Lathrophytoic acids A and B: two novel polyprenylated phloroglucinol derivatives from Kielmeyera lathrophyton

AbstractTwo novel polyprenylated phloroglucinol derivatives were isolated from the trunk of Kielmeyera lathrophyton (Clusiaceae). Lathrophytoic acid A presented an unusual caged carbon skeleton with a 1,3-dione-4-cyclopentanol moiety. Lathrophytoic acid B exhibited a highly substituted bicycle[3.3.1]nonane skeleton and an isopropylfuran system which was formed by unusual cyclization of a prenyloxy side chain

Portuguese Ministers, 1851-1999: Social Background and Paths to Power

Disponível em: http://193.136.113.6/Opac/Pages/Search/Results.aspx?SearchText=UID=bb8aa8d5-c6b6-466a-81bb-fe8a67693cee&DataBase=10449_UNLFCSHThis paper provides an empirical analysis of the impact of regime changes in the composition and patterns of recruitment of the Portuguese ministerial elite throughout the last 150 years. The ‘out-of-type’, violent nature of most regime transformations accounts for the purges in and the extensive replacements of the political personnel, namely of the uppermost officeholders. In the case of Cabinet members, such discontinuities did not imply, however, radical changes in their social profile. Although there were some significant variations, a series of salient characteristics have persisted over time. The typical Portuguese minister is a male in his midforties, of middle-class origin and predominantly urban-born, highly educated and with a state servant background. The two main occupational contingents have been university professors - except for the First Republic (1910-26) - and the military, the latter having only recently been eclipsed with the consolidation of contemporary democracy. As regards career pathways, the most striking feature is the secular trend for the declining role of parliamentary experience, which the democratic regime did not clearly reverse. In this period, a technocratic background rather than political experience has been indeed the privileged credential for a significant proportion of minister

Polymorphism In Lep And Lepr May Modify Leptin Levels And Represent Risk Factors For Thyroid Cancer

Purpose. To understand the role of polymorphisms in the LEP (rs7799039 and rs2167270) and LEPR (rs1137101 and rs1137100) genes in DTC susceptibility and their effect on leptin levels. Methods. We studied 153 patients with DTC and 234 controls through TaqMan SNP Genotyping and ELISA, comparing these data to the clinicopathological data of patients with DTC. Results. Patients with AA genotype of rs7799039 had higher levels of serum leptin (9.22 ± 0.98 ng/mL) than those with AG genotype (10.07 ± 0.60 ng/mL; P = 0.005). Individuals with AG genotype of rs2167270 also produced higher serum leptin levels (10.05 ± 0.59 ng/mL) than the subjects with GG genotype (9.52 ± 0.79 ng/mL; P A) polymorphism and disease susceptibility and cardiovascular disease in patients with rheumatoid arthritis (2011) Clinical and Experimental Rheumatology, 29 (2), pp. 293-298Jiang, Y., Wilk, J.B., Borecki, I., Common variants in the 5' region of the leptin gene are associated with bodymass index in men fromthe National Heart, Lung, and Blood Institute Family Heart Study (2004) The American Journal of Human Genetics, 75 (2), pp. 220-230He, J., Xi, B., Ruiter, R., Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: Evidence froma meta-analysis (2013) PLoS ONE, 8 (10)Furusawa, T., Naka, I., Yamauchi, T., The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders (2010) Human Genetics, 127 (3), pp. 287-294Saukko, M., Kesäniemi, Y.A., Ukkola, O., Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis (2010) Metabolic Syndrome and Related Disorders, 8 (5), pp. 425-430Lucas, A., Granada, M.L., Olaizola, I., Leptin and thyrotropin relationship is modulated by smoking status in euthyroid subjects (2013) Thyroid, 23 (8), pp. 964-970Duntas, L.H., Biondi, B., The interconnections between obesity, thyroid function, and autoimmunity: Themultifold role of leptin (2013) Thyroid, 23 (6), pp. 646-653Marzullo, P., Minocci, A., Tagliaferri, M.A., Investigations of thyroid hormones and antibodies in obesity: Leptin levels are associated with thyroid autoimmunity independent of bioanthropometric, hormonal, and weight-related determinants (2010) Journal of Clinical Endocrinology and Metabolism, 95 (8), pp. 3965-3972Guzel, S., Seven, A., Guzel, E.C., Buyuk, B., Celebi, A., Aydemir, B., Visfatin, leptin, and TNF-α: Interrelated adipokines in insulin-resistant clinical and subclinical hypothyroidism (2013) Endocrine Research, 38 (3), pp. 184-194Mammès, O., Betoulle, D., Aubert, R., Herbeth, B., Siest, G., Fumeron, F., Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight (2000) Annals of Human Genetics, 64 (5), pp. 391-394Portoles, O., Sorli, J.V., Frances, F., Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain (2006) European Journal of Epidemiology, 21 (8), pp. 605-612Liu, C., Liu, L., Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: A metaanalysis (2011) Tumour Biology, 32 (6), pp. 1233-1240Hoffsted, J., Eriksson, P., Mottagui-Tabar, S., Arner, P., A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin (2002) Hormone and Metabolic Research, 34 (7), pp. 355-359Murugesan, D., Arunachalam, T., Ramamurthy, V., Subramanian, S., Association of polymorphisms in leptin receptor gene with obesity and type 2 diabetes in the local population of Coimbatore (2010) Indian Journal of Human Genetics, 16 (2), pp. 72-77Quinton, N.D., Lee, A.J., Ross, R.J.M., Eastell, R., Blakemore, A.I.F., A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fatmass and leptin levels in postmenopausal Caucasian women (2001) Human Genetics, 108 (3), pp. 233-236Mattevi, V.S., Zembrzuski, V.M., Hutz, M.H., Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil (2002) International Journal of Obesity, 26 (9), pp. 1179-1185Yiannakouris, N., Yannakoulia, M., Melistas, L., Chan, J.L., Klimis-Zacas, D., Mantzoros, C.S., TheQ223Rpolymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of bodyweight and body composition variability (2001) Journal of Clinical Endocrinology and Metabolism, 86 (9), pp. 4434-4439Stefan, N., Vozarova, B., Del Parigi, A., The Gln223Arg polymorphism of the leptin receptor in Pima Indians: Influence on energy expenditure, physical activity and lipid metabolism (2002) International Journal of Obesity, 26 (12), pp. 1629-1632Chiu, K.C., Chu, A., Chuang, L.-M., Saad, M.F., Association of leptin receptor polymorphism with insulin resistance (2004) European Journal of Endocrinology, 150 (5), pp. 725-729Chu, A., Chuang, L.M., Saad, M., Chiu, K., Association of the Q223R polymorphism of the leptin receptor gene with insulin resistance and metabolic syndrome (2003) Diabetes, 52, p. A510Pimentel Duarte, S.F., Francischetti, E.A., Genelhu-Abreu, V., P. 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