Çocukluk çağı akut lösemileri kemik iliği blastik hücrelerinde vasküler endotelyal büyüme faktörü mrna düzeyi

TEZ4711Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2003.Kaynakça (s. 56-49) var.vii, 59 s. ; 30 cm.

Çocukluk çağı akut lösemilerinde flt3 (fms-like tyrosine kinase 3) mutasyonları

TEZ7022Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2008.Kaynakça (s.50-60) var.viii, 61 s. : res. ; 29 cm.Purpose: In this study it is aimed to investigate the presence of mutations of FLT3 receptor which is related with cellular surveillance, differentiation and proliferation pathways, and whether its presence affects prognosis and other clinical parameters in childhood leukemias. Matherial and Methods: Fifty three patients diagnosed as ALL and sixteen patients diagnosed as AML by cytomorphological, immuno histochemical and immuno flow-cytometric methods were included in this study. Results: FLT3/TKD mutation distribution in ALL and AML groups is as follows; only one patient in ALL group and 4 patients in AML group were detected. In ALL group the patient having mutation is 8 years old boy, in pre-B group ALL-L1, alive and also in remission. In the patients with mutation of AML group: one have relapsed disease and totally 3 of them deceased including relapsed patient, but there is no difference of mortality or morbidity between FLT3/TKD mutation carrying and others in AML patients statistically (p>0.05).Amac: Bu calısmada cocukluk cağı akut losemilerinde hucre yasamı, farklanma ve coğalması ile ilgili yollarla bağlantılı bir reseptor olan FLT3'un (FMS-Like Tyrosin Kinase) mutasyonlarının losemi hastalarında varlığı ve bu mutasyonların prognoz ve diğer klinik tablo ile iliskilerinin arastırılması planlandı. Materyal Metod: Calısmaya sitomorfolojik, immunohistokimyasal ve immun akımsitometrik metodlar ile ALL tanısı alan 53 hasta ile AML tanısı alan 16 cocuk hasta dahil edildi. Bulgular: ALL ve AML tanılı hasta gruplarında saptanan FLT3/TKD mutasyon dağılımı; ALL grubunda 1 hasta (% 2) ve AML grubunda 4 hasta (% 25) seklindeydi. Mutasyon saptanan ALL hastası 8 yasında erkek hasta FAB sınıflamasına gore ALL-L1 idi. mmunfenotipleme ile pre-B grubunda olan hasta risk grubu olarak SRG'ye dahil olmustu. Hasta halen hayatta ve remisyondaydı. AML grubunda FLT3/TKD mutasyonu tasıyan hastalar icinde bir hasta relaps olmustu, ancak relaps olan hasta ile birlikte 4 hastadan ucu kaybedilmisti. Buna rağmen yapılan istatistiksel incelemelerle mutasyon tasıyan AML hastaları ile tasımayan hastalar arasında mortalite ve morbidite acısından anlamlı bir fark saptanamadı (p>0,05).Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No

Pseudotumor cerebri, after the withdrowal of steroid treatment

Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen.Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen

Pseudotumor cerebri, after the withdrowal of steroid treatment

Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen.Pseudotumor cerebri or benign idiopathic intracranial hypertension is a disease characterized by increased intracranial pressure without any lesion with mass effect or hydrocephaly. In etiology beside several factors, we want to present a case with pseudotumor cerebri after steroid withdrawal because its rarely seen

Type 1 diabetes mellitus together with Lennox-gastaut syndrome: A case report

Tip 1 Diabetes Mellitus (DM), çocukluk çağında en sık görülen otoimmün özellik gösteren endokrin metabolik bir hastalıktır. Lennox-Gastaut Sendromu (LGS) refrakter epilepsi, tipik EEG bulgusu ve mental retardasyonla seyreden çocukluk çağının epileptik sendromlarmdandır. Burada son 3-4 aydır sabah kasılmaları, gün içinde görülen aniden başın öne doğru düşmesi ve ani sıçramaları olan EEG'si LGS ile uyumlu bulunan 3 yıldır Tip 1 diabet melütus tanısı ile izlenen 6 yaşındaki erkek çocuğu takdim edildi. Tip 1 diabetin patogenezinde otoimmünitenin rol oynaması, patogenezi tam açıklığa kavuşmasa da hastamızda LGS'nun Tip 1 diabet mellitus ile beraber olması ve verilen IVIG tedavisi ile nöbetlerinde anlamlı derecede azalma olması bu iki hastalığın patogenezinde benzer otoimmün mekanizmaların rolü olabileceğini düşündürmektedir. Konu ile ilgili yapılacak geniş kapsamlı çalışmaların, LGS'nun patogenezinin anlaşılmasında katkıda bulunacağına inanılmaktadır.Type 1 Diabetes Mellitus (DM) is the most common autoimmune endocrine and metabolic disease of childhood. Lennox-Gastaut Syndrome (LGS)is a chidhood epileptic syndrome characterized by refractery epilepsy, typical EEG findings and mental retardation. Here we present a six years old male with Type 1 DM who was admitted with complaints of sudden jerks with falling of head and morning convulsions in the past 3-4 months. The patogenesis of LGS is not understood yet and a diagnosis of LSG was made based on clinical and electroencephalographic findings. We know that autoimmunity plays role in the pathogenesis of Type 1 DM and the patient benefited significantly from an IVIG treatment. As a result this case suggested that an autoimmun disorder in the pathogenesis of LGS as in type 1 DM

A Pediatric Case of Post Traumatic Pulmonary Thromboembolism

Düşme sonrası sol alt ekstremite lateralinde yumuşak doku hasarı meydana gelen 10 yaşındaki erkek hasta, iki gün sonra gelişen yan ağrısı, göğüs ağrısı, solunum sıkıntısı ve ateş yakınmasıyla acil servise başvurdu. Yapılan fizik muayene, laboratuvar, Doppler ultrasonografi ve bilgisayarlı tomografi incelemeleri sonucu derin ven trombozu ve pulmoner tromboemboli tanısı kondu. Hastaya 6 saatlik doku plazminojen aktivatörü infüzyonu başlandı, daha sonra damar içi fraksiyone olmayan düşük molekül ağırlıklı heparin tedavisi verildi. Takibinde solunum sıkıntısı gerileyen hasta servise devredildi. Travma geçiren çocuklarda, çocukluk çağında oldukça nadir görülen fakat mortalitesi yüksek olan derin ven trombozu ve pulmoner tromboemboli gelişimi açısından dikkat edilmelidir.A 10-year-old male patient with a fall-related soft tissue injury of the lateral lower left extremity was admitted to the emergency room with the complaints of flank pain, chest pain, respiratory distress and fever developing two days later. The patient was diagnosed with deep vein thrombosis and pulmonary embolism after physical examination, findings of laboratory tests, Doppler ultrasonography and computed tomography. The treatment was initiated with the infusion of tissue plasminogen activator for 6 hours, and continued with intravenous unfractionated low-molecular-weight heparin. After the respiratory distress was improved, the patient was transferred to the pediatric hematology ward. Care should be taken in these quite rare, yet highly fatal conditions known as deep vein thrombosis and pulmonary embolism in traumatized children

A Pediatric Case of Post Traumatic Pulmonary Thromboembolism

A 10-year-old male patient with a fall-related soft tissue injury of the lateral lower left extremity was admitted to the emergency room with the complaints of flank pain, chest pain, respiratory distress and fever developing two days later. The patient was diagnosed with deep vein thrombosis and pulmonary embolism after physical examination, findings of laboratory tests, Doppler ultrasonography and computed tomography. The treatment was initiated with the infusion of tissue plasminogen activator for 6 hours, and continued with intravenous unfractionated low-molecular-weight heparin. After the respiratory distress was improved, the patient was transferred to the pediatric hematology ward. Care should be taken in these quite rare, yet highly fatal conditions known as deep vein thrombosis and pulmonary embolism in traumatized children

Comparison Of Pro-BNP Levels And Myocardial Performance Index Before And After Iron Treatment In Children With Congenital Cyanotic Heart Disease With Iron Deficiency Anemia

Introduction: Our aim was to compare NT-proBNP levels and cardiac functions after iron therapy in children with congenital cyanotic heart disease who had iron deficiency anemia.Materials and Methods: We included 40 children with pre-established cyanotic congenital heart disease and accompanying iron deficiency anemia, between the age of 6 months and 17 years, who were admitted to the outpatient clinic of Çukurova University Faculty of Medicine, Department of Pediatric Cardiology between September 2015 and March 2016. We recorded demographic data and performed following investigations: complete blood count, peripheral blood smear, reticulocyte count, measurement of serum iron levels, total iron-binding capacity, ferritin levels, transferrin saturation and NT-proBNP levels, and echocardiographic examination.Results: There was a statistically significant increase in following laboratory parameters after iron therapy: hemoglobin, hematocrit, MCV, MCHC, serum iron and ferritin, transferrin saturation and oxygen saturation. During the follow-up period, RDW and NT-proBNP levels were significantly decreased. In left ventricular tissue doppler; there was a significant difference in MPI measurements before and after treatment. There was no significant difference in other echocardiography findings. Conclusion: Iron therapy has improved cardiac functions in children with cyanotic congenital heart disease, and NT-proBNP levels can be used to evaluate the efficacy of treatment in the follow-up period