The Use of Plasmapheresis in Treatment of Patients with Infertility, Peritoneal Endometriosis and Nat2 Gene Polymorphism

It is known that 30–40 % of patients with peritoneal endometriosis suffer from infertility. Half of the patients with endometriosis are identified point mutation in NAT2 – gene, which plays an important role in the acetylation of aromatic and heterocyclic amines, in the accumulation of endotoxins, activation of free radical oxidation, impaired microcirculation. These factors involve the use of methods of gemapheresis which have detoxification, the blood rheology corrective and immune corrective effects. The purpose of this study was to evaluate the efficacy of therapeutic plasma exchange in treatment of patients with peritoneal form of endometriosis, infertility and point mutations in the gene NAT2. The study included 140 patients with infertility, peritoneal form of endometriosis and point mutations in the gene NAT2. All patients are performed laparoscopy, coagulation foci of endometriosis. In the following 93 (66.4 %) patients were treated with a the course of therapeutic plasmapheresis using the apparatus «PCS-2» with the removal of 20–25 % the volume of circulating plasma with replacement plasma of crystalloid and colloid solutions. Before treatment were shown the signs of endotoxemia, activation of oxidative stress. After treatment with the use of plasmapheresis was revealed the significant reduction of endogenous intoxication parameters and oxidative stress. Also is noted the increase in the pregnancy rate, both independently and in IVF programs, especially during the first 3 months after treatment. The findings suggest that the efficiency of the proposed comprehensive treatment techniques (laparoscopy and subsequent course of therapeutic plasmapheresis) of patients with peritoneal endometriosis and infertility and with point mutations in the gene NAT2. The use of plasmapheresis is pathogenetically justified in patients of the studied group

Аdvantages and disadvantages of digitalization of liberal education

The relevance of the problem of digitalization of liberal education is caused, on the one hand by the reduction of classroom classes in the humanities (History, Cultural studies, Foreign language, etc.) in higher school and the demand for autonomous students training; оn the other hand there are advantages of digitalization in the global world, which can enrich and diversify traditional education. The article authors consider that this process has problem areas too. Research objectives are: to consider the means and properties of information educational technologies; to analyze the theoretical works about educational digitalization; to determine advantages and disadvantages of the digital technologies use in the learning process. The main research method is the analysis and synthesis of theoretical research, the presentation of provisions about the functional and motivational aspects of digital technologies; about the need for their use in the educational process at the University. The authors propose to study the historical heritage through information and communication technologies, to focus on notable phenomena of world history, to follow the students self-reflection, internal motivation for self-improvement of modern generation, the maximum realization of its potential and high-tech achievements. The empirical material was a long-term experience of teaching the humanities using information and communication technologies at Ogarev Mordovia State University and on postgraduate studies at Research Institute by the Government of the Republic of Mordovia. This article differs from the other researches by the universality of the scientific approach, by the conclusions novelty and schematic visualization of scientific results. The authors clearly presented the advantages of digital technologies, which include many different tools for autonomous learning and simplify the holding of the classes. Thus, it is advisable to use the digital technologies in the educational process

Анализ показателей рынка банковских карт России по различным признакам

Purpose of the study. The article presents the results of a study and analysis of the performance indexes of the Russian bank cards market on various grounds, because bank cards contribute to increasing the availability of financial services. Having a bank card allows you to carry out financial transactions anytime and anywhere and makes these transactions more convenient and transparent. The use of bank cards as a non-cash form of payment is not only convenient and practical, but also contributes to improving the economic situation in the country, expanding the availability of financial services and improving financial literacy.Materials and methods. As research tools, such methods were used as: analysis of the structure and dynamics of the main indexes, correlation and regression analysis, analysis of time series and forecasting, graphical and tabular methods for presenting research results.Results. The analysis carried out in relation to the issue of bank cards in Russia made it possible to establish the impact on the number of payment cards of two factors: the number of credit institutions and the average per capita income of the population (per month). The results obtained showed that an increase in the number of credit institutions leads to a reduction in the number of issued payment cards. In turn, with an increase in the average per capita monetary income of the population (per month), the number of payment cards increases. This suggests that a high level of income and good conditions for obtaining credit funds are an incentive to use payment cards. Bank cards are an integral part of the financial services market. The development of the bank card market has an impact on stimulating the country’s economic growth and improving the quality of life of the population. In modern conditions, banks are actively introducing electronic technologies and improving the use of bank cards by customers. The creation of convenient services and the introduction of new technologies make it possible to expand the possibilities of using bank cards for their holders.Цель исследования. В статье представлены результаты исследования и анализа показателей деятельности рынка банковских карт России по различным признакам, т.к. банковские карты способствуют повышению доступности финансовых услуг. Наличие банковской карты позволяет осуществлять финансовые операции в любое время и в любом месте и делает данные операции более удобными и прозрачными. использование банковских карт в качестве безналичной формы оплаты является не только удобным и практичным, но и способствует улучшению экономической ситуации в стране, расширению доступности финансовых услуг и повышению финансовой грамотности.Материалы и методы. В качестве исследовательского инструментария использованы такие методы как: анализ структуры и динамики основных показателей, корреляционно-регрессионный анализ, анализ временных рядов и прогнозирования, графические и табличные методы представления результатов исследования.Результаты. Проведенный анализ в отношении эмиссии банковских карт в России позволил установить влияние на количество платежных карт двух факторов: числа кредитных организаций и среднедушевых доходов населения (в месяц). Полученные результаты показали, что увеличение числа кредитных организаций приводит к сокращению количества выпущенных платежных карт. В свою очередь, при увеличении среднедушевых денежных доходов населения (в месяц) количество платежных карт увеличивается. Это говорит о том, что высокий уровень доходов и хорошие условия для получения кредитных средств являются стимулом для использования платежных карт. Банковские карты являются неотъемлемой частью рынка финансовых услуг. Развитие рынка банковских карт влияет на стимулирование экономического роста страны и повышение качества жизни населения. В современных условиях банки активно внедряют электронные технологии и совершенствуют использование клиентами банковских карт. Создание удобных сервисов и введение новых технологий позволяют расширить возможности использования банковских карт для их держателей

The Impact of COVID-19 on doctors well-being: Results of a web survey during the lockdown in Italy

OBJECTIVE: On March 12, 2020, the World Health Organization (WHO) declared the outbreak of a new Coronavirus disease (COVID-19), to be a pandemic. From the be- ginning, Italy (in particular the Northern re- gions) was the first large European country to be hit and one of the most affected coun- tries worldwide. This had a significant impact on the workload and psychological health of health workers. The aim of this web-based cross-sectional study is to assess the con- sequences of the COVID-19 pandemic on Ital- ian doctors’ well-being and psychological dis- tress, in respect of demographic and occu- pational characteristics, lifestyle and habits during the lockdown period.PATIENTS AND METHODS: We conducted a web-based cross-sectional survey based on Google® Forms to collect data. The participa- tion was available during the lockdown period that started in Italy on March 9, 2020 and it was voluntary and anonymous. The question- naire explored demographic and occupational variables, lifestyle and habits during the lock- down, perceived well-being and psychological distress. Multivariate logistic regression models were fitted. RESULTS: Our study reported the very alarm- ing psychological conditions of Italian doctors, especially among those who worked in the most affected regions, where a level of psychological distress of 93.8% and poor well-being of 58.9% were registered. These percentages were even higher in the case of female hospital workers with low job seniority, and those caring for COVID-19 patients. CONCLUSIONS: Our findings reported a sig- nificant psychosocial impact of the COVID-19 outbreak on Italian doctors, particularly among those working in the most affected regions of the country. Further studies are necessary to better understand the effects of the COVID-1

Pharmacists' mental health during the SARS-CoV-2 pandemic in Italy

OBJECTIVE: The year 2020 was characterized by the outbreak of a new pandemic caused by a novel coronavirus named SARSCoV- 2. To face the pandemic, many countries worldwide imposed general lockdowns, closing all non-essential businesses. As primary care services, pharmacies had to remain open, thus putting pharmacy staff at significant risk of viral infection and overwork. This study aimed to assess the mental health of Italian Pharmacists, considering demographic and occupational characteristics, lifestyle, and habits, during the SARS-CoV-2 outbreak and the subsequent lockdown period (March-May 2020). MATERIALS AND METHODS: A web-based survey was created using Google® Forms to collect data from March 30, 2020, to June 1, 2020. The questionnaire consisted of three sections investigating: (1) demographic and occupational variables, (2) lifestyle and habits variables, (3) psychological distress and perceived well-being. RESULTS: A total of 401 participants completed the questionnaire. Older workers and those with more work experience reported more psychological stress. Older and female workers, who felt lonely at home and reported psychological stress, perceived poor well-being. CONCLUSIONS: Our findings demonstrate that the Sars-CoV-2 outbreak and subsequent lockdown rules affected pharmacists' mental health and that it is important to put in place preventive measures against the occurrence of mental disorders among them

About interdisciplinary connections teaching technical disciplines by selecting the tracks of learning

В статье рассматриваются вопросы преподавания студентам младших курсов следующих дисциплин: сопротивление материалов, физика, гидравлика. Обращение к рассматриваемой теме вызвано присоединением России к Болонской декларации по высшему образованию. С этого начались реформы в отечественной системе образовании. Реформирование происходит как в содержательном, так и в организационном направлениях. В результате введено трехуровневое образование: бакалавр, магистр, аспирант. Были разработаны и утверждены Федеральные государственные стандарты образования нового поколения. Нововведения анализируются на примере преподавания дисциплинстудентам Строительного и Механико-машиностроительного институтов Уральского федерального университета имени первого Президента России Б.Н.Ельцина (УрФУ).This article deals with the teaching of the most important disciplines for undergraduates: strength of materials, physics, hydraulics. Appeal to the topic due to Russia's accession to the Bologna Declaration on Higher Education. This started a reform of our education system. Reforming occurs both in substance and in organizational directions. As a result, introduced a three-level education: Bachelor, Master and PhD student. Federal State Educational Standards of a new generation were developed and approved. Innovations are analyzed as an example of teaching disciplines for students of Institute of Civil Engineering and of Institute of Mechanics and Machine Building of the Ural Federal University named after the first President of Russia Boris Yeltsin (UrFU)

Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome

© 2014, Springer-Verlag Berlin Heidelberg. Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As the disease progresses, hemorrhagic disturbances and kidney dysfunctions predominate. The examination of tissue collected postmortem supports the premise that virus replication is not responsible for this pathology; therefore, it is widely believed that virus-induced immune responses lead to the clinical manifestations associated with HFRS. The overproduction of inflammatory cytokines is commonly reported in subjects with HFRS and has given rise to the hypothesis that a so-called “cytokine storm” may play a pivotal role in the pathogenesis of this disease. Currently, supportive care remains the only effective treatment for HFRS. Our data show that serum levels of interferon (IFN)-γ, interleukin (IL)-10, CCL2, and IL-12 are upregulated in HFRS cases when compared to healthy controls and the level of upregulation is dependent on the phase and severity of the disease. Furthermore, we observed an association between the mild form of the disease and elevated serum levels of IFN-γ and IL-12. Collectively, these observations suggest that the administration of exogenous IFN-γ and IL-12 may provide antiviral benefits for the treatment of HFRS and, thus, warrants further investigations

Thermochemistry of heteroatomic compounds X. The thermochemistry of solution and solvation of substituted alkylphosphonic derivatives

The enthalpies of vaporization of different classes of phosphorylated alcohols and amines were determined from their enthalpies of solution in hexane and carbon tetrachloride. The enthalpies of specific (hydrogen-bond) interaction with the solvents (chloroform and pyridine) of derivatives containing X-H groups (X=O or N) in the α-position to the P=O group were detemined. The results were explained in terms of the spatial structure of such compounds