Features of biochemical blood analysis in children with cholelithiasis

The purpose of the study is to determine the features of biochemical blood analysis in children with cholelithiasis.Цель исследования – определить особенности биохимического анализа крови у детей с ЖКБ

Dry skin syndrom (DSS)

The aim of the study - to consider the clinical aspects of dry skin, as well as methods for moisturizing and rehabilitating the skin in accordance with the international methodological standard of dermatovenereology and cosmetology.Цель исследования - рассмотреть клинические аспекты сухости кожи, а также методы ее увлажнения и реабилитации кожных покровов в соответствии с международным методологическим стандартом дерматовенерологии и косметологии

Analysis of Microcrafters in Materials Specimens after Long-Term Exposure on ISS Surface

The "Komplast" experiment has been carried out on the ISS by the Khrunichev Space Center jointly with other Russian scientific centers since 1998. The experiment incorporates the "Komplast" cartridges on the FGB exterior, which are fitted with materials specimens and sensors. The cartridges were sent into orbit together with FGB on 20 November 1998. In March 2011, two of the cartridges were taken back from the ISS by the "Discovery" American space shuttle after being exposed in the open space for 12 years. In the framework of this experiment the subject of analysis is the effect of the space environment on the exposed specimens of various materials. This report covers the analysis results of the surface morphology of various materials taken from the "Komplast" cartridges exposed to hits of micrometeors and micronic particles of space debris. Analysis is made of microcraters of 5 to 250 mcm in specimens of polished metals and silicone comprised in the sensor for micrometeoric particles. The report represents optic and scanning electron microscope images of craters formed in the specimens by high-velocity and low-velocity particles impacting the surface. By virtue of the electronic microscope, data on composition of the substance in the craters and of the substance of the low-velocity particles are obtained. The data make it possible to differentiate the particles as the natural-origin particles or anthropogenic-origin space debris particles. Distribution of craters and low-velocity particles in the size range of 5 to 50 mcm is obtained. The data are compared with the existing models of fluxes of natural-origin and artificial-origin microparticles on the ISS orbit. Inhomogeneous particles of complicated configuration are discovered on the surface of the analyzed specimens, whose origin are not uniquely determined and are to be the subject of further study

A Study of Micro Craters in Material Samples after Long Duration Exposure on ISS Komplast Panels

The Komplast materials experiment was designed by the Khrunichev State Research and Production Space Center, together with other Russian scientific institutes, and has been carried out by Mission Control Moscow since 1998. Komplast panels fitted with material samples and sensors were located on the International Space Station (ISS) Functional Cargo Block (FGB) module exterior surface. Within the framework of this experiment, the purpose was to study the effect of the low earth orbit (LEO) environment on exposed samples of various materials. The panels were sent into orbit with the FGB when it launched on November 20, 1998.

Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Practice

Aim. This observational (non-interventional) study was aimed at obtaining data on practitioners’ commitment to prescribing rifaximin-α therapy to patients with uncomplicated diverticular disease (UDD), to assess patients’ adherence to such prescriptions, as well as to assess physicians’ and patients’ satisfaction with this drug under the conditions of outpatient practice.Materials and methods. 27 research physicians in 22 research centres located in 15 Russian cities and 250 patients participated in an open, prospective multicentre observational study. The observation lasted for 6 months with an interim assessment after 3 months. Physicians’ prescription of rifaximin-α (dose, duration of administration, number of prescribed courses) was evaluated, as well as patients’ compliance expressed as the ratio of the actual number of taken pills to the number of prescribed pills during each course according to the MMAS-4 scale. Such symptoms, as abdominal pain, constipation, diarrhea, flatulence and tenesmus were evaluated using a 4-score scale. At the end of the study, physicians’ and patients’ satisfaction with the treatment was evaluated using a 5-score scale.Results. One fifth — 52 patients (20.8%)—had received rifaximin-α therapy prior to inclusion in the study. Most frequently, rifaximin-α therapy was prescribed monthly at a dose of 400 mg 2 times a day for 7 days. 67.6% of patients received 6 courses of treatment during the study period. The proportion of patients who received more than one course of treatment over 6 months was 97.6%. During almost all treatment courses (97.5%), patients’ compliance was more than 80%. The total score of symptom intensity decreased from 5.6 at the inclusion visit, to 2.2 points at the second visit and to 0.9 points at the end of the observation. A statistically significant (p <0.05) positive dynamics was observed in relation to all evaluated symptoms (abdominal pain, constipation, diarrhea, flatulence, tenesmus). By the end of the study, 59.6% of patients and 68.8% of physicians rated the treatment results as “excellent”, 25.2% of patients and 20.4% of doctors as “good”.Conclusions. During the observation, a significant decrease in the severity of UDD symptoms, such as abdominal pain, constipation, diarrhea, flatulence and tenesmus was noted. No adverse effects associated with rifaximin-α were reported. The data obtained confirm the previously published results of randomized controlled trials on the efficacy and safety of rifaximin-α in UDD