Children in Trouble with the Law and the United Nations Convention on the Rights of the Child

Children in trouble with the law are the focus of much research in the US, but when the scope broadens to include these children across the world, few studies can be found. The United Nations (UN) Convention on the Rights of the Child (CRC) articulates a set of universal rights for children. For children in trouble with the law, there are seven articulated rights across Articles 37 and 40; these are: protection against cruel, inhuman and degrading treatment or punishment; the right not to be detained in jails or prisons with adult convicts; the right to maintain contact with family members; protection against capital punishment and life without the possibility of release punishments; the right to an attorney or legal counsel; the right to a minimum age of criminal responsibility set by the government; and the right to a fair and speedy trial. This study used CRC country reports, NGO supplemental reports, and Committee on the Rights of the Child’s responses to the other reports to address the question, “What are the global range and patterns of national practices regarding children in trouble with the law?” Qualitative content analysis revealed that countries’ overall compliance ranged from high-medium to low-medium, and that there is wide variation in the discussion of each of the 7 rights individually. Findings are connected to the literature on human rights treaty compliance, global children’s rights, and research on Articles 37 and 40 of the CRC

Plea Bargains: What to Do When the Prosecutor Says No

A common misconception of the American criminal justice system is the belief that an accused may only be convicted by a jury of his peers after a trial in which his defense lawyer and the prosecutor sharply contest his guilt. In a majority of cases, however, this scenario never occurs. Instead, the prosecution and defense usually make a deal; that is, the defendant agrees to plead guilty and the prosecutor agrees to make concessions in return. One study has estimated that guilty pleas account for ninety percent of all convictions and that most of these pleas are the result of plea bargaining. In short, plea bargaining has become an important part of our criminal justice system. Despite its advantages, plea bargaining is not without its critics. One critic has written that when plea negotiations occur the rule of law is invariably sacrificed to the rule of convenience.” Furthermore, plea bargaining may create a danger that defendants will be deterred from exercising their constitutional rights and, in some cases, may even induce innocent defendants to plead guilty. Other critics maintain that plea bargaining compromises the prosecutor\u27s duty to enforce the law. Nevertheless, courts could not handle the workload if all criminal defendants insisted on a trial. In light of this fact, plea bargaining is a bureaucratic necessity which has become indispensible to the administration of the present criminal justice system. The practice of plea bargaining was expressly sanctioned by the United States Supreme Court in Santobello v. New York. Many issues, however, remain unresolved. This comment will examine the remedies available to a defendant who, having entered a negotiated plea, subsequently alleges that the prosecutor breached his part of the bargain. In this context, the relevant questions that will be examined are: 1) Was there in fact a promise? 2) Was the promise broken? 3) Under what theory may relief be given? and 4) What type of relief is appropriate

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria

Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation. They differed in several respects: electronmicroscopic appearance, phospholipid and cytochrome contents, electrophoretic behaviour of proteins and enzymatic activities. Three types of inner membrane fractions were isolated. The first type is characterized by a high activity of metal chelatase, low activities of succinate-cytochrome c reductase and of glycerolphosphate dehydrogenase, as well as by a high phospholipid content and low contents of cytochromes aa3 and b. The second type displays maximal activities of glycerolphosphate dehydrogenase and metal chelatase, but contains relatively little cytochromes and has low succinate-cytochrome c reductase activity. The third type exhibits highest succinate-cytochrome c reductase activity, a high metal chelatase activity and highest cytochrome contents. However, this fraction was low in both glycerolphosphate dehydrogenase activity and phospholipid content. This fraction was also richest in the following enzyme activities: cytochrome oxidase, oligomycin-sensitive ATPase, proline oxidase, 3-hydroxybutyrate dehydrogenase and rotenone-sensitive NADH-cytochrome c reductase. Amino acid incorporation in vitro and in vivo in the presence of cycloheximide occurs predominantly into inner membrane fractions from the second type. These data suggest that the inner membrane is composed of differently organized parts, and that polypeptides synthesized by mitochondrial ribosomes are integrated into specific parts of the inner membrane

Update on the management of chronic eczema: new approaches and emerging treatment options

Atopic dermatitis (AD) is a common disease with worldwide prevalence, affecting up to 20% of children and 3% of adults. Recent evidence regarding pathogenesis has implicated epidermal barrier defects deriving from filagrin mutations with resulting secondary inflammation. In this report, the authors comprehensively review the literature on atopic dermatitis therapy, including topical and systemic options. Most cases of AD will benefit from emollients to enhance the barrier function of skin. Topical corticosteroids are first-line therapy for most cases of AD. Topical calcineurin inhibitors (tacrolimus ointment, pimecrolimus cream) are considered second line therapy. Several novel barrier-enhancing prescription creams are also available. Moderate to severe cases inadequately controlled with topical therapy may require phototherapy or systemic therapy. The most commonly employed phototherapy modalites are narrow-band UVB, broadband UVB, and UVA1. Traditional systemic therapies include short-term corticosteroids, cyclosporine (considered to be the gold standard), methotrexate, azathioprine, mycophenolate mofetil, and most recently leflunamide. Biologic therapies include recombinant monoclonal antibodies acting on the immunoglobulin E / interleukin-5 pathway (omalizumab, mepolizumab), acting as tumor necrosis factor-α inhibitors (infliximab, etanercept, adalimumab), and acting as T-cell (alefacept) and B-cell (rituxumab) inhibitors, as well as interferon γ and intravenous immunoglobulin. Efficacy, safety, and tolerability are reviewed for each medication

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5′monophosphate–activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarity and growth control through PAR-1 and AMPK, respectively. However, the genetic analysis of LKB1–AMPK signaling in vertebrates has been complicated by the existence of multiple redundant AMPK subunits. We describe the identification of mutations in the single Drosophila melanogaster AMPK catalytic subunit AMPKα. Surprisingly, ampkα mutant epithelial cells lose their polarity and overproliferate under energetic stress. LKB1 is required in vivo for AMPK activation, and lkb1 mutations cause similar energetic stress–dependent phenotypes to ampkα mutations. Furthermore, lkb1 phenotypes are rescued by a phosphomimetic version of AMPKα. Thus, LKB1 signals through AMPK to coordinate epithelial polarity and proliferation with cellular energy status, and this might underlie the tumor suppressor function of LKB1

Oocyte expression with injection of purified T7 RNA polymerase.

International audienceThe Xenopus oocyte is a widely used system for protein expression. Investigators have had the choice between two different techniques: injection into the cytoplasm of in vitro transcribed complementary RNA (cRNA) or injection into the nucleus of complementary DNA (cDNA). We report on a third expression technique that is based on the combined injection of cDNA and purified T7 RNA polymerase directly into the cytoplasm of oocytes

Compassionate pedagogy: the ethics of care in early childhood professionalism

This paper builds upon an earlier attempt (Taggart, 2011) to articulate a rationale for professional training in early childhood education and care (ECEC) which is ethical as opposed to one which is purely instrumental or rooted in a patriarchal notion of women’s supposed unique suitability. The argument proposes that a feminist approach to ethics, as both socially critical and psychologically affective or flexible, has a particular relevance to professional identity in ECEC. In particular, compassion, as a concept which has both sociological and psychological connotations, foregrounds the ethical dimension of the work whilst overcoming false dichotomies between discourses of ‘children’s rights’ and ‘care’. The implications for the training and professional identity of practitioners are discussed