202 research outputs found
EGAM Induced by Energetic-electrons and Nonlinear Interactions among EGAM, BAEs and Tearing Modes in a Toroidal Plasma
In this letter, it is reported that the first experimental results are
associated with the GAM induced by energetic electrons (eEGAM) in HL-2A Ohmic
plasma. The energetic-electrons are generated by parallel electric fields
during magnetic reconnection associated with tearing mode (TM). The eEGAM
localizes in the core plasma, i.e. in the vicinity of q=2 surface, and is very
different from one excited by the drift-wave turbulence in the edge plasma. The
analysis indicated that the eEGAM is provided with the magnetic components,
whose intensities depend on the poloidal angles, and its mode numbers are
jm/nj=2/0. Further, there exist intense nonlinear interactions among eEGAM,
BAEs and strong tearing modes (TMs). These new findings shed light on the
underlying physics mechanism for the excitation of the low frequency (LF)
Alfv\'enic and acoustic uctuations.Comment: 5 pages,4 figure
Pinning of a solid--liquid--vapour interface by stripes of obstacles
We use a macroscopic Hamiltonian approach to study the pinning of a
solid--liquid--vapour contact line on an array of equidistant stripes of
obstacles perpendicular to the liquid. We propose an estimate of the density of
pinning stripes for which collective pinning of the contact line happens. This
estimate is shown to be in good agreement with Langevin equation simulation of
the macroscopic Hamiltonian. Finally we introduce a 2--dimensional mean field
theory which for small strength of the pinning stripes and for small capillary
length gives an excellent description of the averaged height of the contact
line.Comment: Plain tex, 12 pages, 3 figures available upon reques
Dynamic Ordering and Transverse Depinning of a Driven Elastic String in a Disordered Media
We examine the dynamics of an elastic string interacting with quenched
disorder driven perpendicular and parallel to the string. We show that the
string is the most disordered at the depinning transition but with increasing
drive partial ordering is regained. For low drives the noise power is high and
we observe a 1/f^2 noise signature crossing over to a white noise character
with low power at higher drives. For the parallel driven moving string there is
a finite transverse critical depinning force with the depinning transition
occuring by the formation of running kinks.Comment: 4 pages, 4 postscript figure
Ownership and control in a competitive industry
We study a differentiated product market in which an investor initially owns a controlling stake in one of two competing firms and may acquire a non-controlling or a controlling stake in a competitor, either directly using her own assets, or indirectly via the controlled firm. While industry profits are maximized within a symmetric two product monopoly, the investor attains this only in exceptional cases. Instead, she sometimes acquires a noncontrolling stake. Or she invests asymmetrically rather than pursuing a full takeover if she acquires a controlling one. Generally, she invests indirectly if she only wants to affect the product market outcome, and directly if acquiring shares is profitable per se. --differentiated products,separation of ownership and control,private benefits of control
Measurements of the Mass and Full-Width of the Meson
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five different decay
channels: , , (with ), (with
) and . From a combined fit of all five
channels, we determine the mass and full-width of to be
MeV/ and
MeV/.Comment: 9 pages, 2 figures and 4 table. Submitted to Phys. Lett.
Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach
Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent–child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case–control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive–compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were tagging SNPs from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top SNPs from TS GWAS; and 13 top SNPs from attention-deficit/hyperactivity disorder, OCD, or ASD GWAS. None of the SNPs or genes reached significance after adjustment for multiple testing. We observed nominal significance for the candidate SNPs rs3744161 (TBCD) and rs4565946 (TPH2) and for five tagging SNPs; none of these showed significance in the independent cohort. Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM). We found no convincing support for previously implicated genetic polymorphisms. Targeted re-sequencing should fully appreciate the relevance of candidate genes
Designing a broad-spectrum integrative approach for cancer prevention and treatment
Targeted therapies and the consequent adoption of "personalized" oncology have achieved notablesuccesses in some cancers; however, significant problems remain with this approach. Many targetedtherapies are highly toxic, costs are extremely high, and most patients experience relapse after a fewdisease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistantimmortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are notreliant upon the same mechanisms as those which have been targeted). To address these limitations, aninternational task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspectsof relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a widerange of high-priority targets (74 in total) that could be modified to improve patient outcomes. For thesetargets, corresponding low-toxicity therapeutic approaches were then suggested, many of which werephytochemicals. Proposed actions on each target and all of the approaches were further reviewed forknown effects on other hallmark areas and the tumor microenvironment. Potential contrary or procar-cinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixedevidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of therelationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. Thisnovel approach has potential to be relatively inexpensive, it should help us address stages and types ofcancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for futureresearch is offered
Measurement of Branching Ratios for Hadronic Decays
In a sample of 58 million events collected with the BES II detector,
the process J/ is observed in five decay channels: , , (with
), (with ) and . From
these signals, we determine ,
, ,
and .Comment: 8 pages, 1 figures and 4 table. Submitted to Phys. Lett.
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