Fluctuation induced hopping and spin polaron transport

We study the motion of free magnetic polarons in a paramagnetic background of fluctuating local moments. The polaron can tunnel only to nearby regions of local moments when these fluctuate into alignment. We propose this fluctuation induced hopping as a new transport mechanism for the spin polaron. We calculate the diffusion constant for fluctuation induced hopping from the rate at which local moments fluctuate into alignment. The electrical resistivity is then obtained via the Einstein relation. We suggest that the proposed transport mechanism is relevant in the high temperature phase of the Mn pyrochlore colossal magneto resistance compounds and Europium hexaboride.Comment: 8 pages, 3 figure

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men