The role of reference intervals of laboratory tests in early phase clinical research in healthy volunteers

This article discusses one of the most disputable issues in national clinical research practice in healthy volunteers. Regulatory requirements forbid to assess even minor deviations of laboratory parameters from reference intervals as not clinically significant. Authors made analysis of such requirements from positions of foreign and national guidelines of early phase clinical research and with regard to their own experience in the field. As an important part of this work, retrospective analysis of the laboratory test results data of healthy volunteers taken from several clinical trials was conducted. The aim of this analysis was to establish the rate of not clinically significant deviations from reference intervals. The results of the analysis revealed rather high rate of not clinically significant deviations of some laboratory parameters from reference intervals in volunteers with confirmed status “healthy”. Authors noted that developers of clinical trial protocols have no unified approach to generate list of necessary laboratory tests and methods of assessment of the results. Ethical and financial aspects of the problem under discussion are also touched in this article. In conclusion, authors suggest the scale of clinical significance assessment of deviations of basic laboratory parameters from reference intervals as one of the possible options of optimizing current regulatory requirements

Time-management on therapeutic dental working

Authors offer the most productive ways of time-management of the doctor for therapeutic dental working from the analysis of 30 clinical cases. Introduction in process of intensification in activity of dental office is successful time-management in the organization of the therapeutical dentist work.Авторы на примере анализа 30 клинических случаев предлагают наиболее производительные пути управления временем врача на терапевтическом стоматологическом приеме. Успешным таймменеджментом в организации работы врача — стоматолога терапевта является внедрение процесса интенсификации в деятельность стоматологического учреждения

Geotrlchous stomatitis in the dental practice

A literature review was conducted on rare mycoses of the oral mucosa in patients with immunode^ciency conditions and hematologic malignant diseases, in particular, etiopathogenetic aspects, clinical features and an approach to the treatment of rare oral mycosis - geotrlchous stomatitis were examined

Perspectives of mutual collaboration of BRICS countries in innovation sphere of enterprise activities

The article analyzes the prerequisites and reasons for the unification of BRICS countries. It considers the level of innovative development of the participating countries in the light of international ratings, and conducts a SWOT analysis of the strengths and weaknesses of BRICS countries in innovation. Today there are many works devoted also to the economic development of BRICS countries. In this regard, an important task is the need to study possible "points of contact" in the development and use of the innovative potential of BRICS countries for cooperation in this area.El artículo analiza los requisitos previos y las razones para la unificación de los países BRICS. Considera el nivel de desarrollo innovador de los países participantes a la luz de las calificaciones internacionales, y realiza un análisis FODA de las fortalezas y debilidades de los países BRICS en innovación. Hoy en día hay muchos trabajos dedicados también al desarrollo económico de los países BRICS. En este sentido, una tarea importante es la necesidad de estudiar posibles "puntos de contacto" en el desarrollo y uso del potencial innovador de los países BRICS para la cooperación mutua en esta área

Simulated Solar Microwave Radiation Blocks the Formation of Biofilms

The article presents the results of the experimental study that was devoted to determining the blocking influence of the solar microwave radiation on the process of biofilm formation in Gram-positive and Gram-negative microorganisms. The microwave generator that allows simulating microwave “splashes ” of the Sun in the frequency range (4.0- 4.3 GHz) with the controlled inten-sity of radiation (from 50 µW/sm2 to 500 µW/sm2) was used for conducting this research. It is found out that the simulated solar radiation of the microwave range blocks the formation of the extracellular matrix by the opportunistic microorganisms. The results of this study confirm the hypothesis of the evolutionary nature of the leading role of the microwave radiation of the Sun in the life processes of organisms. The technology of the exposure on the microorganisms that was used in the experiment opens up the real prospects for reducing the persistent potential of mi-croorganisms and improving the efficiency of the bacterial infections treatment

Vitamin d status during winter months among children and adolescents with cystic fibrosis living in southern Russia

The article presents the results of vitamin D tests in children with cystic fibrosis and in healthy children living in the South of Russia. The study showed the high prevalence of vitamin D deficiency and inadequate levels in patients with cystic fibrosis (86.7%). 25(OH) D level characterizing the vitamin D status decreases progressively in patients and healthy children. With regard to the above mentioned, it is significantly lower in patients with cystic fibrosis than in healthy children in all age periods. The correlation between the serum calcidiol level and the age of patients with cystic fibrosis was r = -0.44 (p = 0.015). Intake of prophylactic (500--1000 IU/day) and therapeutic (1500--3000 IU/day) doses of cholecalciferol results in a less significant increase in calcidiol levels in patients with cystic fibrosis compared with healthy children. A significantly lower 25(OH)D level was detected in patients with cystic fibrosis infected with Staph. aureus. The 25(OH)D levels are significantly lower in children with cystic fibrosis and hypocholesterolemia, than in patients with normal cholesterol levels. Risk factors for the development of severe hypovitaminosis D in children with cystic fibrosis are age, physical developmental delay, exocrine pancreatic insufficiency, presence of chronic Staph. Aureus bronchopulmonary infection. Given the conducted study, the dosage of cholecalciferol in patients with cystic fibrosis should be at least 2 times higher than that in healthy children