Economic Development of Siberia during Reforms of Peter I: Craft and Emergence of Industry

The features of the industrial development of the Siberian region at the end of the 17th — the first quarter of the 18th centuries are studied. The analysis of legislative and clerical, statistical sources, generalization and systematization of the results of research in the field of development of the Siberian handicraft and manufacturing production of the late 17th — first quarter of the 18th centuries made it possible to identify the degree of influence of Peter I’s reforms on this process. It is concluded that in the period under review, the main form of industrial production in Siberia was small-scale handicraft production, in many sectors of which progress was observed, due both to the improvement of the technological process and to the regulatory orders of Peter I of a national and regional nature. It is noted that in the complex of transformative undertakings, Peter I paid special attention to Siberia, although in some cases the regulatory provisions of the royal decrees regarding certain types of handicraft production did not give much effect in the region, as was the case, for example, with the decrees of 1715 on the prohibition of tanning leather without the use of blubber and the manufacture of narrow linen and hemp cloths. The most significant government decrees with a regional focus on crafts related to stone building and river shipbuilding. The authors of the article show that an important result of the reform activities of Peter I was the development of large-scale manufactory and factory production in Siberia

Development of Education in Siberia in First Quarter of 18th Century

The article is devoted to the study of the schooling formation on the territory of the Siberian province in the first quarter of the 18th century. The process of origin and development of spiritual and secular education in Siberia is characterized. The study was carried out on the basis of an analysis of the decrees of Peter I published in the Complete Collection of Laws of the Russian Empire, which regulate the organization of educational institutions in Siberia. A number of clerical sources of the Russian State Archive of Ancient Acts, in particular, the cases of the Siberian Order, are analyzed. Also, to study the topic, materials from the newspaper “Tobolsk Gubernskie Vedomosti” were involved. The authors of the article show that Peter’s modernization processes in the field of education were reflected in the life of the Siberian province in the first quarter of the 18th century. It is concluded that the main changes that affected the field of education are associated with the implementation of the reforms of Peter I. The role of the first theological schools in the education system of the Siberian province, the significance of the decrees of Peter I and the activities of the Orthodox Church in their formation are considered. At the same time, it is proved that the political events and cultural innovations of the Petrine era contributed to the formation of secular education and the spread of enlightenment among Siberians

Formation of a Pension Allowance system for Civil Servants of the Tobolsk Province of the 19th - early 20th Centuries

The article is devoted to the study of historical experience in the formation of pensions for employees of the Tobolsk province in the XIX - early XX centuries. The authors of the article associate their interest in the indicated problems with its poor knowledge, as well as the reform of pension provision in modern Russia. The source of the study was the legislative, clerical and statistical documents of the funds of the School Directorate, City Council, Tobolsk Provincial Board, Tobolsk State Chamber, Tobolsk Gymnasium, Tobolsk State Bank, Tobolsk Post and Telegraph Office, Tobolsk Notary Archive and others. The most significant of these are the lists of pensioners living in the Tobolsk province, the Tobolsk Treasury Chamber statements on pensioners, documents that fix the number and size of pensions issued and not issued, and cases regarding the assignment of pensions. The authors of the article note the absence in the period under review of a single pension provision practice for all social categories of the population. The author analyzes pension payments accrued to officials from the treasury, and funded payments from public emmeritial cash desks. It is concluded that the formation of the pension provision of civil servants can be attributed to the end of the first quarter of the XIX century. The circle of persons entitled to receive a pension is designated, the sources of pension financing are identified. It was concluded that for the provision of pensions to officials of the period under review, the dependence of the pension salary on the size of the annual salary, the rank and length of service of the civil service was characteristic

Image of Peter I in Newspaper Materials of “Tobolsk Gubernskiye Vedomosti” (1857—1909)

The issue of reconstructing the image of Peter I on the pages of “Tobolsk Gubernskiye Vedomosti” is considered. The newspaper materials selected for the study reflect public opinion about the personality and transformations of Peter I and at the same time represent the source of Peter I image formation in the mass consciousness of the “Tobolsk Gubernskiye Vedomosti” readers. The purpose of the research is to study examples of the construction of the image of Peter I on the pages of the newspaper “Tobolsk Gubernskie Vedomosti”. Literary and comparative-historical approaches to the study of this problem are used. The analysis of the texts of newspaper materials published from 1857 to 1909 is carried out, and cases of mentioning the name of Peter the Great in the context of the events of all-Russian and local history are described.  The authors concluded that the newspaper participated in the preservation and consolidation of the name of the tsar and the events of his reign in the historical memory of Siberians. Examples of the formation of the image of an ideal ruler through various news reports of the newspaper “Tobolsk Gubernskiye Vedomosti” is considered in the study. It is proved that the newspaper supported the myth of Peter I as an idol, an enlightened autocrat, under whose reign Russia achieved prosperity and power. The publications of various genres reflect a positive attitude towards the tsar, as this corresponded to the policy of the official printed organ — the strengthening of monarchical ideals in the mass conscious-ness

Educational game systems in artificial intelligence course

Article actuality based on fact that existing knowledge system aimed at future professional life of students: a skillful use game activity in educational process will teach students to look for alternative ways solving of real problems. The purpose of article lies in theoretical substantiation, development and testing of criteria, which must be met by special-purpose software oriented on gamification of educational process. A leading research method of the described problem is a method of simulation that allows to consider gamification as concentration and organized process for increasing the factor of student engagement in cognitive activity. This article aimed to demonstrate models of ideal educational game programs with optimum number of gamification elements, also article focused on development of such software, which will be not entertaining, but educational in nature. The article may be useful for researchers dealing with gamification issues and software developers, which works relate with educational programs. © 2016 Chubarkova et al

Seasons dynamics of biochemical parameters of blood of cows during the dry period

The study of the metabolism in the body of cows, depending on the physiological state, factors of feeding and the conditions of content in different seasons of the year, is a necessary condition for the direct effect on their reproductive capacity and productivity. In particular, the scientific and practical interest is the disclosure of physiological and biochemical mechanisms, which are associated with the characteristics of metabolism in the body of cows during pregnancy. The purpose of the research was to study the features of protein metabolism in highly productive deep-calving cows in different seasons of the year. The object for the study is served cows with milk production of 5–6 thousand kg for lactation at 8–9 months of pregnancy and blood samples taken from them. Biochemical study of cows blood plasma was carried out according to generally accepted methods. The recorded seasonal changes in protein exchange of deep-calving cows (Table) were cyclic. In contrast to the total protein content, seasonal differences in its fractional composition were also detected. The dynamics of the change in protein ratio is similar to that of albumin. During the summer, the content of a-globulins increased by 20.1 %, b-globulins by 17.3 %, g-globulins per 20.5 % compared with the spring period. In dry-bodied cows, the activity of ALT and AST in winter increases, reaching its maximum value but in the summer activity of ALT significantly decreased, and its activity was even less than the physiological limits. ACT activity was the lowest in the autumn. Determined that seasonal changes in the protein metabolism of dry cows were cyclic character. A decrease in the content of globulins (due to a-, b- and g-globulins) was observed during the winter period compared to the summer period. This characterizes the high activity of protein metabolism in the summer with the decline in winter. In dry cows, the albumin content and protein ratio reached a maximum in winter with a significant decrease in spring and summer, and in the autumn they again started to rise. The degree and direction of changes in ALT and AST activity were similar to seasonal changes in albumin content. This indicates a low intensity of protein-synthesizing processes in the liver in summer

Investigation of Prince M. P. Gagarin’s Case in Context of Development of State Control System in First Quarter of 18th Century

The article investigates the activities of Prince Matvey Petrovich Gagarin as the first governor of Siberia. The materials of his investigation case are examined in the context of the development of the state control system over the actions of government authorities during the reign of Peter I. The process of creating legislation and special controlling and judicial bodies aimed at regulating the limits of powers of civil servants, identifying and preventing their violations, is characterized. The study is based on the analysis of legislative sources regulating the organization of new administrative-territorial divisions. A number of documentary sources from the Russian State Archive of Ancient Acts are analyzed, including cases from the Siberian Office, orders from Governor M. P. Gagarin, reports from commanders of Siberian cities, petitions from various individuals, and other materials. It is shown that the organization of investigative measures and the criminal case process against Prince M. P. Gagarin were under the personal control of Peter I. The conclusion is drawn that Prince M. P. Gagarin was an active participant in many reforms initiated by the reformist tsar. At the same time, it is demonstrated that Prince Gagarin’s biography is a vivid example of the collision between the widespread practice of enrichment by aristocratic clans and Peter I’s principles and views on the essence and place of official service in his “regular” police state

Problems of Sects Classification and Typology (on Materials of Tobolsk Governorate of the Second Half of XIX - Early XX Century)

The article is devoted to the typology of religious sectarianism, which spread in the territory of the Tobolsk governorate in the second half of XIX - early XX century. Material is the complex of management and statistical sources, that are stored by the State archive in Tobolsk. It is demonstrated that the documents show a steady growth the followers of the sects of Skoptsy , Khlysty , Doukhobory , Shtundists, nemolyaki , subbotniki , Baptists, Adventists, Molokans, Mennonites in the governorate during the considered chronological period. The authors point to the lack of a common terminology in the sources, to many self-designations in the followers of sects, note the difficulty of accounting the sectarians for the local Church and the administrative-police apparatus of control. The need to study these aspects at the present stage is emphasized. The definitions of sectarianism are given. Its distinctive features and characteristics are presented. The comparative-critical analysis (in terms of chosen territorial and chronological boundaries) of classifications of sectarianism available in science, contained in the works of Russian pre-revolutionary, Soviet and modern researchers, is made. For further study of the history of sectarianism, the authors took as a basis the idea of dividing the sects in the rationalistic and the mystical. The appeal to the historical periodization of the development of sectarianism allowed to justify the religious nature of the sects operating in the territory of the Tobolsk governorate

Immunogenetic profile of MIC (A, B) HLA loci linked to MHC antigenic complex in Russians of the Chelyabinsk Region

The MIC genes are located on chromosome 6 in the class I major histocompatibility complex (MHC) region and encode a membrane-bound stress-inducible protein that acts as a ligand to stimulate the NKG2D activating receptor expressed on the surface of the most natural killer cells (NK). Currently, 7 MIC loci are known, of which only MICA and MICB encode proteins and show a significant allelic polymorphism. The MIC gene polymorphism and their location in the HLA region suggests presence of some ethnic and populational differences for the gene frequencies, linkage disequilibrium of distinct loci, and distribution of HLA-MIC haplotypes, thus making it possible to get information on genetic relationship of human populations. The aim of our study was to assess immunogenetic profile of Russian population in Chelyabinsk Region based on the non-classical HLA loci, i.e., MICA and MICB, in the context of worldwide population data. Methods of the study included immunogenetic typing of 100 donors identifying themselves as Russians, taken from the Registry of Stem Cell Donors at the Chelyabinsk Regional Blood Transfusion Station. The 2 loci (MICA and MICB) were typed at basic resolution, using PCR technique with sequence-specific primers (SSP-PCR). Gene frequencies (GF) were calculated using programs for immunogenetic research (Arlequin 3.5).Among Russian population from Chelyabinsk Region, the following characteristics of the MICA gene distributions were found: MICA *008, *002, *010, *009, frequency of > 7%; average frequencies, for MICA *004, *007, *018, *017; whereas MICA *027, *011, *006, *009:02, *049, *012, *016 was registered at a frequency of < 3.5%. MICB gene profile was as follows: MICB *005:02, *004, *002, *008 at a frequency of > 6%; at a frequency of 4% MICB *003, *005:03; MICB *005:01, * 005:04, * 009N, MICB *013, *014 at a frequency of0.5%. As based on calculated genetic distances (according to Ney) for the MICA locus, the dendrogram and scatter plot were designed by means of multidimensional scaling (MDS) method, presenting location of 30 world populations, including data on Russians in Chelyabinsk Region. The smallest genetic distances between the population of Russians from Chelyabinsk Region and other world populations were found between the population of Slovenia, as well as the USA population of European origin. As based on scatterplot obtained by the MDS approach for MICA gene frequencies, using the data of cluster analysis, we have found that the population of Russians from Chelyabinsk Region belongs to a cluster of typical European populations.The obtained patterns could be used for practical purposes to create a registry of stem cell donors in Russia. In addition, the data may be used as a control group for further research in the area of HLA-disease association, and could be also demanded by the specialists in population ethnogenesis

CIRCULATING BIOMARKERS OF SYSTEMIC INFLAMMATORY RESPONSE IN THE ASSESSMENT OF POSTPERICARDIOTOMY SYNDROME IN PATIENTS AFTER CARDIAC SURGERY

Postpericardiotomy syndrome (PCTS) is one of the most frequent cardiac surgery complications seen in 9-65% of patients. Despite its widespread occurrence, the mechanisms of the development of PCTS are still understudied. drug. The use of colchicine in cardiac surgery patients is of particular interest. Due to the ability of this drug the colchicine mechanisms of action are able to inhibit the mobilization of the NLRP3 inflammasome assembly, to suppress the activation of caspase-1. As a result, it can prevent the release of proinflammatory cytokines, namely IL-1β and IL-18. There are conflicting data on the effect of colchicine on the PCTS progression within the systemic inflammatory response after cardiac surgery. In this regard, it was important to study the dynamics of serum levels of IL-6, IL-10, IL-1β, and TNFα in patients before coronary artery bypass grafting (T1), 6 hours (T2), and 10 days (T3) after surgery, and to evaluate the effect of colchicine on the development of PCTS. The results of our research showed a significant increase of IL-10 in both groups 6 hours after surgery. However, on the 10th day, the increase in the level of IL-10, compared with the initial values, was higher in the 1st group – 2 times, compared with the 2nd group. In both groups, showed significant increase in serum concentration of IL-6 after 6 h surgery, with a subsequent decrease in the expression at the stage of T3, while the IL-6 levels in the 2nd group was statistically notably higher than T1. The incidence of pleurisy was lower in the group of patients taking colchicine. Only in the 1st group IL-6 levels were directly associated with IL-10. In patients with pleurisy, the level of released IL-10 and TNFα was significantly higher in the 2nd group. There were no significant intergroup differences in serum levels of IL-1β and TNFα, as well as significant changes in IL-1β between the stages of observation. Analysis of TNFα expression revealed significant differences in TNFα content in the 1st group between the T1-T3 and T2-T3 stages. In both groups, multiple positive associations were found between the studied indicators. Thus, data were obtained indicating the antiinflammatory effect of colchicine in cardiac surgery patients. This was clinically expressed in a tendency to a lower incidence of pleurisy, and was accompanied by increased expression of IL-10, which has an antiinflammatory and immunomodulatory effect against the background of the drug in the postoperative period