Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar

The International Mouse Phenotyping Consortium (IMPC): A functional catalogue of the mammalian genome that informs conservation (vol 19, pg 995, 2018).

The original publication of this article unfortunately contained the following mistakes

Viewing angles in some selected BL Lac objects

A selected subset of BL Lac objects were monitored with VLBI techniques at multifrequencies. Apparent superlumJnal motion and X-rays were detected in all of the monitored sources. From the observational data, kinematic parameters, geometric parameters and beaming effects for the 'core' of the selected BL Lac objects have been estimated. Our results indicate that some BL Lacs have large Lorentz factors and small viewing angles; relativistic beaming effects are strongly present in these sources. On the other hand, some BL Lacs have small Lorentz thctors; their viewing angles are quite large. It does not seem possible to avoid the fact that some BL Lac objects are not oriented particularly close to the line of sight. It conflicts with the basic assumption of the accepted theories for explaining the characteristics of BL Lac objects at present. Also, it seems that the BL Lac objects in the class I of the Burdige and Hewitt's classification have larger viewing angles than those int he class II. The whole BL Lac classification could be a misnomer: the sources classified as 'BL Lac objects' are a mixture of physically different populations with different parent objects

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function