10 research outputs found
Criteria for the use of omics-based predictors in clinical trials: Explanation and elaboration
- Author
- A Beasley-Green
- A Dupuy
- AA Alizadeh
- AC Janssens
- AE Gelfand
- AM Molinaro
- B Freidlin
- B Freidlin
- Barbara A Conley
- C Ambroise
- C Hans
- C Strand
- Center for Devices and Radiological Health
- CM Perou
- Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
- CR Kinsinger
- D Sargent
- DA Cairns
- David A Eberhard
- Deborah J Shuman
- DG Altman
- DL Tabb
- External RNA Controls Consortium
- F Sun
- FE Harrell
- G Dimeski
- G Kurban
- G Poste
- GM Clark
- H Ishwaran
- HM Moore
- J Brettschneider
- J Brettschneider
- J Fan
- J Subramanian
- JA Sparano
- JA Wilson
- JA Zujewski
- James H Doroshow
- James V Tricoli
- JC Marioni
- JD Thorpe
- Jeremy MG Taylor
- JF Pierson-Perry
- Jill P Mesirov
- JL Hackett
- JM Perkel
- JMG Taylor
- JP Mesirov
- JPA Ioannidis
- JS Krouwer
- JS Parker
- JT Leek
- K Owzar
- Kelly Y Kim
- KGM Moons
- KGM Moons
- KK Dobbin
- KK Dobbin
- L Breiman
- L Buchen
- L Lusa
- L Shi
- L Shi
- LA Habel
- LC Jiang
- Lisa M McShane
- LM McShane
- LM McShane
- LM McShane
- LM McShane
- LW Clark
- M Bantscheff
- M McIntosh
- M Srinivasan
- Margaret M Cavenagh
- Mei-Yin C Polley
- MH Greene
- MH Zweig
- MN McCall
- MS Pepe
- Office of Biorepositories and Biospecimen Research
- P Mickey Williams
- PA Rudnick
- PM Bossuyt
- PM Bossuyt
- R Apweiler
- R Simon
- RA Irizarry
- RA Irizarry
- Richard M Simon
- RL Schilsky
- RM Simon
- S Dudoit
- S Katz
- S Paik
- T Hastie
- T Sorlie
- Tracy G Lively
- US Food and Drug Administration
- US Food and Drug Administration
- US Food and Drug Administration
- V Espina
- William L Bigbee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
High-throughput 'omics' technologies that generate molecular profiles for biospecimens have been extensively used in preclinical studies to reveal molecular subtypes and elucidate the biological mechanisms of disease, and in retrospective studies on clinical specimens to develop mathematical models to predict clinical endpoints. Nevertheless, the translation of these technologies into clinical tests that are useful for guiding management decisions for patients has been relatively slow. It can be difficult to determine when the body of evidence for an omics-based test is sufficiently comprehensive and reliable to support claims that it is ready for clinical use, or even that it is ready for definitive evaluation in a clinical trial in which it may be used to direct patient therapy. Reasons for this difficulty include the exploratory and retrospective nature of many of these studies, the complexity of these assays and their application to clinical specimens, and the many potential pitfalls inherent in the development of mathematical predictor models from the very high-dimensional data generated by these omics technologies. Here we present a checklist of criteria to consider when evaluating the body of evidence supporting the clinical use of a predictor to guide patient therapy. Included are issues pertaining to specimen and assay requirements, the soundness of the process for developing predictor models, expectations regarding clinical study design and conduct, and attention to regulatory, ethical, and legal issues. The proposed checklist should serve as a useful guide to investigators preparing proposals for studies involving the use of omics-based tests. The US National Cancer Institute plans to refer to these guidelines for review of proposals for studies involving omics tests, and it is hoped that other sponsors will adopt the checklist as well. © 2013 McShane et al.; licensee BioMed Central Ltd
On the Langevin equation with variable friction
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dynamical selection of Nash equilibria using reinforcement learning: Emergence of heterogeneous mixed equilibria
- Author
- A Alorić
- A Chakraborti
- A Madhavan
- AF Daughety
- Alejandro Raul Hernandez Montoya
- C Camerer
- C Chiarella
- C Daskalakis
- D Fudenberg
- D Schmeidler
- DK Gode
- E Samanidou
- F Bouchet
- G Bunin
- G Carmona
- G Ellison
- GW Brown
- H Josef
- H Risken
- HA Kramers
- IA Kash
- JM Lasry
- K Cai
- KP Rath
- LC CorchĂłn
- LMB Cabral
- M Heymann
- MI Freidlin
- N Cesa-Bianchi
- Peter Sollich
- R Golman
- Robin Nicole
- RS Sutton
- T Galla
- TC Schelling
- Y Sato
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Strengths Based Coaching—A Positive Psychology Intervention
- Author
- A Furnham
- A Markström
- A McDowall
- A Weick
- AL Duckworth
- AL Duckworth
- AM Naify
- B McLean
- B Roche
- C Fluckiger
- C Kaufman
- C Peterson
- C Peterson
- C Tansley
- CAPP
- D MacKie
- D MacKie
- D Welch
- E Michaels
- EJ Smith
- EN Smith
- F Elston
- H Goldstein
- H Littman-Ovadia
- J Brook
- J Brook
- J Burke
- J Passmore
- J Passmore
- J Passmore
- J Passmore
- J Passmore
- JS Cheavens
- LC Hone
- M Lombardo
- M Mongrain
- MEP Seligman
- P Dubreuil
- P Freidlin
- R Biswas-Diener
- R Biswas-Diener
- R Biswas-Diener
- R Hogan
- RE McGrath
- RE McGrath
- RE McGrath
- René T. Proyer
- RM Niemiec
- Ryan M. Niemiec
- S Crabb
- ST Dennison
- T Rust
- TB Kashdan
- W Madden
- YJ Wong
- Z Subarsky
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Strengths approaches have grow in popularity over the past decade, with
a profileration of writing, models and questionnaires used for strengths assessment
and in coaching. These questionnaires include including VIA, Strengthscope and
StrengthsFinder and Strengths Profile. The questionnaires have become a popular
intervention for consultants, HR professionals and executive coaches for adding both
personal development and coaching, to assisting with recruitment and selection. We
will briefly review in the first section of this chapter three popular questionnaires,
considering their development and constructs. In the second section we will explore
positive psychology coaching as an intervention using questionnaires and strengths
cards, before reviewing the research evidence and opportunities for future research
Clinical trials in the age of personalized medicine
- Author
- A Dowlati
- A Stone
- AD Barker
- Alberto Cambrosio
- AW Millar
- B Chabner
- B Freidlin
- BS Craft
- C Tournoux-Facon
- CM Booth
- CP Adams
- D Lacombe
- DM Dilts
- EA Eisenhauer
- EL Korn
- HK Gan
- HL Goulart
- I Kola
- Institute of Medicine
- Institute of Medicine
- Institute of Medicine
- J Arrowsmith
- JA DiMasi
- JE Dancey
- JF Scoggins
- JJ Lee
- JJ Lee
- JPE Karlberg
- L Mariani
- L Seymour
- LC Michaelis
- M Gutierrez
- M Miller
- ME Gutierrez
- MJ Ratain
- MJ Ratain
- MJ Ratain
- N Kohli-Laven
- P Keating
- P Therasse
- Peter Keating
- PM LoRusso
- R Leff
- R Schilsky
- R Simon
- RH El-Maraghi
- RH Glassman
- S Hunsberger
- S Kummar
- S Postel-Vinay
- S Sleijfer
- SE Taube
- SP Ivy
- T Burzykowski
- T Reynolds
- T Vidaurre
- TA Yap
- TS Mok
- WR Parulekar
- WT Robinson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration
- Author
- A Beasley-Green
- A Dupuy
- AA Alizadeh
- AC Janssens
- AE Gelfand
- AM Molinaro
- B Freidlin
- B Freidlin
- Barbara A Conley
- C Ambroise
- C Hans
- C Strand
- Center for Devices and Radiological Health
- CM Perou
- Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
- CR Kinsinger
- D Sargent
- DA Cairns
- David A Eberhard
- Deborah J Shuman
- DG Altman
- DL Tabb
- External RNA Controls Consortium
- F Sun
- FE Harrell
- G Dimeski
- G Kurban
- G Poste
- GM Clark
- H Ishwaran
- HM Moore
- J Brettschneider
- J Brettschneider
- J Fan
- J Subramanian
- JA Sparano
- JA Wilson
- JA Zujewski
- James H Doroshow
- James V Tricoli
- JC Marioni
- JD Thorpe
- Jeremy MG Taylor
- JF Pierson-Perry
- Jill P Mesirov
- JL Hackett
- JM Perkel
- JMG Taylor
- JP Mesirov
- JPA Ioannidis
- JS Krouwer
- JS Parker
- JT Leek
- K Owzar
- Kelly Y Kim
- KGM Moons
- KGM Moons
- KK Dobbin
- KK Dobbin
- L Breiman
- L Buchen
- L Lusa
- L Shi
- L Shi
- LA Habel
- LC Jiang
- Lisa M McShane
- LM McShane
- LM McShane
- LM McShane
- LM McShane
- LW Clark
- M Bantscheff
- M McIntosh
- M Srinivasan
- Margaret M Cavenagh
- Mei-Yin C Polley
- MH Greene
- MH Zweig
- MN McCall
- MS Pepe
- Office of Biorepositories and Biospecimen Research
- P Mickey Williams
- PA Rudnick
- PM Bossuyt
- PM Bossuyt
- R Apweiler
- R Simon
- RA Irizarry
- RA Irizarry
- Richard M Simon
- RL Schilsky
- RM Simon
- S Dudoit
- S Katz
- S Paik
- T Hastie
- T Sorlie
- Tracy G Lively
- US Food and Drug Administration
- US Food and Drug Administration
- US Food and Drug Administration
- V Espina
- William L Bigbee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Therapeutic Advances and Future Prospects in Progressive Forms of Multiple Sclerosis
- Author
- A Bot
- A Botas
- A Catania
- A Compston
- A Fassas
- A Fassas
- A Feinstein
- A Lutterotti
- A Petzold
- A Scalfari
- AA Vandenbark
- AA Vandenbark
- AA Vandenbark
- Afsaneh Shirani
- AJ Coles
- AJ Thompson
- AL Davies
- Anon
- Anon
- Anon
- Anon
- AP Robinson
- AS Novgorodov
- B Freidlin
- B Freidlin
- B Soliven
- B Tabarki
- BC Cheah
- BG Arnason
- C Bartels
- C Brana
- C Confavreux
- C Malmestrom
- CE Stafstrom
- CM Lim
- D Morsali
- D Ontaneda
- D Ontaneda
- D Pohlau
- D Ribatti
- Darin T. Okuda
- DH Mahad
- DH Miller
- E Fox
- F Barkhof
- F Sedel
- F Sedel
- F Zhang
- FD Lublin
- G Civenni
- G Pihl-Jensen
- GH Marracci
- GP Rice
- H Ehrenreich
- H Lassmann
- H Levy
- H Panitch
- H Phan
- H Wiendl
- HM Said
- HM Vesterinen
- J Chataway
- J Chataway
- J Feng
- J Kuhle
- J Romme Christensen
- J Zajicek
- JA Black
- JA Kairalla
- JH Noseworthy
- JH Noseworthy
- JS Wolinsky
- K Hawker
- K Schmitz
- K Selmaj
- LC Gibson
- M Bonnan
- M Brines
- M Caruana
- M Kolappan
- M Radaelli
- M White
- MA Friese
- MC Kowarik
- MM Paz Soldan
- MN Alme
- MS Freedman
- MS Weber
- MT Fischer
- N Hellings
- O Aktas
- O Andersen
- O Neuhaus
- O Stuve
- O Stuve
- Olaf StĂĽve
- OR Hommes
- P Browne
- P Connick
- P Dubreuil
- P Fitzgerald
- P Sarno De
- P Vermersch
- PJ Most van der
- PK Coyle
- PS Rommer
- PT Ozand
- Q Sun
- R Kapoor
- R Magliozzi
- RA Nash
- RA Nash
- RA Rudick
- RC Girvan
- RE Raftopoulos
- RJ Fox
- RM Ransohoff
- RS Jope
- RW Beck
- S Hametner
- S Jaber
- S Mi
- S Salinthone
- S Vergo
- S Zhornitsky
- S Zhornitsky
- SM Fiebiger
- SR Choi
- T Mizuno
- TC Theoharides
- V Yadav
- VK Harris
- VV Brinar
- VW Yong
- W Li
- Y Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Die Mischkontakte
- Author
- A Adkins
- A Agliardi
- A Couper
- A Couper
- A Eucken
- A Eucken
- A Eucken
- A Eucken
- A Eucken
- A Eucken
- A Grenall
- A Grenall
- A Grenall
- A Grenall
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Juliard
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittasch
- A Mittascii
- A Pongratz
- A Schneider
- A Scipioni
- A Scipioni
- A Taylor
- A Thomas
- AA Bag
- AA Bag
- AA Bag
- AA Bag
- AA Balandin
- AA Balandin
- AA Balandin
- AA Balandin
- AF Plate
- AF Plate
- AF Plate
- AK Brewer
- AM Rubinstein
- AM Rubinstein
- AO White
- AT Larson
- AT Larson
- AT Williamsson
- AV Grosse
- AV Grosse
- AV Grosse
- AV Grosse
- AW Frost
- AW Gauger
- AY Zvorykin
- B Berk
- B Foresti
- B Kubota
- B Kubota
- B Neumann
- B Neumann
- B Svensson
- B Yamaguti
- Bakelite Corp. Canad. Pat. 323665
- BB Corson
- BB Corson
- BEV Boven
- BN Dolgow
- BN Dolgow
- BN Dolgow
- BN Dolgow
- BN Dolgow
- BS Greensfelder
- BS Greensfelder
- BS Srikantan
- C Herbo
- C Herbo
- C Herbo
- C Herbo
- C Herbo
- C Herbo
- C Kelber
- C Paal
- C Paal
- C Schuster
- CF Fryling
- CF Powell
- CH Kunsman
- CH Riess
- CH Riesz
- CI Engelder
- CL Levesque
- CL Thomas
- CL Thomas
- CL Thomas
- CW Lenth
- DA Dowden
- DA Dowden
- DA Possopechow
- DA Possopechow
- DA Possopechow
- DJ Salley
- DM Newitt
- DN Wasskewitsch
- DR Levering
- DR Levering
- E Audibert
- E Decarriére
- E Keunecke
- E Lieber
- E Mariani
- E Mariani
- E Mariani
- E Mariani
- E Vogt
- E Vogt
- E Wicke
- E Wicke
- E Yamaguti
- EB Maxted
- EB Maxted
- EC Huges
- EC Lory
- EC Lory
- EC Withe
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EF Armstrong
- EFG Herington
- EH Taylor
- EK Rideal
- F Benton
- F Fischer
- F Fischer
- F Fischer
- F Fischer
- F Fischer
- F Fischer
- F Fischer
- F Fischer
- F Lihl
- F Lihl
- F Schuster
- FA Griffith
- FE Fischer
- FE Smith
- FE Smith
- FET Kingman
- FET Kingman
- FF Volkenstein
- FH Gayer
- FLW McKim
- G Bodamer
- G Bodamer
- G Broughton
- G Calingaert
- G Calingaert
- G Calingaert
- G Cohn
- G Dupont
- G Dupont
- G Lunde
- G Lunde
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Natta
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
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- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
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- G Rienäcker
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- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
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- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker
- G Rienäcker von
- G Tammann
- G Tammann
- G Wagner
- G Wagner
- G Wagner
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
- G-M Schwab
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- G-M Schwab
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- G-M Schwab
- G-M Schwab
- G-M Schwab
- GA Mills
- GA Mills
- GA Mills
- GB Simek
- GD Liubarski
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig
- GF HĂĽttig von
- GG Thomas
- GG Urazow
- GI Finch
- GI Finch
- GM Klein
- GM Schwab
- GM Zhabrova
- GN Meslianskii
- GP Baxter
- GR Levi
- GR Levi
- GR Levi
- GR Levi
- GR Levi
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Adkins
- H Brintzinger
- H BrĂĽckner
- H BrĂĽckner
- H BrĂĽckner
- H Dohse
- H Fehrer
- H Heinemann
- H Huber
- H Inone
- H Inone
- H Inone
- H Jenny
- H Morris
- H Morris
- H Morris
- H Morris
- H Morris
- H Pichler
- H Remy
- H Remy
- H Sadek
- H Sinozaki
- HA Doyal
- HA Smith
- HA Smith
- HA Smith
- HA Smith
- HJ Seemann
- HJ Seemann
- HP Kaufmann
- HS Black
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HS Taylor
- HY Chiang
- I Konaka
- I Konata
- I Rabes
- I Shapiro
- IB Rapoport
- IB Rapoport
- IB Rapoport
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
- IJ Adadurow
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- J Anderson
- J Burgin
- J BĂ©nard
- J BĂ©nard
- J Eckell
- J Eckell
- J Eckell
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- J Eckell
- J Gavat
- J Howard
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- J Liebig
- J Longuet
- J Longuet-Escard
- J Pease
- J Pease
- J Pease
- J Pirie
- J Sauer
- J Turkevich
- J Turkevich
- JA Almquist
- JA Almquist
- JA Almquist
- JA Christiansen
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Hedvall
- JA Patterson
- JB Senderens
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JC Ghosh
- JCW Frazer
- JCW Frazer
- JCW Frazer
- JCW Frazer
- JD Strompe
- JE Lennard Jones
- JF Keggin
- JF Levis
- JF Woodman
- JF Woodman
- JF Woodman
- JF Woodman
- JH Long
- JH Long
- JI Ssiltschenko
- JJ Lange de
- JM Mavity
- JM Mavity
- JM Slobodin
- JM Slobodin
- JN Pattison
- JR Deimann
- JR Owen
- JR Reasenberg
- JS Salkind
- JW Döbereiner
- JW Holmes
- K Butkowski
- K Butkowsky
- K Folkers
- K Folkers
- K Ishimura
- K Ishimura
- K Kino
- K Kobayasi
- K Ktno
- K Peters
- K Starke
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- K Yoshikawa
- KA Kobe
- KK Kearby
- KK Kearby
- KM Chakravarty
- KM Chakravarty
- KN Iwanow
- KN Iwanow
- KS Love
- KS Lowa
- L Fenconau
- L Fenconau
- L Guchmann
- L Gurwitsch
- L Gurwitsch
- L Kahlenberg
- L Lutten
- L Passerini
- L Passerini
- L Passerini
- L Passerini
- L Passerini
- L Passerini
- L Passerini
- L Passerini
- L Paul
- L Ubbelohde
- L. Kahlenberg
- LC Freidlin
- LC Freidlin
- LF Martin
- LL Gershbein
- LN Katzaurow
- LN Katzaurow
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- O Block
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- VS Ssadikow
- W Dominik
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- W Ipatieff
- W Ipatieff
- W Ipatieff
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- W Ipatieff
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- W Ipatieff
- W Jander
- W Jander
- W Jander
- W Jander
- W Jander
- W Jander
- W Jander von
- W Krauss
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- W Normann
- W Riddel
- W Riddel
- W Rogers Jr.
- W Wassilyew
- WA Lazier
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Plotnikow
- WA Roiter
- WE Garner
- WE Garner
- WF Polosow
- WG Burgers
- WH Carmody
- WH Carothers
- WH Lockwood
- WH Lockwood
- WJ Mattox
- WJ Mattox
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- Z Csuros
- Z Csuros
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1957
- Field of study
Platinum-Group Metals, Alloys and Compounds in Catalysis
- Author
- A Borodzinski
- A Borodzinski
- A Farkas
- A Frackiewicz
- A Furst
- A Harriman
- A Nakamura
- A Nidola
- A Ofner
- A Onopchenko
- A Prince
- A Prince
- A Sieverts
- A Wheeler
- AA Grinberg
- AA Grinberg
- AA Grinberg
- AA Siddiqi
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Stiles
- ACL Su
- AD Ketley
- AD Ketley
- AD Semenova
- AD Semenova
- AD Semenova
- AD Semenova
- AD Westland
- ADF Toy
- AE Heywood
- AE Rea
- AE Shilov
- AER Budd
- AF Diwell
- AF Diwell
- AF Diwell
- AF Wells
- AF Wells
- AG Burden
- AG Knapton
- AG Oblad
- AH Janowicz
- AJ Appleby
- AJ Birch
- AJ Bird
- AJ Bird
- AJ Bird
- AJ Canale
- AJ Chalk
- AJ Haagen-Smit
- AJB Robertson
- AJB Robertson
- AK Holliday
- AK Holliday
- AL Wilds
- AM Feltham
- AM Taber
- AM Taber
- AM Taber
- AM Taber
- AM Taber
- AM Taber
- AN Mal’tsev
- AN Mal’tsev
- AN Mal’tsev
- AN Mal’tsev
- AN Mal’tsev
- AN Mal’tsev
- AR Miedema
- AR Miedema
- AS Al-Ammor
- AS Arifulin
- AS Berezhnoi
- AT Gwathmey
- AU Rahman
- AV Shashkina
- AV Shashkina
- AW Holmes
- AW Holmes
- AW Johnson
- AW Maverick
- AW Middleton
- B Aronsson
- B Aronsson
- B Aronsson
- B Aronsson
- B Beden
- B Berkman
- B Christensen
- B Christensen
- B Cornils
- B Delmon
- B Delmon
- B Delmon
- B Delmon
- B Delmon
- B Delmon
- B Delmon
- B Gorewit
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- BL Moldavskii
- BL Tarmy
- BR James
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- BYK Pan
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- C Barnett
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- CA Brown
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- CW Keenan
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- CY Tay
- D Bergner
- D Cahen
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- D Danly
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- D McDonald
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- DA Denton
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- E Bayer
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- F Ansinger
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- GK Boreskov
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- Gmelin Handbook of Inorganic Chemistry
- Gmelin Handbook of Inorganic Chemistry
- GS Ospanova
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- GV Samsonov
- GW Parshall
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- H Arai
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- Y Berthier
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
Evolocumab and clinical outcomes in patients with cardiovascular disease
- Author
- Abelson M
- Aboufakher R
- Abrahamsen Te
- Accini Mendoza Jl
- Acheatel R
- Ackermann D
- Adamkova V
- Adams M
- Adlam D
- Aggarwal R
- Aggarwal S
- Ahsan A
- Ainsworth P
- Airody Govinda R
- Akai A
- Ako J
- Al-Bahrani A
- Al-Joundi T
- Aldegather J
- Aldrete Velasco Ja
- Alfieri A
- Alt I
- Alzohaili O
- Amerena J
- Amin J
- Amoedo R
- Amuchastegui M
- Anderson T
- Andreka P
- Andreotti F
- Angoulvant D
- Ansell B
- Antalik L
- Antkowiak-Piatyszek K
- Appel K
- Arakawa T
- Arana Londoño C
- Ardissino D
- Ardito Wr
- Arkhipov M
- Arsenescu-Georgescu C
- Asamoah N
- Ascaso Gimilio Jf
- Atar S
- Atassi K
- Athyros V
- Auerbach E
- Awtry E
- Baass A
- Badariene J
- Badat A
- Badila E
- Bae J
- Baigent C
- Bain S
- Baird I
- Baker J
- Balbay Y
- Baldari D
- Ballantyne C
- Bammert A
- Banach M
- Bandh S
- Banerjee S
- Banik M
- Banikova A
- Barbarash O
- Barcinas R
- Barnum O
- Barroso de Souza Wk
- Bart B
- Barton J
- Bata I
- Batalla E
- Bayat J
- Bazzoni Ruiz Ae
- Bednarkiewicz Z
- Beer Hj
- Begg A
- Beltrame J
- Bendermacher P
- Benton R
- Berger C
- Bergeron J
- Bergler-Klein J
- Berglund S
- Berlacher P
- Bernstein M
- Bertolet B
- Bertolim Precoma D
- Bhagwat R
- Bhargava R
- Bhushan R
- Biasucci Lm
- Bilianou H
- Blagden M
- Blaha V
- Blasko P
- Blicharski T
- Blignaut S
- Blokhin A
- Blumberg E
- Bodanese Lc
- Bokern M
- Bolshakova O
- Bonaca Mp
- Bonnet B
- Bosiljanoff P
- Boswijk D
- Botero Lopez R
- Bourhaial H
- Bousboulas S
- Brabec T
- Brezina B
- Bronnum-Schou J
- Brotanek J
- Broughton R
- Brown C
- Brown Wv
- Bubnova M
- Budoff M
- Burgess L
- Burianova H
- Burrough B
- Butler R
- Buysschaert I
- Bystryk L
- Capps N
- Cappuccio F
- Cardona Muñoz Eg
- Carhart R
- Cariou B
- Carr K
- Case C
- Castellanos Bueno R
- Catez E
- Caulfield M
- Cayla G
- Cech V
- Cepelak M
- Ceska R
- Cha J
- Chandra L
- Chapman K
- Charlier F
- Charng Mj
- Charvat J
- Chauhan A
- Cheek Hb
- Chehayeb R
- Chen J
- Chen X
- Chen Y
- Chenu P
- Cheung D
- Cho Y
- Choi D
- Chopra Vk
- Chorin E
- Christensen T
- Christofides E
- Cifkova R
- Civeira Murillo F
- Cizinsky S
- Clardy D
- Claxton E
- Clements B
- Cobos Jl
- Coching Rm
- Coetzer Tf
- Coisne D
- Collins J
- Colombo H
- Coman I
- Conejeros Kindel C
- Connolly D
- Constance C
- Contzen C
- Cordero Fort A
- Cornel Jh
- Coronel Arroyo Ja
- Cosmi F
- Cottin Y
- Cox N
- Crater T
- Crean P
- Croce K
- Cross D
- Crowley D
- Cruickshank K
- Cuadrado Ja
- Cui H
- Cui Y
- Cummings M
- Cuneo C
- Cunha Borges Jl
- Cure Cure Ca
- Cygler J
- Dabrowska M
- Dabrowski M
- Dahlén G
- Dai H
- Dan Ga
- Danias P
- Darius H
- Dauber I
- Dave K
- Davila W
- Davis Br
- Davis G
- Davis M
- Dawood S
- de Belder M
- De Caterina R
- De Ferrari Gm
- De Jong Dm
- De La Cruz A
- De la Peña Topete Gdj
- De los Rios Ibarra Mo
- De Meulemeester M
- De Nooijer C
- De Raedt H
- de Sa Cunha R
- De Souza J
- Dear H
- Deedwania Pc
- Delarche N
- Delgado E
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- Dobratz D
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- Dronov D
- du Toit M
- Du Y
- Duarte Barbosa Ec
- Dubaniewicz W
- Duchesne L
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- Dunbar R
- Durlach V
- Dutra O
- Duzenli M
- Dwivedi Sk
- Dyke C
- Dzupina A
- Earl J
- Eaton C
- Ebenbichler C
- Eberli F
- Ebrahim I
- Edes I
- Eglite R
- Egstrup K
- El Shahawy M
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- Elbl L
- Eliaschewitz Fg
- Elisaf M
- Ellery A
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- Erickson B
- Erng T
- Estepar Ra
- Ezhov Mv
- Fagan T
- Fairlie H
- Falck G
- Fan Kyy
- Farhat N
- Farris N
- Farshid A
- Fedele Francesco
- Fernandes Manenti Er
- Fernandez S
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- Finlayson J
- Fiore G
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- Fishbein G
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- Focil A
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- Garrahy P
- Gaudet D
- Gaunt R
- Gavish D
- Ge Z
- Geadah C
- Gelfand E
- Georgiev Bg
- Germar A
- Ghali J
- Gilpatrick M
- Giugliano G
- Giugliano Robert P.
- Glenny Ja
- Go A
- Go Y
- Goel A
- Goldenberg E
- Goloshchekin B
- Golovchenko O
- Gonnelli S
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- Gonzalez Juanatey Jr
- Gonzalez-Galvez G
- Goralski M
- Gordeev I
- Gorog D
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- Graham J
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- Gruberg L
- Grzegorzewski B
- Gu Y
- Gupta D
- Gupta M
- Gustiene O
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- Guzik T
- Gyrina O
- Habaluyas R
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- Hage Korban E
- Hajko E
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- Hall A
- Halperin F
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- Handelsman Y
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- Hanusch U
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- Hasin Y
- Hata Y
- Hatalova K
- Hatharasinghe R
- Haught Wh
- He Y
- Hearne S
- Heller S
- Henderson D
- Henein S
- Hengstenberg C
- Hennekens Ch
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- Herczeg B
- Herman L
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- Higashi Y
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- Hornyik A
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- Hosokawa S
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- Hovland A
- Hoye A
- Hrabar A
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- Hsia C
- Hsieh I
- Hsieh Y
- Huang C
- Huang H
- Huang W
- Huber K
- Huling R
- Hulinsky V
- Huynh T
- Hysing J
- Ibrahim H
- Iida H
- Ilkowski J
- Illescas Diaz Jj
- Im K
- Inage T
- Inoko M
- Isermann B
- Issa B
- Issa M
- Isserman S
- Iteld B
- Ivan P
- Iwade K
- Izar Mc
- Izumiya Y
- Iñiguez Romo A
- Jaafar F
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- Jacovides A
- Jain A
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- Jasinkevica I
- Jehle A
- Jelinek P
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- Jeong M
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- Jerabek O
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- Joshi A
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- Kanevsky E
- Kania G
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- Karen I
- Karpenko O
- Kashyap M
- Kassner U
- Kast P
- Katsuda Y
- Kawabata K
- Kawamitsu K
- Kawasaki T
- Kayikcioglu L
- Kazdera P
- Keech Anthony C.
- Keeling P
- Kellnerova I
- Kereiakes D
- Kerr Saraiva Jf
- Khalife K
- Khan A
- Khan B
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- Khanoyan P
- Khurana S
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- Knusel B
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- Koren M
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- Korzh O
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- Kosior D
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- Kothiwale V
- Kovar F
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- Kubica J
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- Kulkarni G
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- Kurtz Lisboa Hr
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- Landzberg J
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- Lekuona Goya I
- Lennerova J
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- Leon Gonzalez S
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- Linka A
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- Zamorano Gomez Jl
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- Zilahi Z
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- Ă–stergren J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab (2.1% vs. 1.6%). CONCLUSIONS In our trial, inhibition of PCSK9 with evolocumab on a background of statin therapy lowered LDL cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. These findings show that patients with atherosclerotic cardiovascular disease benefit from lowering of LDL cholesterol levels below current targets