Gravitational Wave Background from Phantom Superinflation

Recently, the early superinflation driven by phantom field has been proposed and studied. The detection of primordial gravitational wave is an important means to know the state of very early universe. In this brief report we discuss in detail the gravitational wave background excited during the phantom superinflation.Comment: 3 pages, 2 eps figures, to be published in PRD, revised with published version, refs. adde

Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair

Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe noncell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair. SIGNIFICANCE STATEMENT Lack of robust remyelination represents one of the major barriers to recovery of neurological functions in disease or following injury in many disorders of the nervous system. Here we show that the adhesion class G protein-coupled receptor (GPCR) Gpr126/Adgrg6 is required for remyelination, macrophage recruitment, and axon regeneration following nerve injury. At least 30% of all approved drugs target GPCRs; thus, Gpr126 represents an attractive potential target to stimulate repair in myelin disease or following nerve injury

The Bouncing Jet: A Newtonian Liquid Rebounding off a Free Surface

We find that a liquid jet can bounce off a bath of the same liquid if the bath is moving horizontally with respect to the jet. Previous observations of jets rebounding off a bath (e.g. Kaye effect) have been reported only for non-Newtonian fluids, while we observe bouncing jets in a variety of Newtonian fluids, including mineral oil poured by hand. A thin layer of air separates the bouncing jet from the bath, and the relative motion replenishes the film of air. Jets with one or two bounces are stable for a range of viscosity, jet flow rate and velocity, and bath velocity. The bouncing phenomenon exhibits hysteresis and multiple steady states.Comment: 9 pages, 7 figures. submitted to Physical Review

Disease-Associated Mutations Prevent GPR56-Collagen III Interaction

GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Mutations in GPR56 cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Using the N-terminal fragment of GPR56 (GPR56N) as a probe, we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain. In this report, we discover a new functional domain in GPR56N, the ligand binding domain. This domain contains four disease-associated mutations and two N-glycosylation sites. Our study reveals that although glycosylation is not required for ligand binding, each of the four disease-associated mutations completely abolish the ligand binding ability of GPR56. Our data indicates that these four single missense mutations cause BFPP mostly by abolishing the ability of GPR56 to bind to its ligand, collagen III, in addition to affecting GPR56 protein surface expression as previously shown

Spectrum of Curvature Perturbation of Multi-field Inflation with Small-Field Potential

In this paper, we have studied the spectrum of curvature perturbation of multi-field inflation with general small-field potential. We assume that the isocurvature perturbation may be neglected, and by using the Sasaki-Stewart formalism, we found that the spectrum may be redder or bluer than of its corresponding single field. The result depends upon the values of fields and their effective masses at the horizon-crossing time. We discuss the relevant cases.Comment: 8 pages, no figure, to publish in JCA

Inflationary Attractor in Braneworld Scenario

We demonstrate the attractor behavior of inflation driven by a scalar field or a tachyon field in the context of recently proposed four-dimensional effective gravity induced on the world-volume of a three-brane in five-dimensional Einstein gravity, and we obtain a set of exact inflationary solutions. Phase portraits indicate that an initial kinetic term decays rapidly and it does not prevent the onset of inflation. The trajectories more rapidly reach the slow-roll curve than in the standard cosmology.Comment: 7 pages, 8 figures, RevTeX, to appear in Phys. Rev. D69 (2004

Assisted Tachyonic Inflation

The model of inflation with a single tachyon field generates larger anisotropy and has difficulties in describing the formation of the Universe . In this paper we consider a model with multi tachyon fields and study the assisted inflationary solution. Our results show that this model satisfies the observation.Comment: 5 pages, no figures, a revised version and reference adde

Predicting the Digestible Energy of Rapeseed Meal from Its Chemical Composition in Growing-finishing Pigs

Two experiments were conducted to establish a digestible energy (DE) content prediction model of rapeseed meal for growing-finishing pig based on rapeseed meal’s chemical composition. In experiment 1, observed linear relationships between the determined DE content of 22 rapeseed meal calibration samples and proximate nutrients, gross energy (GE) and neutral detergent fiber (NDF) were used to develop the DE prediction model. In experiment 2, 4 samples of rapeseed meal selected at random from the primary rapeseed growing regions of China were used for testing the accuracy of DE prediction models. The results indicated that the DE was negatively correlated with NDF (r = −0.86) and acid detergent fiber (ADF) (r = −0.73) contents, and moderately correlated with gross energy (GE; r = 0.56) content in rapeseed meal calibration samples. In contrast, no significant correlations were found for crude protein, ether extract, crude fiber and ash contents. According to the regression analysis, NDF or both NDF and GE were found to be useful for the DE prediction models. Two prediction models: DE = 16.775−0.147×NDF (R2 = 0.73) and DE = 11.848−0.131×NDF+0.231×GE (R2 = 0.76) were obtained. The maximum absolute difference between the in vivo DE determinations and the predicted DE values was 0.62 MJ/kg and the relative difference was 5.21%. Therefore, it was concluded that, for growing-finishing pigs, these two prediction models could be used to predict the DE content of rapeseed meal with acceptable accuracy