Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility

This is the peer reviewed version of the following article: Andrologia 50.10 (2018): e13115, which has been published in final form at https://doi.org/10.1111/and.13115. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsThe DNA repair capacity in the mature spermatozoa is highly compromised due to the base-excision repair (BER) route being truncated. In the mature spermatozoa, only the first enzyme of the route (OGG1) is present. Consequently, reduced activity of the enzymes of the BER route both during spermatogenesis and in the mature spermatozoa may be detrimental for fertility. The objective of our study was to investigate the correlation between two representative SNPs of those enzymes, SNPs OGG1 Ser326Cys (rs1052133) and XRCC1 Arg399Gln (rs25487) and male infertility. A total of 313 seminal samples from infertile patients and 80 from donors with proven fertility were included in the study. All samples were subjected to a regular sperm analysis and genotyped using the PCR-RFLP system. We found significant differences in the genotype frequencies between patients and donors for the XRCC1 Arg399Gln polymorphism (χ2(2) = 8.7, p = 0.013), with the Gln allele showing a protective role and for the OGG1 Ser326Cys polymorphism between normozoospermic and non-normozoospermic patients (χ2(2) = 12.67, p = 0.002) with the Cys allele showing a detrimental effect over concentration. In conclusion, our study shows that polymorphisms in the genes coding for the DNA damage repair enzymes may be associated with poor sperm parameters and male infertilit

Closing the gap: the link between social capital and microfinance services

The social capital has strengthened the solidarity funds when the legal mechanisms and institutions for monitoring and assistance would not have been present. The aim of this paper is to analyze the effect of social capital on productivity and performance of the Mexican solidarity funds. For this it is obtained an estimator indirectly associated with inequality, through which it follows that if the social capital rises 1% the loans number increases by 0.2877% and the savings number increases by 0.4598%, and for each additional producer that activate his social capital with his partners they will be generated increases in loans recoveries amounting to 597.41 pesos. In this sense, a greater investment in social capital will recover a larger amount of borrowed funds and will increase savings and loans to poor producer

Closing the gap: the link between social capital and microfinance services

The social capital has strengthened the solidarity funds when the legal mechanisms and institutions for monitoring and assistance would not have been present. The aim of this paper is to analyze the effect of social capital on productivity and performance of the Mexican solidarity funds. For this it is obtained an estimator indirectly associated with inequality, through which it follows that if the social capital rises 1% the loans number increases by 0.2877% and the savings number increases by 0.4598%, and for each additional producer that activate his social capital with his partners they will be generated increases in loans recoveries amounting to 597.41 pesos. In this sense, a greater investment in social capital will recover a larger amount of borrowed funds and will increase savings and loans to poor producer

Social Capital in the Presence of Market Failures

In Mexico, social capital is used to get resources. People who do not have access to formal markets use their networks to acquire public and financing services, social insurance and social benefits. To test this, social capital indicators were built using the resources supplied by people as a proportion of their income. This measure is theoretically related to a sympathy coefficient that represents the degree to which a person joins another´s welfare in its utility function, leading him to share resources with others. Synthetic panels with population cohorts were elaborated to follow population throughout the time. To correct a spurious regression problem, the cointegration-panel method was used. As a result, variables that reflect failures in financial, health and social insurance markets are associated to bonding and bridging social capital indicators. Thus, adjustments in these markets could be explained by social capital variables additionally to market prices mechanisms

Social Capital in the Presence of Market Failures

In Mexico, social capital is used to get resources. People who do not have access to formal markets use their networks to acquire public and financing services, social insurance and social benefits. To test this, social capital indicators were built using the resources supplied by people as a proportion of their income. This measure is theoretically related to a sympathy coefficient that represents the degree to which a person joins another´s welfare in its utility function, leading him to share resources with others. Synthetic panels with population cohorts were elaborated to follow population throughout the time. To correct a spurious regression problem, the cointegration-panel method was used. As a result, variables that reflect failures in financial, health and social insurance markets are associated to bonding and bridging social capital indicators. Thus, adjustments in these markets could be explained by social capital variables additionally to market prices mechanisms

Multifunctional Eu-doped NaGd(MoO4)(2) nanoparticles functionalized with poly(L-lysine) for optical and MRI imaging

A method for the synthesis of non-aggregated and highly uniform Eu3+ doped NaGd(MoO4)(2) nanoparticles is reported for the first time. The obtained particles present tetragonal structure, ellipsoidal shape and their size can be varied by adjusting the experimental synthesis parameters. These nanoparticles, which were coated with citrate anions and functionalised with PLL, have also been developed in order to improve their colloidal stability in physiological medium (2-(N-morpholino) ethanesulfonic acid, MES). A study of the luminescent dynamics of the samples as a function of the Eu doping level has been conducted in order to find the optimum nanophosphors, whose magnetic relaxivity and cell viability have also been evaluated for the first time for this system, in order to assess their suitability as multifunctional probes for optical (in vitro) and magnetic bioimaging applications

Radiation-damage produced in BaHfO₃ irradiated with thermal and fast-neutrons

Samples of BaHfO₃ were irradiated with fast and thermal neutrons to produce ^181Hf. Attenuations of the gamma-gamma perturbed angular correlations in ^181Ta were observed, and they may have been caused by the interaction between defects (produced during or after neutron irradiation) and oxygen vacancies. Several defect structures were detected. For one of the structures, an excitation energy of 12 meV was measured, which was attributed to an electron state below the conduction band. The values of the dielectric constant and of the effective electron mass were also deduced

Análisis exploratorio de firmas espectrales e índices de vegetación para la monitorización de emisiones de CO2 en un análogo natural.

Se ha analizado el problema de la detección de fugas de CO2 en reservorios naturales utilizados como almacenes de este gas. Los trabajos han sido realizados sobre un área del Campo de Calatrava, Ciudad Real, España, donde a causa de la actividad volcánica remanente se pueden encontrar puntos de emisión de CO2. Se han utilizado imágenes QuickBird y WorldView-2 para la generación de firmas espectrales e índices de vegetación. Estos índices han sido evaluados para obtener los más idóneos para la detección de fugas de CO2. Palabras clave: teledetección, CO2, vegetación, satélite. ABSTRACT The problem of detecting CO2 leaks in natural reservoirs used to store the gas has been analyzed. The works have been done over an area where, because of the residual volcanic activity, CO2 delivery spots can be found. This area is located in Campo de Calatrava, Ciudad Real, Spain. QuickBird and WorldView-2 imagery has been used to generate spectral signatures and vegetation indexes. These indexes have been evaluated in order to obtain the most suitable ones to detect CO2 leaks. Keywords: remote sensing, CO2, vegetation, satellite

Monitorización de emisiones de CO2 en un análogo natural mediante correlación con Índices de Vegetación

Entre las soluciones más satisfactorias al problema de las emisiones de CO2 está la captura y almacenamiento de este gas de efecto invernadero en reservorios profundos. Esta técnica implica la necesidad de monitorizar grandes extensiones de terreno. Utilizando una zona de vulcanismo residual, en la provincia de Ciudad Real, se han monitorizado las emisiones de CO2 utilizando imágenes de muy alta resolución espacial. Se han generado índices de vegetación, y estos se han correlacionado con medidas de contenido de CO2 del aire en los puntos de emisión. Los resultados han arrojado niveles de correlación significativos (p. ej.: SAVI = -0,93) y han llevado a descubrir un nuevo punto de emisión de CO2. Palabras clave: teledetección, CO2, vegetación, satélite Monitoring CO2 emissions in a natural analogue by correlating with vegetation indices Abstract: Among the most satisfactory solutions for the CO2 emissions problem is the capture and storage of this greenhouse gas in deep reservoirs. This technique involves the need to monitor large areas. Using a volcanic area with residual activity, in the province of Ciudad Real, CO2 emissions were monitored through very high spatial resolution imagery. Vegetation indexes were generated and correlated with measurements of the air?s CO2 content at the emission points. The results yielded significant correlation levels (e.g.: SAVI = -0.93) and led to the discovery of a new CO2 emission point. Keywords: remote sensing, CO2, vegetation, satellite