1,069 research outputs found
Many-body large polaron optical conductivity in SrTiNbO
Recent experimental data on the optical conductivity of niobium doped
SrTiO are interpreted in terms of a gas of large polarons with effective
coupling constant . The {theoretical approach takes into
account} many-body effects, the electron-phonon interaction with multiple
LO-phonon branches, and the degeneracy and the anisotropy of the Ti t
conduction band. {Based on the Fr\"{o}hlich interaction, the many-body
large-polaron theory} provides an interpretation for the essential
characteristics, except -- interestingly -- for the unexpectedly large
intensity of a peak at meV, of the observed optical conductivity
spectra of SrTiNbO \textit{without} any adjustment of
material parameters.Comment: to appear in Phys. Rev.
Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.
At the beginning of the third week of pregnancy, mouse fetuses with targeted disruption of their paternally-transmitted insulin-like growth factor 2 gene placental-specific transcripts have growth-restricted placentas but normal body weights due to upregulated placental nutrient transport. We assessed whether increased placental glucose transport rates were associated with raised maternal glucose concentrations by performing intraperitoneal glucose tolerance tests (ipGTT) in pregnant mice carrying knockout pups and comparing them with mice carrying genotype-matched phenotypically wild type pups. Mean ± SD body weights of affected pups were 95 ± 8% of control values at e16 and 73 ± 7% at e18. There were no differences in areas under the maternal ipGTT curves at either e16 (mean ± SD being 99.0 ± 9.1% of control values; P = .9) or e18 (91.4 ± 13.4%; P = .3), suggesting that effects on transplacental glucose transport in these mice are not mediated through changes in maternal glucose concentrations
A global disorder of imprinting in the human female germ line
Imprinted genes are expressed differently depending on whether they are carried by a chromosome of maternal or paternal origin. Correct imprinting is established by germline-specific modifications; failure of this process underlies several inherited human syndromes. All these imprinting control defects are cis-acting, disrupting establishment or maintenance of allele-specific epigenetic modifications across one contiguous segment of the genome. In contrast, we report here an inherited global imprinting defect. This recessive maternal-effect mutation disrupts the specification of imprints at multiple, non-contiguous loci, with the result that genes normally carrying a maternal methylation imprint assume a paternal epigenetic pattern on the maternal allele. The resulting conception is phenotypically indistinguishable from an androgenetic complete hydatidiform mole, in which abnormal extra-embryonic tissue proliferates while development of the embryo is absent or nearly so. This disorder offers a genetic route to the identification of trans-acting oocyte factors that mediate maternal imprint establishment
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Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13.
OBJECTIVE: We have hypothesized that variation in imprinted growth-promoting fetal genes may affect maternal glucose concentrations in pregnancy. To test this hypothesis we evaluated the effects of fetal disruption of murine H19(Delta13) on maternal glucose concentrations in pregnancy. RESEARCH DESIGN AND METHODS: Experimental mice were pregnant females that had inherited the disrupted H19(Delta13) from their fathers and were therefore phenotypically wild type due to imprinting; approximately half of their litters were null for H19(Delta13) through maternal inheritance of the disrupted gene. In control mice approximately half the litter paternally inherited the disrupted H19(Delta13), so the pups were either genetically wild type or phenotypically wild type due to imprinting. Blood glucose concentrations were assessed by intraperitoneal glucose tolerance tests on days 1, 16, and 18 of pregnancy. RESULTS: There were no differences in the glucose concentrations of control and experimental pregnant mice at day 1. However, at day 16 mothers carrying H19(Delta13)-null pups had a significantly higher area under the glucose tolerance test curves than controls (1,845 +/- 378 vs. 1,386 +/- 107 mmol * min * l(-1) [P = 0.01]) in association with increasing pregnancy-related insulin resistance. Although this difference lessened toward term, overall, mothers of maternally inherited H19(Delta13) mutants had significantly higher glucose concentrations during the last trimester (1,602 +/- 321 [n = 17] vs. 1,359 +/- 147 [n = 18] mmol * min * l(-1) [P = 0.009]). CONCLUSIONS: This study provides evidence that maternal glucose concentrations in pregnant mice can be affected by targeted disruption of fetal H19(Delta13). This implies that variable fetal IGF2 expression could affect risk for gestational diabetes
Time evolution of the Rabi Hamiltonian from the unexcited vacuum
The Rabi Hamiltonian describes a single mode of electromagnetic radiation
interacting with a two-level atom. Using the coupled cluster method, we
investigate the time evolution of this system from an initially empty field
mode and an unexcited atom. We give results for the atomic inversion and field
occupation, and find that the virtual processes cause the field to be squeezed.
No anti-bunching occurs.Comment: 25 pages, 8 figures, RevTe
Development of an approximate method for quantum optical models and their pseudo-Hermicity
An approximate method is suggested to obtain analytical expressions for the
eigenvalues and eigenfunctions of the some quantum optical models. The method
is based on the Lie-type transformation of the Hamiltonians. In a particular
case it is demonstrated that Jahn-Teller Hamiltonian can
easily be solved within the framework of the suggested approximation. The
method presented here is conceptually simple and can easily be extended to the
other quantum optical models. We also show that for a purely imaginary coupling
the Hamiltonian becomes non-Hermitian but -symmetric. Possible generalization of this approach is outlined.Comment: Paper prepared fo the "3rd International Workshop on Pseudo-Hermitian
Hamiltonians in Quantum Physics" June 2005 Istanbul. To be published in
Czechoslovak Journal of Physic
Conductivity of CuO-Chains: Disorder versus Electron-Phonon Coupling
The optical conductivity of the CuO-chains, a subsystem of the 1-2-3
materials, is dominated by a broad peak in the mid-infrared (eV), and a slowly falling high-frequency tail. The 1D --model is
proposed as the relevant low-energy Hamiltonian describing the intrinsic
electronic structure of the CuO-chains. However, due to charge-spin
decoupling, this model alone cannot reproduce the observed \sw. We consider
two additional scattering mechanisms: (i) Disregarding the not so crucial spin
degrees of freedom, the inclusion of strong potential disorder yields excellent
agreement with experiment, but suffers from the unreasonable value of the
disorder strength necessary for the fit. (ii) Moderately strong polaronic
electron-phonon coupling to the mode involving Cu(1)-O(4) stretching, can be
modeled within a 1D Holstein Hamiltonian of spinless fermions. Using a
variational approximation for the phonon Hilbert space, we diagonalize the
Hamiltonian exactly on finite lattices. As a result of the experimental hole
density , the chains can exhibit strong charge-density-wave (CDW)
correlations, driven by phonon-mediated polaron-polaron interactions. In the
vicinity of half filling, charge motion is identified as arising from moving
domain walls, \ie defects in the CDW. Incorporating the effect of vacancy
disorder by choosing open boundary conditions, good agreement with the
experimental spectra is found. In particular, a high-frequency tail arises as a
consequence of the polaron-polaron interactions.Comment: 42 pages, ETH-TH/93-31 (Postscript
Polaronic optical absorption in electron-doped and hole-doped cuprates
Polaronic features similar to those previously observed in the photoinduced
spectra of cuprates have been detected in the reflectivity spectra of
chemically doped parent compounds of high-critical-temperature superconductors,
both -type and -type. In NdCuO these features, whose
intensities depend both on doping and temperature, include local vibrational
modes in the far infrared and a broad band centered at 1000 cm.
The latter band is produced by the overtones of two (or three) local modes and
is well described in terms of a small-polaron model, with a binding energy of
about 500 cm. Most of the above infrared features are shown to survive
in the metallic phase of NdCeCu0, BiSrCuO, and
YBaCuO, where they appear as extra-Drude peaks. The occurrence
of polarons is attributed to local modes strongly coupled to carriers, as shown
by a comparison with tunneling results.Comment: File latex, 31 p., submitted to Physical Review B. Figures may be
faxed upon reques
Infrared response of ordered polarons in layered perovskites
We report on the infrared absorption spectra of three oxides where charged
superlattices have been recently observed in diffraction experiments. In
LaSrNiO, polaron localization is found to suppress the
low-energy conductivity through the opening of a gap and to split the
- vibrational manifold of the oxygen octahedra. Similar effects
are detected in SrLaMnO and in LaNiO, with
peculiar differences related to the type of charge ordering.Comment: File latex, 11 p. + 3 Figures, to appear on Phys. Rev. B (Rapid
Commun.), 1 Oct. 1996. The figures will be faxed upon request.
E-mail:[email protected] Fax: +39-6-446315
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila. However, it has not been reported to mediate heterochromatin formation or heritable silencing for endogenous mammalian genes. Herein, we show that SIRT1 localizes to promoters of several aberrantly silenced tumor suppressor genes (TSGs) in which 5′ CpG islands are densely hypermethylated, but not to these same promoters in cell lines in which the promoters are not hypermethylated and the genes are expressed. Heretofore, only type I and II HDACs, through deactylation of lysines 9 and 14 of histone H3 (H3-K9 and H3-K14, respectively), had been tied to the above TSG silencing. However, inhibition of these enzymes alone fails to re-activate the genes unless DNA methylation is first inhibited. In contrast, inhibition of SIRT1 by pharmacologic, dominant negative, and siRNA (small interfering RNA)–mediated inhibition in breast and colon cancer cells causes increased H4-K16 and H3-K9 acetylation at endogenous promoters and gene re-expression despite full retention of promoter DNA hypermethylation. Furthermore, SIRT1 inhibition affects key phenotypic aspects of cancer cells. We thus have identified a new component of epigenetic TSG silencing that may potentially link some epigenetic changes associated with aging with those found in cancer, and provide new directions for therapeutically targeting these important genes for re-expression
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