595 research outputs found
Magnon-driven quantum-dot heat engine
We investigate a heat- to charge-current converter consisting of a
single-level quantum dot coupled to two ferromagnetic metals and one
ferromagnetic insulator held at different temperatures. We demonstrate that
this nano engine can act as an optimal heat to spin-polarized charge current
converter in an antiparallel geometry, while it acts as a heat to pure spin
current converter in the parallel case. We discuss the maximal output power of
the device and its efficiency.Comment: 6 pages, 4 figures, published version, selected as Editor's choic
Transport in metallic multi-island Coulomb blockade systems: A systematic perturbative expansion in the junction transparency
We study electronic transport through metallic multi-island Coulomb-blockade
systems. Based on a diagrammatic real-time approach, we develop a computer
algorithm that generates and calculates all transport contributions up to
second order in the tunnel-coupling strengths for arbitrary multi-island
systems. This comprises sequential and cotunneling, as well as terms
corresponding to a renormalization of charging energies and tunneling
conductances. Multi-island cotunneling processes with energy transfer between
different island are taken into account. To illustrate our approach we analyze
the current through an island in Coulomb blockade, that is electrostatically
coupled to a second island through which a large current is flowing. In this
regime both cotunneling processes involving one island only as well as
multi-island processes are important. The latter can be understood as
photon-assisted sequential tunneling in the blockaded island, where the photons
are provided by potential fluctuations due to sequential tunneling in the
second island. We compare results of our approach to a P(E)-theory for
photon-assisted tunneling in the weak coupling limit.Comment: 14 pages, 7 figures, published version; minor changes in Sec. IV
Diffraction of complex molecules by structures made of light
We demonstrate that structures made of light can be used to coherently
control the motion of complex molecules. In particular, we show diffraction of
the fullerenes C60 and C70 at a thin grating based on a standing light wave. We
prove experimentally that the principles of this effect, well known from atom
optics, can be successfully extended to massive and large molecules which are
internally in a thermodynamic mixed state and which do not exhibit narrow
optical resonances. Our results will be important for the observation of
quantum interference with even larger and more complex objects.Comment: 4 pages, 3 figure
Multi Mode Interferometer for Guided Matter Waves
We describe the fundamental features of an interferometer for guided matter
waves based on Y-beam splitters and show that, in a quasi two-dimensional
regime, such a device exhibits high contrast fringes even in a multi mode
regime and fed from a thermal source.Comment: Final version (accepted to PRL
SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline
Intrathecal administration enables central nervous system delivery of drugs that do not bypass the blood-brain barrier. Systemic administration of hypertonic saline (HTS) enhances delivery of intrathecal therapeutics into the neuropil, but its effect on solute clearance from the brain remains unknown. Here, we developed a dynamic in vivo single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging platform to study the effects of HTS on whole-body distribution of the radiolabeled tracer (99)mTc-diethylenetriaminepen-taacetic acid (DTPA) administered through intracisternal, intrastriatal, or intravenous route in anesthetized rats. Co-administration of systemic HTS increased intracranial exposure to intracisternal (99)mTc-DTPA by similar to 80% during imaging. In contrast, HTS had minimal effects on brain clearance of intrastriatal (99)mTc-DTPA. In sum, SPECT/CT imaging presents a valuable approach to study glymphatic drug delivery. Using this methodology, we show that systemic HTS increases intracranial availability of cerebrospinal fluid-administered tracer, but has marginal effects on brain clearance, thus substantiating a simple, yet effective strategy for enhancing intrathecal drug delivery to the brain.Peer reviewe
Improved Limit on Direct α Decay of the Hoyle State
The current evaluation of the triple-α reaction rate assumes that the α decay of the 7.65 MeV, 0+ state in 12C, commonly known as the Hoyle state, proceeds sequentially via the ground state of 8Be. This assumption is challenged by the recent identification of two direct α-decay branches with a combined branching ratio of 17(5)%. If correct, this would imply a corresponding reduction in the triple-α reaction rate with important astrophysical consequences. We have used the 11B(3He,d) reaction to populate the Hoyle state and measured the decay to three α particles in complete kinematics. We find no evidence for direct α-decay branches, and hence our data do not support a revision of the triple-α reaction rate. We obtain an upper limit of 5×10-3 on the direct α decay of the Hoyle state at 95% C.L., which is 1 order of magnitude better than a previous upper limit
CRT-700.34 Short-Term Outcomes Among Aortic Valve Stenosis Patients Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention
Background: Among patients undergoing percutaneous coronary intervention (PCI), severe aortic stenosis (AS) is associated with an increased risk of adverse outcomes. Although the use of mechanical circulatory support with Impella has been shown to improve 90-day outcomes in patients undergoing high-risk PCI (HRPCI), there is little information about the safety of this approach in pts with severe AS. We, therefore, sought to evaluate the efficacy and safety outcomes of Impella-supported HRPCI among patients with varying severity of AS.
Methods: We studied patients enrolled in PROTECT III—a multicenter study of patients undergoing Impella-supported HRPCI. Patients were classified according to the severity of AS: none/trivial, mild, moderate, and severe. The primary outcome was the rate of major adverse cardiac and cerebrovascular events (MACCE) at 90 days, defined as the composite of all-cause death, MI, stroke/ TIA, and revascularization. Secondary outcomes included in-hospital PCI-related complications, stroke/TIA, and vascular complications requiring surgery.
Results: Of 596 patients with echocardiographic data, 490 had no/trivial AS, and 34, 27, and 45 had mild, moderate, or severe AS, respectively. Patients with AS were older, less likely to have diabetes, more likely to have left main disease, and had higher left ventricular ejection fractions (Table). Severely calcified lesions and the use of atherectomy were more frequent among patients with moderate or severe AS. There were no differences in rates of PCI-related complications, stroke/TIA, 30-day MACCE, or 90-day MACCE according to AS severity. Rates of transfusion were higher among patients with AS—regardless of severity.
Conclusion: Among patients undergoing Impella-supported HRPCI, PCI-related complications and 90-day outcomes did not differ based on AS status or severity
The resultant on compact Riemann surfaces
We introduce a notion of resultant of two meromorphic functions on a compact
Riemann surface and demonstrate its usefulness in several respects. For
example, we exhibit several integral formulas for the resultant, relate it to
potential theory and give explicit formulas for the algebraic dependence
between two meromorphic functions on a compact Riemann surface. As a particular
application, the exponential transform of a quadrature domain in the complex
plane is expressed in terms of the resultant of two meromorphic functions on
the Schottky double of the domain.Comment: 44 page
Status of evaluated data files for 238U in the resonance region
Experimental data and evaluated data libraries related to neutron induced reaction cross sections for 238U in the resonance region are reviewed. Based on this review a set of test files is produced to study systematic effects such as the impact of the upper boundary of the resolved resonance region (RRR) and the representation of the infinite diluted capture and in-elastic cross section in the unresolved resonance region (URR). A set of Benchmark experiments was selected and used to verify the test files. Based on these studies recommendations to perform a new evaluation have been defined.
This report has been prepared in support to the CIELO (Collaborative International Evaluated Library Organisation) project. The objective of this project is the creation of a world-wide recognised nuclear data file with a focus on six nuclides, i.e. 1H, 16O, 56Fe, 235U, 238U and 239Pu. Within the CIELO project, the Joint Research Centre (JRC) at Geel (B) is in charge of the production of an evaluated cross section data file for neutron induced reaction of 238U in the resonance region.JRC.D.4-Standards for Nuclear Safety, Security and Safeguard
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