Compression of aerodynamic databases using high-order singular value decomposition

A methodology based on high-order singular value decomposition is presented to compress multidimensional (with the various dimensions associated with both the spatial coordinates and parameter values) aerodynamic databases. The method is illustrated with a database containing computational fluid dynamics calculations of the outer flow around a wing, with two free parameters, the Mach number and the angle of attack. Comparison is made between the results of compressing just one flow snapshot (for fixed values of the parameters), compressing a one-parameter family of snapshots, and compressing the whole database. Several compressing strategies are also discussed that deal with (a) treating the flow variables separately or considering all flow variables at a time, (b) considering the whole flow domain simultaneously or dividing it into blocks, and (c) using various measures of errors. The main conclusion is that a large compression factor is generally obtained. Furthermore, the compression factor increases exponentially as the dimension of the database increases for any fixed error, namely the compression factor increases by an order of magnitude with each new database dimension for an error level of 1%

Neuro-immune interactions in health and disease: Insights from FENS-Hertie 2022 Winter School.

In a great partnership, the Federation of European Neuroscience Societies (FENS) and the Hertie Foundation organized the FENS-Hertie 2022 Winter School on 'Neuro-immune interactions in health and disease'. The school selected 27 PhD students and 13 postdoctoral fellows from 20 countries and involved 14 faculty members experts in the field. The Winter School focused on a rising field of research, the interactions between the nervous and both innate and adaptive immune systems under pathological and physiological conditions. A fine-tuned neuro-immune crosstalk is fundamental for healthy development, while disrupted neuro-immune communication might play a role in neurodegeneration, neuroinflammation and aging. However, much is yet to be understood about the underlying mechanisms of these neuro-immune interactions in the healthy brain and under pathological scenarios. In addition to new findings in this emerging field, novel methodologies and animal models were presented to foment research on neuro-immunology. The FENS-Hertie 2022 Winter School provided an insightful knowledge exchange between students and faculty focusing on the latest discoveries in the biology of neuro-immune interactions while fostering great academic and professional opportunities for early-career neuroscientists from around the world