Silver oxalate-based solders: New materials for high thermal conductivity microjoining

Micrometric oxalate powders can be decomposed starting from temperatures as low as 90°C, leading to the formation of temporary nanometric grains of metallic silver with a high propensity for sintering. The decomposition being highly exothermic, this additional energy favours the sintering, i.e. the soldering, process. Solders processed at 300°C and very low pressure (<0.5 MPa) displayed a thermal conductivity close to 100 W m-1 K-1, making silver oxalate very promising for safe, moderate temperature and very low pressure bonding

Effect of cooling rate and aluminium addition on graphite growth during solidification and graphitization

Even using high inoculation levels, mottled structures are often obtained when casting Mg-treated cast irons in thin wall parts. For full graphitization of the cast components, this calls for a subsequent heat-treatment which is generally achieved in the austenite field. The aim of this work was investigating the impact of the process and the cooling rate on the graphite structure for two different casting conditions. The influence of the cooling rate on graphite degeneracy due to the presence of impurity was also investigated considering low-level additions of aluminium. Extensive metallographic investigation has been carried out from which it is concluded that the internal graphite structure is the same for the two studied cooling conditions. Accordingly, the growth mechanism of graphite should be the same when it precipitates from liquid, during eutectic reaction or else solid-state graphitization. Finally, microanalyses suggest magnesium and aluminium do not interact in the same way with graphite during its growth

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock

La musique des Quatre Eléments -concerto pour flûte, chœur d’enfants et percussions de Sophie Lacaze

International audienc

Sophie Lacaze, portrait d'une compositrice. Dialogues avec Geneviève Mathon

International audienc

Sophie Lacaze, portrait d'une compositrice. Dialogues avec Geneviève Mathon

International audienc

La musique des Quatre Eléments -concerto pour flûte, chœur d’enfants et percussions de Sophie Lacaze

International audienc

Pratique de la gynécologie-obstétrique au sein d'une population de 74 médecins généralistes

POITIERS-BU Médecine pharmacie (861942103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Rupture prématurée des membranes entre 24 et 32 SA (facteurs pronostics périnataux, pronostic à 3 ans)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Public involvement activities in 96 global genomics projects

<div>There is a growing need to involve the public more in genomics research. High-profile genomics research initiatives have made public</div><div>statements about the importance of involving people, yet there has been no review of how people are being involved in human genomic research. This study reviewed the public-domain websites of 96 genomics initiatives affiliated with Global Alliance for Genomics and Health (GA4GH) to document the frequency, method, tasks and self-reported outcomes of involving people in genomics research. </div><div><br></div