Формирование супружеской дезадаптации при сексуальном фобическом неврозе у мужа

Освещены причины, условия формирования и клинические проявления вторичной супружеской дезадаптации при сексуальном фобическом неврозе у мужа. Показана роль биогенных, социогенных и негативных психологических факторов в генезе связанной с рассмотренной формой сексуального расстройства супружеской дезадаптации.The causes, conditions of forming and clinical manifestations of secondary spouse deadaptation in sexual phobic neurosis in the husband are described. The role of biogenic, sociogenic and negative mental factors in the development of spouse deadaptation associated with this form of a sexual disorder is shown

Warming, euxinia and sea level rise during the Paleocene–Eocene Thermal Maximum on the Gulf Coastal Plain: implications for ocean oxygenation and nutrient cycling

The Paleocene–Eocene Thermal Maximum(PETM, ?56 Ma) was a ?200 kyr episode of globalwarming, associated with massive injections of 13C-depletedcarbon into the ocean–atmosphere system. Although climatechange during the PETM is relatively well constrained,effects on marine oxygen concentrations and nutrientcycling remain largely unclear. We identify the PETM in asediment core from the US margin of the Gulf of Mexico.Biomarker-based paleotemperature proxies (methylationof branched tetraether–cyclization of branched tetraether(MBT–CBT) and TEX86) indicate that continental air andsea surface temperatures warmed from 27–29 to ?35 ?C,although variations in the relative abundances of terrestrialand marine biomarkers may have influenced these estimates.Vegetation changes, as recorded from pollen assemblages,support this warming.The PETM is bracketed by two unconformities. It overliesPaleocene silt- and mudstones and is rich in angular(thus in situ produced; autochthonous) glauconite grains,which indicate sedimentary condensation. A drop in the relativeabundance of terrestrial organic matter and changesin the dinoflagellate cyst assemblages suggest that risingsea level shifted the deposition of terrigenous material landward.This is consistent with previous findings of eustatic sealevel rise during the PETM. Regionally, the attribution of theglauconite-rich unit to the PETM implicates the dating of aprimate fossil, argued to represent the oldest North Americanspecimen on record.The biomarker isorenieratene within the PETM indicatesthat euxinic photic zone conditions developed, likely seasonally,along the Gulf Coastal Plain. A global data compilationindicates that O2 concentrations dropped in allocean basins in response to warming, hydrological change,and carbon cycle feedbacks. This culminated in (seasonal)anoxia along many continental margins, analogous to moderntrends. Seafloor deoxygenation and widespread (seasonal)anoxia likely caused phosphorus regeneration fromsuboxic and anoxic sediments.We argue that this fueled shelfeutrophication, as widely recorded from microfossil studies,increasing organic carbon burial along many continentalPublished by Copernicus Publications on behalf of the European Geosciences Union.Warming, euxinia and sea level rise during the PETMmargins as a negative feedback to carbon input and globalwarming. If properly quantified with future work, the PETMoffers the opportunity to assess the biogeochemical effects ofenhanced phosphorus regeneration, as well as the timescaleson which this feedback operates in view of modern and futureocean deoxygenation

Anthropometry and Pancreatic Cancer Risk: An Illustration of the Importance of Microscopic Verification

Using data collected of a large population-based cohort study, we studied the association between anthropometric factors and the risk of pancreatic cancer. Furthermore, we investigated whether these associations differ among microscopically confirmed pancreatic cancer (MCPC) cases and non-MCPC (NMCPC) cases. The Netherlands Cohort Study on Diet and Cancer started in 1986 (120,852 men and women) and uses the case-cohort methodology. After 13.3 years of follow-up, 446 pancreatic cancer cases (of which 65% was microscopically confirmed) and 4,774 subcohort members were available for analysis. The multivariable incidence rate ratio of MCPC of men was 1.10 per increment of 1 kg·m-2 (95% confidence interval, 1.04-1.18). Women had a rate ratio of MCPC of 1.08 (95% confidence interval, 1.03-1.13). Obese men [body mass index (BMI) ≥30 kg·m-2] had a 2.6-fold increased risk of MCPC compared with men with BMI 23 to 25 kg·m-2. For women, this increase in risk was 1.7-fold. Change in BMI between age 20 years and baseline was also associated with MCPC in both men and women. In men and women, none of these associations were observed for NMCPC, with the exception of the increased risk for pancreatic cancer in obese men. We observed statistically significant associations between both BMI, gain in BMI, and pancreatic cancer risk. These associations are observed only in MCPC and not in NMCPC. If MCPC and NMCPC had been considered as one group, the reported associations would not have been detected. These findings stress the need to evaluate heterogeneity among pancreatic cancer cases in etiologic studies. Copyright © 2007 American Association for Cancer Research

Alcohol consumption, cigarette smoking, and endometrial cancer risk: results from the Netherlands Cohort Study

OBJECTIVE: To examine the association between alcohol consumption, cigarette smoking, and endometrial cancer. METHODS: In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. RESULTS: After 11.3-years of follow-up, 280 incident endometrial cancer cases were available for analyses. In multivariate analysis, the rate ratio (RR) for alcohol users versus non-users was 1.06 (95% Confidence Interval (95% CI) = 0.78–1.43). There were neither dose-dependent trends nor associations with different types of beverages. The RR for former and current smokers versus never-smokers was 0.83 (95% CI = 0.58–1.20) and 0.59 (95% CI = 0.40–0.88), respectively. These estimates did not change significantly when body mass index (BMI) and age at menopause were added to the models. CONCLUSIONS: There is no association between alcohol consumption and endometrial cancer. Current smoking is associated with a reduced risk of endometrial cancer. This association is neither mediated by BMI nor by age at menopause

A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer

BACKGROUND: Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. METHODS: The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide. RESULTS: After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 mug/day), multivariable-adjusted hazard rate ratios (HR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 mug/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; P(trend) = 0.18], 1.78 (95% CI, 1.10-2.88; P(trend) = 0.02), and 0.93 (95% CI, 0.73-1.19; P(trend) = 0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; P(trend) = 0.03), 2.22 (95% CI, 1.20-4.08; P(trend) = 0.01), and 1.10 (95% CI, 0.80-1.52; P(trend) = 0.55). CONCLUSIONS: We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2304-13). AD - Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands. [email protected]. FAU - Hogervorst, Janneke G AU - Hogervorst JG FAU - Schouten, Leo J AU - Schouten LJ FAU - Konings, Erik J AU - Konings EJ FAU - Goldbohm, R Alexandra AU - Goldbohm RA FAU - van den Brandt, Piet A AU - van den Brandt PA LA - eng PT - Journal Article PL - United States TA - Cancer Epidemiol Biomarkers Prev JT - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncolog

Dietary acrylamide intake and the risk of renal cell, bladder, and prostate cancer

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