Eribulin-trastuzumab combination in HER2-positive metastatic breast cancer: updated results from a Russian observational study

Introduction. The standard of 1st line treatment of HER2+ metastatic breast cancer (mBC) is double blockade with trastuzumab and pertuzumab + taxane, 2nd line – Trastuzumab-emtazine. There are no standards for further treatment, as well as the optimal drug sequence. Expansion of the arsenal of therapeutic possibilities and the use of new combinations will certainly improve the results of treatment of this category of patients and increase their life expectancy.Aim. We sought to describe treatment patterns of  eribulin  and clinical outcomes of  metastatic HER2-positive breast cancer treated with eribulin  plus trastuzumab combination in  academic institutions and community oncology practices across the Russian Federation.Materials and methods. Patients treated with eribulin anytime between Jan, 2014 and Sep, 2019 with a diagnosis of MBC were identified by 23 providers from Russia. Providers retrospectively reviewed the health records and abstracted selected data points into an electronic case report form for each eligible patient.Results. 100 HER2-positive pts received eribulin in combination with trastuzumab. Median age was 55 (31–80) yrs and ECOG status 0–3. 67% pts had visceral metastases. Eribulin was administered as 1st and 2nd line to 23 (23%) pts, 3rd line to 31 (31%) pts, 4th line and later to 46 (46%). Median number of cycles was 5 (2–27). ORR was 12%, SD – 72%, SD > 6 months – 23%, PD – 16%. Clinical efficacy rate achieved in 35%. Median PFS was 5.07 months (95% CI 4.021–6.119). According to the ER-status the response to eribulin and trastuzumab was different. ORR was 18.8%, SD 72.9% in pts with ER-positive MBC (n = 48) and 5.8% and 71.2% respectively in ER-negative MBC (n = 52). Median PFS was 6.97 months (95% CI 3.924–10.016) in pts with ER-positive MBC and 4.67 months (95% CI 3.841–5.499) in ER-negative MBC (р = 0.3). The combination was well tolerated: dose reductions were required in 12% pts, withdrawal due to toxicity in 4% pts. The most common type of toxicity was hematological with neutropenia Gr III-IV in 14 (14%) pts. Peripheral neuropathy Gr III was observed in 5 (5%) pts. No cardiotoxicity was detected.Conclusions. This is the real-life data of clinical outcomes for patients receiving eribulin plus trastuzumab for HER2-positive MBC throughout the Russian Federation. Our experience with eribulin plus trastuzumab demonstrates that this combination may be a potential effective treatment option for HER-2 positive MBC patients

Integration Aspects of Using the ABC-method in Trade Organization

The recent crisis in Russia’s economy has resulted in noticeably decreased demand and increased competition. Under these conditions Russian companies were forced to pay closer attention to generation of management accounting information, the quality of which largely determines the effectiveness of their decisions. In its turn, improvement of the quality of information calls for modifying the standard methods or using the new methods of processing information such as “Activity-based costing” (ABC method). It should be noted that most articles describe the implementation of the ABC method by industrial enterprises, and only some papers focus on application of this method in trade. However, Western scientists consider the ABC method to be equally applicable to production and trade. Hence it becomes relevant to seek ways of implementing the ABC method in trade, taking into account its peculiarities, and what is more - to find the possibilities of integrating this method with the trade accounting data, which is the purpose of writing this article

Inaugural Speech as A Tool of Forming Speech Portrait of the President

The paper deals with the inaugural speeches of Vladimir Putin (2018) and Donald Trump (2017) and is aimed at analyzing the role of verbal means in forming the speech portraits of political leaders. The article is of urgent interest as it demonstrates the speech portraits of country leaders in relation to national identity, mentality and socio-political course of the country. By means of comparative content analysis we looked for grammatical, lexical and stylistic elements peculiar to a specific linguistic persona while comparing the speeches of the presidents as well as we attempted to determine the specific national backgrounds of political discourse. Thus, each president's inauguration context model is mostly characterized by a different set of linguistic means. The paper findings may be useful for researchers who deal with interdisciplinary studies, political and cognitive linguistics, political discourse and communication analysis