585 research outputs found
High-level cognition during story listening is reflected in high-order dynamic correlations in neural activity patterns
Our thoughts arise from coordinated patterns of interactions between brain structures that change with our ongoing experiences. High-order dynamic correlations in neural activity patterns reflect different subgraphs of the brain’s functional connectome that display homologous lower-level dynamic correlations. Here we test the hypothesis that high-level cognition is reflected in high-order dynamic correlations in brain activity patterns. We develop an approach to estimating high-order dynamic correlations in timeseries data, and we apply the approach to neuroimaging data collected as human participants either listen to a ten-minute story or listen to a temporally scrambled version of the story. We train across-participant pattern classifiers to decode (in held-out data) when in the session each neural activity snapshot was collected. We find that classifiers trained to decode from high-order dynamic correlations yield the best performance on data collected as participants listened to the (unscrambled) story. By contrast, classifiers trained to decode data from scrambled versions of the story yielded the best performance when they were trained using first-order dynamic correlations or non-correlational activity patterns. We suggest that as our thoughts become more complex, they are reflected in higher-order patterns of dynamic network interactions throughout the brain
Pharmacokinetic profile of irinotecan in patients with chronic kidney disease:Two cases and literature review
Aims: There are limited pharmacokinetic data on the use of irinotecan in patients with reduced glomerular filtration rate (GFR) and no haemodialysis. In this case report, we present 2 cases and review the current literature. Methods: The dose of irinotecan in both patients was reduced pre-emptively due to reduced GFR. The first patient had her irinotecan dose reduced to 50%, but was nevertheless admitted to hospital because of irinotecan-induced toxicity, including gastrointestinal toxicity and neutropenic fever. The dose was reduced further to 40% for the second cycle; however, the patient was again admitted to the hospital, and irinotecan was stopped indefinitely. The second patient also had his irinotecan dose reduced to 50% and was admitted to the emergency department for gastrointestinal toxicity after the first cycle. However, irinotecan could be administered in the same dose in later cycles. Results: The area under the curve to infinity of irinotecan and SN-38 in the first patient were comparable to those of an individual receiving 100% dose intensity. The area under the curve to infinity of irinotecan and SN-38 in patient 2 in both cycles were slightly less than reference values. Furthermore, clearance values of irinotecan and SN-38 in our patients were comparable to those without renal impairment. Conclusion: Our case report suggests that reduced GFR may not significantly affect the clearance of irinotecan and SN-38, but can still result in clinical toxicity. Reduced initial dosing seems indicated in this patient population. Further research is needed to fully understand the relationship between reduced GFR, pharmacokinetics, and toxicity of irinotecan and SN-38.</p
High Magnetic Field Microwave Conductivity of 2D Electrons in an Array of Antidots
We measure the high magnetic field () microwave conductivity,
Re, of a high mobility 2D electron system containing an antidot
array. Re vs frequency () increases strongly in the regime of
the fractional quantum Hall effect series, with Landau filling .
At microwave , Re vs exhibits a broad peak centered around
. On the peak, the 10 GHz Re can exceed its dc-limit
value by a factor of 5. This enhanced microwave conductivity is unobservable
for temperature K, and grows more pronounced as is
decreased. The effect may be due to excitations supported by the antidot edges,
but different from the well-known edge magnetoplasmons.Comment: 4 pages, 3 figures, revtex
Thin helium film on a glass substrate
We investigate by Monte Carlo simulations the structure, energetics and
superfluid properties of thin helium-four films (up to four layers) on a glass
substrate, at low temperature. The first adsorbed layer is found to be solid
and "inert", i.e., atoms are localized and do not participate to quantum
exchanges. Additional layers are liquid, with no clear layer separation above
the second one. It is found that a single helium-three impurity resides on the
outmost layer, not significantly further away from the substrate than
helium-four atoms on the same layer.Comment: Six figures, submitted for publication to the Journal of Low
Temperature Physic
Spin-current modulation and square-wave transmission through periodically stubbed electron waveguides
Ballistic spin transport through waveguides, with symmetric or asymmetric
double stubs attached to them periodically, is studied systematically in the
presence of a weak spin-orbit coupling that makes the electrons precess. By an
appropriate choice of the waveguide length and of the stub parameters injected
spin-polarized electrons can be blocked completely and the transmission shows a
periodic and nearly square-type behavior, with values 1 and 0, with wide gaps
when only one mode is allowed to propagate in the waveguide. A similar behavior
is possible for a certain range of the stub parameters even when two-modes can
propagate in the waveguide and the conductance is doubled. Such a structure is
a good candidate for establishing a realistic spin transistor. A further
modulation of the spin current can be achieved by inserting defects in a
finite-number stub superlattice. Finite-temperature effects on the spin
conductance are also considered.Comment: 19 pages, 8 figure
Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis
A Multilevel Product Model for Simulation-Based Design of Mechanical Systems
This paper presents a multilevel product model that supports Simulation-Based Design (SBD) of mechanical systems, from pre liminary to detailed design stages The pnmary goal of the SBD is to achieve product designs featuring better performance and greater du rability and reliability through computer-based modeling, engineering analysis, and design trade-off. A Computer-Aided Design (CAD) model combined with engineering parameters and mathematical equations that simulate physical behavior of the mechanical system constitute its product model for SBD. For preliminary design, improvement of system performance, including dynamics and human factors, is usually the primary focus A CAD model with reasonably accurate physical parameters, such as mass properties of major components or assemblies, is defined as the base definition of the product model for SBD. A number of simulation models are derived from the base definition to sup port simulation of the mechanical system performance A parametric study can be conducted to search for design alternatives using dimen sion parameters created in the parameterized CAD model. The CAD model and base definition are then refined from the preliminary design stage to support intermediate designs. Intermediate designs will primarily focus on product subsystem performance. A product model is evolved by refining geometric representation of mechanical components in CAD, and expanding product assembly into parts and sub assemblies for further engineering analysis Component designs for performance, such as fatigue, mechanical reliability, and structural per formance, as well as maintainability are the primary focus in the detailed design stage. A detailed product model evolved from that of the previous design is needed In the detailed design stage, a systematic design trade-off method supports design improvement. A High Mobil ity Multi-Purpose Wheeled Vehicle (HMMWV) is employed to illustrate and demonstrate the proposed product model.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
Mapping the Two-Component Atomic Fermi Gas to the Nuclear Shell-Model
The physics of a two-component cold fermi gas is now frequently addressed in
laboratories. Usually this is done for large samples of tens to hundreds of
thousands of particles. However, it is now possible to produce few-body systems
(1-100 particles) in very tight traps where the shell structure of the external
potential becomes important. A system of two-species fermionic cold atoms with
an attractive zero-range interaction is analogous to a simple model of nucleus
in which neutrons and protons interact only through a residual pairing
interaction. In this article, we discuss how the problem of a two-component
atomic fermi gas in a tight external trap can be mapped to the nuclear shell
model so that readily available many-body techniques in nuclear physics, such
as the Shell Model Monte Carlo (SMMC) method, can be directly applied to the
study of these systems. We demonstrate an application of the SMMC method by
estimating the pairing correlations in a small two-component Fermi system with
moderate-to-strong short-range two-body interactions in a three-dimensional
harmonic external trapping potential.Comment: 13 pages, 3 figures. Final versio
Non Linear Current Response of a Many-Level Tunneling System: Higher Harmonics Generation
The fully nonlinear response of a many-level tunneling system to a strong
alternating field of high frequency is studied in terms of the
Schwinger-Keldysh nonequilibrium Green functions. The nonlinear time dependent
tunneling current is calculated exactly and its resonance structure is
elucidated. In particular, it is shown that under certain reasonable conditions
on the physical parameters, the Fourier component is sharply peaked at
, where is the spacing between
two levels. This frequency multiplication results from the highly nonlinear
process of photon absorption (or emission) by the tunneling system. It is
also conjectured that this effect (which so far is studied mainly in the
context of nonlinear optics) might be experimentally feasible.Comment: 28 pages, LaTex, 7 figures are available upon request from
[email protected], submitted to Phys.Rev.
- …