677 research outputs found
Higher-order analytic solutions for critical cases of ballistic entry
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77179/1/AIAA-1996-3425-378.pd
First Penning-trap mass measurement in the millisecond half-life range: the exotic halo nucleus 11Li
In this letter, we report a new mass for Li using the trapping
experiment TITAN at TRIUMF's ISAC facility. This is by far the shortest-lived
nuclide, , for which a mass measurement has ever been
performed with a Penning trap. Combined with our mass measurements of
Li we derive a new two-neutron separation energy of 369.15(65) keV: a
factor of seven more precise than the best previous value. This new value is a
critical ingredient for the determination of the halo charge radius from
isotope-shift measurements. We also report results from state-of-the-art
atomic-physics calculations using the new mass and extract a new charge radius
for Li. This result is a remarkable confluence of nuclear and atomic
physics.Comment: Formatted for submission to PR
Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)
The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were investigated through a strategy based on simultaneous expression proteomics and redox proteomics determinations. Bioinformatics analysis of the proteomics data supports the view that the most critical cellular changes elicited by AF treatment consist of thioredoxin reductase inhibition, alteration of the cell redox state, impairment of the mitochondrial functions, metabolic changes associated with conversion to a glycolytic phenotype, induction of ER stress. The occurrence of the above cellular changes was extensively validated by performing direct biochemical assays. Our data are consistent with the concept that AF produces its effects through a multitarget mechanism that mainly affects the redox metabolism and the mitochondrial functions and results into severe ER stress. Results are discussed in the context of the current mechanistic knowledge existing on AF
Design and Validation of a Bifunctional Ligand Display System for Receptor Targeting
AbstractHere we developed a bacteriophage display particle designed to serve as a bifunctional entity that can target tumors while delivering an agent. We engineered a chimera phage vector containing a pIII-displayed αv integrins-targeting moiety and a pVIII-displayed streptavidin binding adaptor moiety. By using the chimeric phage particle, targeting of αv integrins on cells in culture and tumor-related blood vessels was shown through different applications, including luminescent quantum dots localization, surface plasmon resonance-based binding detection, and an in vivo tumor model. The strategy validated here will accelerate the discovery and characterization of receptor-ligand binding events in high throughput, and cell-specific delivery of diagnostics or therapeutics to organs of choice without the need for chemical conjugation
Phugoid motion for grazing-entry trajectories at near-circular speeds
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77023/1/AIAA-26742-801.pd
Intersublevel Polaron Dephasing in Self-Assembled Quantum Dots
Polaron dephasing processes are investigated in InAs/GaAs dots using
far-infrared transient four wave mixing (FWM) spectroscopy. We observe an
oscillatory behaviour in the FWM signal shortly (< 5 ps) after resonant
excitation of the lowest energy conduction band transition due to coherent
acoustic phonon generation. The subsequent single exponential decay yields long
intraband dephasing times of 90 ps. We find excellent agreement between our
measured and calculated FWM dynamics, and show that both real and virtual
acoustic phonon processes are necessary to explain the temperature dependence
of the polarization decay.Comment: 10 pages, 4 figures, submitted to Phys Rev Let
Fast detector of the ellipticity of infrared and terahertz radiation based on HgTe quantum well structures
We report a fast, room temperature detection scheme for the polarization
ellipticity of laser radiation, with a bandwidth that stretches from the
infrared to the terahertz range. The device consists of two elements, one in
front of the other, that detect the polarization ellipticity and the azimuthal
angle of the ellipse. The elements respectively utilise the circular
photogalvanic effect in a narrow gap semiconductor and the linear photogalvanic
effect in a bulk piezoelectric semiconductor. For the former we characterized
both a HgTe quantum well and bulk Te, and for the latter, bulk GaAs. In
contrast with optical methods our device is an easy to handle all-electric
approach, which we demonstrated by applying a large number of different lasers
from low power, continuous wave systems to high power, pulsed sources.Comment: 7 pages, 5 figure
The d* dibaryon in the extended quark-delocalization, color-screening model
The quark-delocalization, color-screening model, extended by inclusion of a
one-pion-exchange (OPE) tail, is applied to the study of the deuteron and the
d* dibaryon. The results show that the properties of the deuteron (an extended
object) are well reproduced, greatly improving the agreement with experimental
data as compared to our previous study (without OPE). At the same time, the
mass and decay width of the d* (a compact object) are, as expected, not altered
significantly.Comment: 9 pages, no figures, LaTeX, subm. to Phys. Rev.
Visible light-induced switching of soft matter materials properties based on thioindigo photoswitches
Thioindigos are visible light responsive photoswitches with excellent spatial control over the conformational change between their trans- and cis- isomers. However, they possess limited solubility in all conventional organic solvents and polymers, hindering their application in soft matter materials. Herein, we introduce a strategy for the covalent insertion of thioindigo units into polymer main chains, enabling thioindigos to function within crosslinked polymeric hydrogels. We overcome their solubility issue by developing a thioindigo bismethacrylate linker able to undergo radical initiated thiol-ene reaction for step-growth polymerization, generating indigo-containing polymers. The optimal wavelength for the reversible trans-/cis- isomerisation of thioindigo was elucidated by constructing a detailed photochemical action plot of their switching efficiencies at a wide range of monochromatic wavelengths. Critically, indigo-containing polymers display significant photoswitching of the materials’ optical and physical properties in organic solvents and water. Furthermore, the photoswitching of thioindigo within crosslinked structures enables visible light induced modulation of the hydrogel stiffness. Both the thioindigo-containing hydrogels and photoswitching processes are non-toxic to cells, thus offering opportunities for advanced applications in soft matter materials and biology-related research
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