The Bethe-Ansatz for N=4 Super Yang-Mills

We derive the one loop mixing matrix for anomalous dimensions in N=4 Super Yang-Mills. We show that this matrix can be identified with the Hamiltonian of an integrable SO(6) spin chain with vector sites. We then use the Bethe ansatz to find a recipe for computing anomalous dimensions for a wide range of operators. We give exact results for BMN operators with two impurities and results up to and including first order 1/J corrections for BMN operators with many impurities. We then use a result of Reshetikhin's to find the exact one-loop anomalous dimension for an SO(6) singlet in the limit of large bare dimension. We also show that this last anomalous dimension is proportional to the square root of the string level in the weak coupling limit.Comment: 35 pages, 3 figures, LaTeX; v2 references added, typos corrected, \Lambda fixed; v3 expanded discussion of higher loops in conclusion, matches published versio

Small deformations of supersymmetric Wilson loops and open spin-chains

We study insertions of composite operators into Wilson loops in N=4 supersymmetric Yang-Mills theory in four dimensions. The loops follow a circular or straight path and the composite insertions transform in the adjoint representation of the gauge group. This provides a gauge invariant way to define the correlator of non-singlet operators. Since the basic loop preserves an SL(2,R) subgroup of the conformal group, we can assign a conformal dimension to those insertions and calculate the corrections to the classical dimension in perturbation theory. The calculation turns out to be very similar to that of single-trace local operators and may also be expressed in terms of a spin-chain. In this case the spin-chain is open and at one-loop order has Neumann boundary conditions on the type of scalar insertions that we consider. This system is integrable and we write the Bethe ansatz describing it. We compare the spectrum in the limit of large angular momentum both in the dilute gas approximation and the thermodynamic limit to the relevant string solution in the BMN limit and in the full AdS_5 x S^5 metric and find agreement.Comment: 40 pages, amstex, 4 figures. V2: Corrected eqn (2.14) and some equations in section 5. Version to appear in JHE

Deconfining Phase Transition as a Matrix Model of Renormalized Polyakov Loops

We discuss how to extract renormalized from bare Polyakov loops in SU(N) lattice gauge theories at nonzero temperature in four spacetime dimensions. Single loops in an irreducible representation are multiplicatively renormalized without mixing, through a renormalization constant which depends upon both representation and temperature. The values of renormalized loops in the four lowest representations of SU(3) were measured numerically on small, coarse lattices. We find that in magnitude, condensates for the sextet and octet loops are approximately the square of the triplet loop. This agrees with a large $N$ expansion, where factorization implies that the expectation values of loops in adjoint and higher representations are just powers of fundamental and anti-fundamental loops. For three colors, numerically the corrections to the large $N$ relations are greatest for the sextet loop, $\leq 25$; these represent corrections of $\sim 1/N$ for N=3. The values of the renormalized triplet loop can be described by an SU(3) matrix model, with an effective action dominated by the triplet loop. In several ways, the deconfining phase transition for N=3 appears to be like that in the $N=\infty$ matrix model of Gross and Witten.Comment: 24 pages, 7 figures; v2, 27 pages, 12 figures, extended discussion for clarity, results unchange

A EXPERIÊNCIA DE HOSPITALIZAÇÃO EXPLICADA PELA PRÓPRIA CRIANÇA

O presente estudo foi realizado com 20 crianças, em idade escolar, internadas em unidades pediátricas. Teve como objetivos identificar: como as crianças expressam a percepção de sua doença e hospitalização; os recursos de 'que elas dispõem para obter conhecimento sobre sua experiência de doença e hospitalização; e seus interesses e preocupações

The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource

BackgroundThe need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project constructed a set of unique and richly annotated tissue microarrays (TMA) from prostate cancer samples obtained from multiple institutions across several global locations.MethodsThree separate TMA sets were built that differ by purpose and disease state.ResultsThe intended use of TMA1 (Primary Matched LN) is to validate biomarkers that help determine which clinically localized prostate cancers with associated lymph node metastasis have a high risk of progression to lethal castration-resistant metastatic disease, and to compare molecular properties of high-risk index lesions within the prostate to regional lymph node metastases resected at the time of prostatectomy. TMA2 (Pre vs. Post ADT) was designed to address questions regarding risk of castration-resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the castration-resistant phenotype. TMA3 (CRPC Met Heterogeneity)'s intended use is to assess the heterogeneity of molecular markers across different anatomic sites in lethal prostate cancer metastases.ConclusionsThe GAP1-UTMA project has succeeded in combining a large set of tissue specimens from 501 patients with prostate cancer with rich clinical annotation.ImpactThis resource is now available to the prostate cancer community as a tool for biomarker validation to address important unanswered clinical questions around disease progression and response to treatment.</p

Pain and the administration of analgesia: What nurses say.

Pain of moderate to severe intensity continues to be an important problem for many hospitalized patients. Nurses spend more time with patients than any other health professional group and have a key role to play in the management of patients' pain. This paper reports the findings from a series of focus group interviews which were undertaken to explore nurses' perceptions regarding pain and the administration of narcotic analgesia. Themes identified from participants' comments related to (1) the pivotal role of nurses in pain management; (2) nursing assessment and pain management decisions (3) individual factors influencing nurses' pain management decisions and (4) the influence of others on nurses' pain management decisions. These findings have implications for further research and the development of innovative educational strategies