347 research outputs found
Height and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality
OBJECTIVES: Height is inversely associated with cardiovascular disease mortality risk and has shown variable associations with cancer incidence and mortality. The interpretation of findings from previous studies has been constrained by data limitations. Associations between height and specific causes of death were investigated in a large general population cohort of men and women from the West of Scotland.
DESIGN: Prospective observational study.
SETTING: Renfrew and Paisley, in the West of Scotland.
SUBJECTS: 7052 men and 8354 women aged 45-64 were recruited into a study in Renfrew and Paisley, in the West of Scotland, between 1972 and 1976. Detailed assessments of cardiovascular disease risk factors, morbidity and socioeconomic circumstances were made at baseline.
MAIN OUTCOME MEASURES: Deaths during 20 years of follow up classified into specific causes.
RESULTS: Over the follow up period 3347 men and 2638 women died. Height is inversely associated with all cause, coronary heart disease, stroke, and respiratory disease mortality among men and women. Adjustment for socioeconomic position and cardiovascular risk factors had little influence on these associations. Height is strongly associated with forced expiratory volume in one second (FEV1) and adjustment for FEV1 considerably attenuated the association between height and cardiorespiratory mortality. Smoking related cancer mortality is not associated with height. The risk of deaths from cancer unrelated to smoking tended to increase with height, particularly for haematopoietic, colorectal and prostate cancers. Stomach cancer mortality was inversely associated with height. Adjustment for socioeconomic position had little influence on these associations.
CONCLUSION: Height serves partly as an indicator of socioeconomic circumstances and nutritional status in childhood and this may underlie the inverse associations between height and adulthood cardiorespiratory mortality. Much of the association between height and cardiorespiratory mortality was accounted for by lung function, which is also partly determined by exposures acting in childhood. The inverse association between height and stomach cancer mortality probably reflects Helicobacter pylori infection in childhood resulting inor being associated withshorter height. The positive associations between height and several cancers unrelated to smoking could reflect the influence of calorie intake during childhood on the risk of these cancers
Validation of the GROMOS force-field parameter set 45A3 against nuclear magnetic resonance data of hen egg lysozyme
The mass-to-light ratio of rich star clusters
We point out a strong time-evolution of the mass-to-light conversion factor
eta commonly used to estimate masses of unresolved star clusters from observed
cluster spectro-photometric measures. We present a series of gas-dynamical
models coupled with the Cambridge stellar evolution tracks to compute
line-of-sight velocity dispersions and half-light radii weighted by the
luminosity. We explore a range of initial conditions, varying in turn the
cluster mass and/or density, and the stellar population's IMF. We find that
eta, and hence the estimated cluster mass, may increase by factors as large as
3 over time-scales of 50 million years. We apply these results to an hypothetic
cluster mass distribution function (d.f.) and show that the d.f. shape may be
strongly affected at the low-mass end by this effect. Fitting truncated
isothermal (Michie-King) models to the projected light profile leads to
over-estimates of the concentration parameter c of delta c ~ 0.3 compared to
the same functional fit applied to the projected mass density.Comment: 6 pages, 2 figures, to appear in the proceedings of the "Young
massive star clusters", Granada, Spain, September 200
Association of Nonobstructive Chronic Bronchitis with Respiratory Health Outcomes in Adults
Importance: Chronic bronchitis has been associated with cigarette smoking as well as with e-cigarette use among young adults, but the association of chronic bronchitis in persons without airflow obstruction or clinical asthma, described as nonobstructive chronic bronchitis, with respiratory health outcomes remains uncertain. Objective: To assess whether nonobstructive chronic bronchitis is associated with adverse respiratory health outcomes in adult ever smokers and never smokers. Design, Setting, and Participants: This prospective cohort study included 22325 adults without initial airflow obstruction (defined as the ratio of forced expiratory volume in the first second [FEV1] to forced vital capacity [FVC] of <0.70) or clinical asthma at baseline. The National Heart, Lung, and Blood Institute (NHLBI) Pooled Cohorts Study harmonized and pooled data from 9 US general population-based cohorts. Thus present study is based on data from 5 of these cohorts. Participants were enrolled from August 1971 through May 2007 and were followed up through December 2018. Exposures: Nonobstructive chronic bronchitis was defined by questionnaire at baseline as both cough and phlegm for at least 3 months for at least 2 consecutive years. Main Outcomes and Measures: Lung function was measured by prebronchodilator spirometry. Hospitalizations and deaths due to chronic lower respiratory disease and respiratory disease-related mortality were defined by events adjudication and administrative criteria. Models were stratified by smoking status and adjusted for anthropometric, sociodemographic, and smoking-related factors. The comparison group was participants without nonobstructive chronic bronchitis. Results: Among 22325 adults included in the analysis, mean (SD) age was 53.0 (16.3) years (range, 18.0-95.0 years), 58.2% were female, 65.9% were non-Hispanic white, and 49.6% were ever smokers. Among 11082 ever smokers with 99869 person-years of follow-up, participants with nonobstructive chronic bronchitis (300 [2.7%]) had accelerated decreases in FEV1 (4.1 mL/y; 95% CI, 2.1-6.1 mL/y) and FVC (4.7 mL/y; 95% CI, 2.2-7.2 mL/y), increased risks of chronic lower respiratory disease-related hospitalization or mortality (hazard ratio [HR], 2.2; 95% CI, 1.7-2.7), and greater respiratory disease-related (HR, 2.0; 95% CI, 1.1-3.8) and all-cause mortality (HR, 1.5; 95% CI, 1.3-1.8) compared with ever smokers without nonobstructive chronic bronchitis. Among 11243 never smokers with 120004 person-years of follow-up, participants with nonobstructive chronic bronchitis (151 [1.3%]) had greater rates of chronic lower respiratory disease-related hospitalization or mortality (HR, 3.1; 95% CI, 2.1-4.5) compared with never smokers without nonobstructive chronic bronchitis. Nonobstructive chronic bronchitis was not associated with FEV1:FVC decline or incident airflow obstruction. The presence of at least 1 of the component symptoms of nonobstructive chronic bronchitis (ie, chronic cough or phlegm), which was common in both ever smokers (11.0%) and never smokers (6.7%), was associated with adverse respiratory health outcomes. Conclusions and Relevance: The findings suggest that nonobstructive chronic bronchitis is associated with adverse respiratory health outcomes, particularly in ever smokers, and may be a high-risk phenotype suitable for risk stratification and targeted therapies
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Towards Machine Wald
The past century has seen a steady increase in the need of estimating and
predicting complex systems and making (possibly critical) decisions with
limited information. Although computers have made possible the numerical
evaluation of sophisticated statistical models, these models are still designed
\emph{by humans} because there is currently no known recipe or algorithm for
dividing the design of a statistical model into a sequence of arithmetic
operations. Indeed enabling computers to \emph{think} as \emph{humans} have the
ability to do when faced with uncertainty is challenging in several major ways:
(1) Finding optimal statistical models remains to be formulated as a well posed
problem when information on the system of interest is incomplete and comes in
the form of a complex combination of sample data, partial knowledge of
constitutive relations and a limited description of the distribution of input
random variables. (2) The space of admissible scenarios along with the space of
relevant information, assumptions, and/or beliefs, tend to be infinite
dimensional, whereas calculus on a computer is necessarily discrete and finite.
With this purpose, this paper explores the foundations of a rigorous framework
for the scientific computation of optimal statistical estimators/models and
reviews their connections with Decision Theory, Machine Learning, Bayesian
Inference, Stochastic Optimization, Robust Optimization, Optimal Uncertainty
Quantification and Information Based Complexity.Comment: 37 page
Narrative inquiry into (re)imagining alternative schools: a case study of Kevin Gonzales.
Although there are many alternative schools that strive for the successful education for their students, negative images of alternative schools persist. While some alternative schools are viewed as âidealistic havens,â many are viewed as âdumping grounds,â or âjuvenile detention centers.â Employing narrative inquiry, this article interrogates how a student, Kevin Gonzales, experiences his alternative education and raises questions about the role of alternative schools. Kevin Gonzalesâs story is presented in a literary form of biographical journal to provide a âmetaphoric loftâ that helps us imagine other students like Kevin. This, in turn, provokes us to examine our current educational practice, and to (re)imagine ways in which alternative education can provide the best possible educational experiences for disenfranchised students who are increasingly underserved by the public education system
Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study
Background: Former smokers now outnumber current smokers in many developed countries, and current smokers are smoking fewer cigarettes per day. Some data suggest that lung function decline normalises with smoking cessation; however, mechanistic studies suggest that lung function decline could continue. We hypothesised that former smokers and low-intensity current smokers have accelerated lung function decline compared with never-smokers, including among those without prevalent lung disease. Methods: We used data on six US population-based cohorts included in the NHLBI Pooled Cohort Study. We restricted the sample to participants with valid spirometry at two or more exams. Two cohorts recruited younger adults (â„17 years), two recruited middle-aged and older adults (â„45 years), and two recruited only elderly adults (â„65 years) with examinations done between 1983 and 2014. FEV1 decline in sustained former smokers and current smokers was compared to that of never-smokers by use of mixed models adjusted for sociodemographic and anthropometric factors. Differential FEV1 decline was also evaluated according to duration of smoking cessation and cumulative (number of pack-years) and current (number of cigarettes per day) cigarette consumption. Findings: 25 352 participants (ages 17â93 years) completed 70 228 valid spirometry exams. Over a median follow-up of 7 years (IQR 3â20), FEV1 decline at the median age (57 years) was 31·01 mL per year (95% CI 30·66â31·37) in sustained never-smokers, 34·97 mL per year (34·36â35·57) in former smokers, and 39·92 mL per year (38·92â40·92) in current smokers. With adjustment, former smokers showed an accelerated FEV1 decline of 1·82 mL per year (95% CI 1·24â2·40) compared to never-smokers, which was approximately 20% of the effect estimate for current smokers (9·21 mL per year; 95% CI 8·35â10·08). Compared to never-smokers, accelerated FEV1 decline was observed in former smokers for decades after smoking cessation and in current smokers with low cumulative cigarette consumption (<10 pack-years). With respect to current cigarette consumption, the effect estimate for FEV1 decline in current smokers consuming less than five cigarettes per day (7·65 mL per year; 95% CI 6·21â9·09) was 68% of that in current smokers consuming 30 or more cigarettes per day (11·24 mL per year; 9·86â12·62), and around five times greater than in former smokers (1·57 mL per year; 1·00â2·14). Among participants without prevalent lung disease, associations were attenuated but were consistent with the main results. Interpretation: Former smokers and low-intensity current smokers have accelerated lung function decline compared with never-smokers. These results suggest that all levels of smoking exposure are likely to be associated with lasting and progressive lung damage. Funding: National Institutes of Health, National Heart Lung and Blood Institute, and US Environmental Protection Agency
The long-term survival chances of young massive star clusters
We review the long-term survival chances of young massive star clusters
(YMCs), hallmarks of intense starburst episodes often associated with violent
galaxy interactions. We address the key question as to whether at least some of
these YMCs can be considered proto-globular clusters (GCs), in which case these
would be expected to evolve into counterparts of the ubiquitous old GCs
believed to be among the oldest galactic building blocks. In the absence of
significant external perturbations, the key factor determining a cluster's
long-term survival chances is the shape of its stellar initial mass function
(IMF). It is, however, not straightforward to assess the IMF shape in
unresolved extragalactic YMCs. We discuss in detail the promise of using
high-resolution spectroscopy to make progress towards this goal, as well as the
numerous pitfalls associated with this approach. We also discuss the latest
progress in worldwide efforts to better understand the evolution of entire
cluster systems, the disruption processes they are affected by, and whether we
can use recently gained insights to determine the nature of at least some of
the YMCs observed in extragalactic starbursts as proto-GCs. We conclude that
there is an increasing body of evidence that GC formation appears to be
continuing until today; their long-term evolution crucially depends on their
environmental conditions, however.Comment: invited refereed review article; ChJA&A, in press; 33 pages LaTeX (2
postscript figures); requires chjaa.cls style fil
Comment on Spracklandus Hoser, 2009 (Reptilia, Serpentes, ELAPIDAE): request for confirmation of the availability of the generic name and for the nomenclatural validation of the journal in which it was published
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