RMD-QOSM: The NSIS Quality-of-Service Model for Resource Management in Diffserv

This document describes a Next Steps in Signaling (NSIS) Quality-of- Service (QoS) Model for networks that use the Resource Management in Diffserv (RMD) concept. RMD is a technique for adding admission control and preemption function to Differentiated Services (Diffserv) networks. The RMD QoS Model allows devices external to the RMD network to signal reservation requests to Edge nodes in the RMD network. The RMD Ingress Edge nodes classify the incoming flows into traffic classes and signals resource requests for the corresponding traffic class along the data path to the Egress Edge nodes for each flow. Egress nodes reconstitute the original requests and continue forwarding them along the data path towards the final destination. In addition, RMD defines notification functions to indicate overload situations within the domain to the Edge nodes

Assessment of Verbal and Nonverbal Memory and Learning in Abstinent Alcoholics

Neuropsychological performance was measured in chronic alcoholics who maintained abstinence for at least six months and with matched controls. Specifically, measures of verbal memory were assessed utilizing the Rey Auditory Verbal Learning Test (RAVLT) and measures of nonverbal memory with the Rey Osterreith Complex Figure Test (ROCF) and a new measure, the Poreh Nonverbal Memory Test (PNMT). In addition, both the RAVLT and the PNMT provide a measure of operationalized learning, as they are multi-trial tasks utilizing five trials to assess recall in each trial. Verbal memory includes the ability to encode, store and retrieve information for words, language and verbal stimuli. Nonverbal memory reflects the ability to encode, store and retrieve information that is visual and spatial in nature. It is devoid of verbal components and includes abstract designs or nonsense figures. Currently, there are questions as to the validity of many nonverbal memory measures because they allow for sub-vocalization of the tasks thereby utilizing verbal mediation (Wisniewski, Wendling, Manning & Steinhoff, 2012). The present study assessed for differences in verbal and nonverbal memory in abstinent alcoholics and predicted that they would perform more poorly on nonverbal measures while verbal memory would remain intact. Additionally, a comparison of learning curves was examined for each group. Finally, the PNMT was validated by correlating with a current neuropsychological assessment of memory and learning, the RAVLT, and a nonverbal neuropsychological assessment, the ROCF. Results indicated that the abstinent alcoholics differed significantly in nonverbal measurements depending upon the complexity of the tasks. Concerning verbal tasks, there was no significant difference in results across the groups. However, the length of alcohol dependence did significantly predict performance on the RAVLT recognition task indicating possible frontal lobe deficits and disordered recall. Correlational analyses indicate that the utilit

Assessment of Verbal and Nonverbal Memory and Learning in Abstinent Alcoholics

Neuropsychological performance was measured in chronic alcoholics who maintained abstinence for at least six months and with matched controls. Specifically, measures of verbal memory were assessed utilizing the Rey Auditory Verbal Learning Test (RAVLT) and measures of nonverbal memory with the Rey Osterreith Complex Figure Test (ROCF) and a new measure, the Poreh Nonverbal Memory Test (PNMT). In addition, both the RAVLT and the PNMT provide a measure of operationalized learning, as they are multi-trial tasks utilizing five trials to assess recall in each trial. Verbal memory includes the ability to encode, store and retrieve information for words, language and verbal stimuli. Nonverbal memory reflects the ability to encode, store and retrieve information that is visual and spatial in nature. It is devoid of verbal components and includes abstract designs or nonsense figures. Currently, there are questions as to the validity of many nonverbal memory measures because they allow for sub-vocalization of the tasks thereby utilizing verbal mediation (Wisniewski, Wendling, Manning & Steinhoff, 2012). The present study assessed for differences in verbal and nonverbal memory in abstinent alcoholics and predicted that they would perform more poorly on nonverbal measures while verbal memory would remain intact. Additionally, a comparison of learning curves was examined for each group. Finally, the PNMT was validated by correlating with a current neuropsychological assessment of memory and learning, the RAVLT, and a nonverbal neuropsychological assessment, the ROCF. Results indicated that the abstinent alcoholics differed significantly in nonverbal measurements depending upon the complexity of the tasks. Concerning verbal tasks, there was no significant difference in results across the groups. However, the length of alcohol dependence did significantly predict performance on the RAVLT recognition task indicating possible frontal lobe deficits and disordered recall. Correlational analyses indicate that the utilit

Professional Behavior in Physical Therapist Educational Programs: Perspectives of Selected Senior Faculty

Purpose: The purpose of this study was to analyze how selected senior instructors in physical therapist educational programs define and seek to impart information on professional behavior. Methods: A qualitative case study approach was used to gather data from eight instructors teaching in four physical therapist educational programs in a selected region. Each interview was analyzed as an individual case study, followed by a cross case analysis to identify common themes. Results: Interpretational analysis using a process of constant comparison revealed nine common themes: 1) Instructors found it difficult to broadly define professional behavior. 2) Instructors expect students to be on time. 3) Instructors expect students to speak and act with courtesy and respect. 4) Instructors expect students to communicate appropriately. 5) Instructors expect students to dress appropriately. 6) Instructors expect students to participate in class. 7) Instructors consciously model professional behavior as a way to communicate their expectations. 8) Instructors give instructions and provide students with feedback about professional behavior. 9) Instructors do not attach a specific grade to professional behavior. Conclusions: Although instructors indicated a lack of confidence in consistency regarding professional behavior expectations, the themes that emerged in this study fit within existing descriptions of professional behavior for clinical physical therapists. Instructor perceptions of strategies for conveying information about professional behavior to students were consistent with existing literature on modeling and explicit teaching

Virus Sharing, Genetic Sequencing, and Global Health Security

The WHO’s Pandemic Influenza Preparedness (PIP) Framework was a milestone global agreement designed to promote the international sharing of biological samples to develop vaccines, while that ensuring poorer countries would have access to those vaccines. Since the PIP Framework was negotiated, scientists have developed the capacity to use genetic sequencing data (GSD) to develop synthetic viruses rapidly for product development of life-saving technologies in a time-sensitive global emergency—threatening to unravel the Framework. Access to GSD may also have major implications for biosecurity, biosafety, and intellectual property (IP). By rendering the physical transfer of viruses antiquated, GSD may also undermine the effectiveness of the PIP Framework itself, with disproportionate impacts on poorer countries. We examine the changes that need to be made to the PIP Framework to address the growing likelihood that GSD might be shared instead of physical virus samples. We also propose that the international community harness this opportunity to expand the scope of the PIP Framework beyond only influenza viruses with pandemic potential. In light of non-influenza pandemic threats such as the Middle East Respiratory Syndrome (MERS) and Ebola, we call for an international agreement on the sharing of the benefits of research – such as vaccines and treatments – for other infectious diseases to ensure not only a more secure and healthy world, but also a more just world, for humanity

Pressure-Induced Effects on the Structure of the FeSe Superconductor

A polycrystalline sample of FeSe, which adopts the tetragonal PbO-type structure (P4/nmm) at room temperature, has been prepared using solid state reaction. We have investigated pressure-induced structural changes in tetragonal FeSe at varying hydrostatic pressures up to 0.6 GPa in the orthorhombic (T = 50 K) and tetragonal (T = 190 K) phases using high resolution neutron powder diffraction. We report that the structure is quite compressible with a Bulk modulus around 31 GPa to 33 GPa and that the pressure response is anisotropic with a larger compressibility along the c-axis. Key bond angles of the SeFe4 pyramids and FeSe4 tetrahedra are also determined as a function of pressure

Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index. An observational study of 335 046 UK Biobank participants

Background There is growing recognition that recent global increases in obesity are the product of a complex interplay between genetic and environmental factors. However, in gene-environment studies of obesity, ‘environment’ usually refers to individual behavioural factors that influence energy balance, whereas more upstream environmental factors are overlooked. We examined gene-environment interactions between genetic risk of obesity and two neighbourhood characteristics likely to be associated with obesity (proximity to takeaway/ fast-food outlets and availability of physical activity facilities). Methods We used data from 335 046 adults aged 40–70 in the UK Biobank cohort to conduct a populationbased cross-sectional study of interactions between neighbourhood characteristics and genetic risk of obesity, in relation to body mass index (BMI). Proximity to a fast-food outlet was defined as distance from home address to nearest takeaway/fast-food outlet, and availability of physical activity facilities as the number of formal physical activity facilities within 1 km of home address. Genetic risk of obesity was operationalised by weighted Genetic Risk Scores of 91 or 69 single nucleotide polymorphisms (SNP), and by six individual SNPs considered separately. Multivariable, mixed-effects models with product terms for the gene-environment interactions were estimated. Results After accounting for likely confounding, the association between proximity to takeaway/fast-food outlets and BMI was stronger among those at increased genetic risk of obesity, with evidence of an interaction with polygenic risk scores (p=0.018 and p=0.028 for 69- SNP and 91-SNP scores, respectively) and in particular with a SNP linked to MC4R (p=0.009), a gene known to regulate food intake. We found very little evidence of geneenvironment interaction for the availability of physical activity facilities. Conclusions Individuals at an increased genetic risk of obesity may be more sensitive to exposure to the local fast-food environment. Ensuring that neighbourhood residential environments are designed to promote a healthy weight may be particularly important for those with greater genetic susceptibility to obesity

High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age

Following a severe outbreak of clinical scrapie in 2006–2007, a large dairy goat herd was culled and 200 animals were selected for post-mortem examinations in order to ascertain the prevalence of infection, the effect of age, breed and PRNP genotype on the susceptibility to scrapie, the tissue distribution of diseaseassociated PrP (PrP$^{\rm d}$), and the comparative efficiency of different diagnostic methods. As determined by immunohistochemical (IHC) examinations with Bar224 PrP antibody, the prevalence of preclinical infection was very high (72/200; 36.0%), with most infected animals being positive for PrP$^{\rm d}$ in lymphoreticular system (LRS) tissues (68/72; 94.4%) compared to those that were positive in brain samples (38/72; 52.8%). The retropharyngeal lymph node and the palatine tonsil showed the highest frequency of PrP$^{\rm d}$ accumulation (87.3% and 84.5%, respectively), while the recto-anal mucosa-associated lymphoid tissue (RAMALT) was positive in only 30 (41.7%) of the infected goats. However, the efficiency of rectal and palatine tonsil biopsies taken shortly before necropsy was similar. The probability of brain and RAMALT being positive directly correlated with the spread of PrP$^{\rm d}$ within the LRS. The prevalence of infection was influenced by PRNP genetics at codon 142 and by the age of the goats: methionine carriers older than 60 months showed a much lower prevalence of infection (12/78; 15.4%) than those younger than 60 months (20/42; 47.6%); these last showed prevalence values similar to isoleucine homozygotes of any age (40/80; 50.0%). Two of seven goats with definite signs of scrapie were negative for PrP$^{\rm d}$ in brain but positive in LRS tissues, and one goat showed biochemical and IHC features of PrP$^{\rm d}$ different from all other infected goats. The results of this study have implications for surveillance and control policies for scrapie in goats