Influence of health resort treatment on the level of systemic inflammation in patients after new coronavirus infection

Background. Low-grade inflammation is currently one of the main risk factors for the development of adverse events in the cardiovascular system, including death from cardiovascular diseases or their complications that cause mortality in the postCOVID period.The aim of the study. To assess the impact of health resort treatment in the conditions of the Southern Coast of Crimea on clinical and functional parameters, as well as on the level of systemic inflammation in patients after a new coronavirus infection.Materials and methods. The study included 67 patients (54.9 ± 9.05 years) in the post-COVID period who underwent health resort treatment at the I.M. Sechenov Academic Research Institute of Physical Treatment Methods, Medical Climatology and Rehabilitation. Methods of health resort treatment included climatic treatment on the Southern Coast of Crimea, therapeutic breathing exercises, terrainkur, and various methods of respiratory therapy. In all patients, the study of the C-reactive protein (CRP) in peripheral blood upon admission and at discharge was carried out.Results. Despite a statistically significant improvement in most clinical and functional parameters, the level of CRP and the number of leukocytes and their subpopulations in peripheral blood in patients who underwent health resort treatment did not differ significantly (p > 0.05) from the baseline values obtained upon admission at the I.M. Sechenov Academic Research Institute of Physical Treatment Methods, Medical Climatology and Rehabilitation. The CRP index upon admission and at discharge corresponded to the lower limit of the interval specific for low-grade inflammation (from 3 to 10 mg/l).Conclusion. Our results indicate the lack of effectiveness of the presented plan of health resort treatment in the correction of low-intensity inflammation, as well as the necessity for deeper scientific research in the direction of studying the mechanisms of low-grade inflammation development and the methods of its management

Population genomics of speciation and admixture

The application of population genomics to the understanding of speciation has led to the emerging field of speciation genomics. This has brought new insight into how divergence builds up within the genome during speciation and is also revealing the extent to which species can continue to exchange genetic material despite reproductive barriers. It is also providing powerful new approaches for linking genotype to phenotype in admixed populations. In this chapter, we give an overview of some of the methods that have been used and some of the novel insights gained. We also outline some of the pitfalls of the most commonly used methods and possible problems with interpretation of the results

CURRENT ISSUES OF REHABILITATION OF PATIENTS WITH RESPIRATORY DISEASES АТ CLIMATIC RESORT

Respiratory diseases are a serious health problem due to their wide prevalence, not always adequate treatment, sufficiently high probability of developing complications, and frequent formation of disability. One of the important tasks of the development of rehabilitation medicine in the resorts of Russia is to improve programs for the recovery treatment and prevention of respiratory diseases. The spread around the world of a new coronavirus infection, with the most frequent lung damage, has set a new task – the rehabilitation of patients who have suffered pneumonia caused by COVID-19. It is necessary to develop regional standards for sanatorium-resort medical rehabilitation, which made it possible to rationally use the recreational potential of the coastal climatic resorts of Crimea for patients with various respiratory diseases

CLUSTER ANALYSIS CLASSIFICATION OF ASTHMATIC PATHOLOGIC MANIFESTATIONS DURING STAY AT THE RESORT

The objective of the study: to classify the pathologic manifestations of asthma using cluster analysis and based on the obtained clusters to substantiate the identification of asthma phenotypes while being at the resort. Subjects and methods. 300 asthma patients who arrived to Yalta for treatment at the resort were examined. Of those with persisting asthma, 55 (18.33%) patients had a mild severity of the disease, 205 (68.33%) had moderate severity and 27 (9%) had the advanced severity of the disease. 13 (4.33%) were found to have intermittent asthma. 42 (14%) patients had the controlled course of asthma, 60 (20%) had it partially controlled, and 198 (66%) patients suffered from the uncontrolled asthma. The cluster analysis was used to classify the manifestations of asthma at the resort. Results. 105 rates were analyzed in 300 asthma patients, who had treatment at the resort. The structure consisting of 7 clusters was formed through cluster analysis. 23 rates had high values of inter-cluster dispersion describing the clinical and functional state of asthma patients, which could be considered as separate clusters. Each cluster had certain disorders of clinical and functional state of asthma patients, typical of this cluster only, thus the generated structure of clusters could be considered to be a classification of asthmatic pathologic manifestations, i.e. asthmatic phenotypes during the stay at the resort. Conclusions. 7 asthmatic phenotypes typical of staying at the resort were identified, characterized by different pathogenetic manifestations, which could be useful when planning sanatorium-resort care for such patients