter CFT. We show how the loop gas model implements the sum over spin structures expected from the continuum RNS formulation. Open string boundary conditions are also more transparent in this language.Comment: 36 pages, 3 figure

Spectral Flow in AdS(3)/CFT(2)

We study the spectral flowed sectors of the H3 WZW model in the context of the holographic duality between type IIB string theory in AdS(3)x S^3 x T^4 with NSNS flux and the symmetric product orbifold of T^4. We construct explicitly the physical vertex operators in the flowed sectors that belong to short representations of the superalgebra, thus completing the bulk-to-boundary dictionary for 1/2 BPS states. We perform a partial calculation of the string three-point functions of these operators. A complete calculation would require the three-point couplings of non-extremal flowed operators in the H3 WZW model, which are at present unavailable. In the unflowed sector, perfect agreement has recently been found between the bulk and boundary three-point functions of 1/2 BPS operators. Assuming that this agreement persists in the flowed sectors, we determine certain unknown three-point couplings in the H3 WZW model in terms of three-point couplings of affine descendants in the SU(2) WZW model.Comment: 50 pages, 2 figure

Solving Open String Field Theory with Special Projectors

Schnabl recently found an analytic expression for the string field tachyon condensate using a gauge condition adapted to the conformal frame of the sliver projector. We propose that this construction is more general. The sliver is an example of a special projector, a projector such that the Virasoro operator \L_0 and its BPZ adjoint \L*_0 obey the algebra [\L_0, \L*_0] = s (\L_0 + \L*_0), with s a positive real constant. All special projectors provide abelian subalgebras of string fields, closed under both the *-product and the action of \L_0. This structure guarantees exact solvability of a ghost number zero string field equation. We recast this infinite recursive set of equations as an ordinary differential equation that is easily solved. The classification of special projectors is reduced to a version of the Riemann-Hilbert problem, with piecewise constant data on the boundary of a disk.Comment: 64 pages, 6 figure

Star Algebra Projectors

Surface states are open string field configurations which arise from Riemann surfaces with a boundary and form a subalgebra of the star algebra. We find that a general class of star algebra projectors arise from surface states where the open string midpoint reaches the boundary of the surface. The projector property of the state and the split nature of its wave-functional arise because of a nontrivial feature of conformal maps of nearly degenerate surfaces. Moreover, all such projectors are invariant under constant and opposite translations of their half-strings. We show that the half-string states associated to these projectors are themselves surface states. In addition to the sliver, we identify other interesting projectors. These include a butterfly state, which is the tensor product of half-string vacua, and a nothing state, where the Riemann surface collapses.Comment: 65 pages, 23 figures, LaTe

Dynamical noncommutativity and Noether theorem in twisted phi^*4 theory

A \star-product is defined via a set of commuting vector fields X_a = e_a^\mu (x) \partial_\mu, and used in a phi^*4 theory coupled to the e_a^\mu (x) fields. The \star-product is dynamical, and the vacuum solution phi =0, e_a^\mu (x)=delta_a^\mu reproduces the usual Moyal product. The action is invariant under rigid translations and Lorentz rotations, and the conserved energy-momentum and angular momentum tensors are explicitly derived.Comment: 15 pages LaTeX, minor typos, added reference

Experimental String Field Theory

We develop efficient algorithms for level-truncation computations in open bosonic string field theory. We determine the classical action in the universal subspace to level (18,54) and apply this knowledge to numerical evaluations of the tachyon condensate string field. We obtain two main sets of results. First, we directly compute the solutions up to level L=18 by extremizing the level-truncated action. Second, we obtain predictions for the solutions for L > 18 from an extrapolation to higher levels of the functional form of the tachyon effective action. We find that the energy of the stable vacuum overshoots -1 (in units of the brane tension) at L=14, reaches a minimum E_min = -1.00063 at L ~ 28 and approaches with spectacular accuracy the predicted answer of -1 as L -> infinity. Our data are entirely consistent with the recent perturbative analysis of Taylor and strongly support the idea that level-truncation is a convergent approximation scheme. We also check systematically that our numerical solution, which obeys the Siegel gauge condition, actually satisfies the full gauge-invariant equations of motion. Finally we investigate the presence of analytic patterns in the coefficients of the tachyon string field, which we are able to reliably estimate in the L -> infinity limit.Comment: 37 pages, 6 figure

A paradigm of open/closed duality: Liouville D-branes and the Kontsevich model

We argue that topological matrix models (matrix models of the Kontsevich type) are examples of exact open/closed duality. The duality works at finite N and for generic `t Hooft couplings. We consider in detail the paradigm of the Kontsevich model for two-dimensional topological gravity. We demonstrate that the Kontsevich model arises by topological localization of cubic open string field theory on N stable branes. Our analysis is based on standard worldsheet methods in the context of non-critical bosonic string theory. The stable branes have Neumann (FZZT) boundary conditions in the Liouville direction. Several generalizations are possible.Comment: v2: References added; a new section with generalization to non-zero bulk cosmological constant; expanded discussion on topological localization; added some comment