Biomarkers in post-reperfusion syndrome after acute lower limb ischaemia

Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns to the tissue after a period of ischaemia. Matrix metalloproteinases (MMPs), neutrophil gelatinase-associated lipocalin (NGAL) and cytokines are biomarkers involved in several vascular complications. The aim of this study was to evaluate the role of MMPs, NGAL and inflammatory cytokines in I/R syndrome. We conducted an open label, multicentric, parallel group study, between January 2010 and December 2013. Patients with acute limb ischaemia were enrolled in this study and were divided into two groups: (i) those subjected to fasciotomy and (ii) those not subjected to fasciotomy, according to the onset of compartment syndrome. Plasma and tissue values of MMPs and NGAL as well as plasma cytokines were evaluated. MMPs, NGAL and cytokine levels were higher in patients with compartment syndrome. Biomarkers evaluated in this study may be used in the future as predictors of I/R injury severity and its possible evolution towards post-reperfusion syndrome

preliminary results of principe predictors of resistance to immunotherapy with nivolumab niv study in advanced pretreated non small cell lung cancer apnsclc investigating the role of an immune genomic signature igs including jak2 jak3 pias4 ptpn2 stat3 ifnar2 alterations

n/

New perspectives in silicon micro and nanophotonics

In the last two decades, there has been growing interest in silicon-based photonic devices for many optical applications: telecommunications, interconnects and biosensors. In this work, an advance overview of our results in this field is presented. Proposed devices allow overcoming silicon intrinsic drawbacks limiting its application as a photonic substrate. Taking advantages of both non-linear and linear effects, size reduction at nanometric scale and new two-dimensional emerging materials, we have obtained a progressive increase in device performance along the last years. In this work we show that a suitable design of a thin photonic crystal slab realized in silicon nitride can exhibit a very strong field enhancement. This result is very promising for all photonic silicon devices based on nonlinear phenomena. Moreover we report on the fabrication and characterization of silicon photodetectors working at near-infrared wavelengths based on the internal photoemission absorption in a Schottky junction. We show as an increase in device performance can be obtained by coupling light into both micro-resonant cavity and waveguiding structures. In addition, replacing metal with graphene in a Schottky junction, a further improve in PD performance can be achieved. Finally, silicon-based microarray for biomedical applications, are reported. Microarray of porous silicon Bragg reflectors on a crystalline silicon substrate have been realized using a technological process based on standard photolithography and electrochemical anodization of the silicon. Our insights show that silicon is a promising platform for the integration of various optical functionalities on the same chip opening new frontiers in the field of low-cost silicon micro and nanophotonics

Investigating the seismic response of URM walls with irregular opening layout through different modeling approaches

TThe façade and internal walls of unreinforced masonry (URM) buildings often present an irregular opening layout, due to architectural reasons or modifications to the structure, which make the expected seismic damage pattern less predictable a priori. Therefore, the discretization of the walls in structural components is not standardized, conversely to cases with a regular opening layout for which the available modeling methods are corroborated by seismic damage surveys reporting recurrent failure patterns. The structural component discretization is a relevant step for the code-conforming seismic assessment, typically based on comparing the internal forces and drifts of each component to strength criteria and drift thresholds. Therefore, the lack of well-established approaches can significantly influence the assessment. The issue is even more evident when the structural components must be identified a priori in the modeling stage, namely for equivalent frame models. The applicability of available methods for discretization of URM walls with irregular opening layout has been already investigated in literature, but a conclusive judgment requires further studies. In this context, this paper presents an overview of the preliminary results addressing the numerical modeling of this type of walls within the framework of the DPC-ReLUIS 2022-2024 project (Subtask 10.3), funded by the Italian Department of Civil Protection. The Subtask aims to propose consensus-based recommendations for researchers and practitioners which can contribute to harmonize the use of different modeling approaches. Seven research groups are involved in the research, adopting different modeling approaches and computer codes, but similar assumptions and the same analysis method (pushover) are used. The benchmark URM structure illustrated in the paper is a two-story wall from which four configurations with increasing irregularity of opening layout were derived. The results of four modeling approached are presented. Three of them reproduce the mechanical response of masonry at the material scale by means of FE models implemented in OpenSees, DIANA and Abaqus software, while the remaining approach describes the mechanical response of masonry at the macro-element scale in 3DMacro software. Results were compared in terms of capacity curves, predicted failure mechanisms and evolution of internal forces in piers. The adoption of consistent assumptions among the different approaches led to an overall agreement of predictions at both wall and pier scales, particularly in terms of damage pattern with higher concentration of damage at the ground story. Despite that, differences on the pushover curves have been highlighted. They are mainly due to some deviations of the internal forces in squat piers deriving from a complex load flow in these elements.DPC - Dipartimento della Protezione Civile, Presidenza del Consiglio dei Ministri(LA/P/0112/2020

Larinum: the development of the forum area

Presentazione dei risultati delle campagne di scavo condotte a Larino dalla misssione archeologica dell'Università 'Sapienza' di Roma. Il lavoro si sofferma sulla ricostruzione culturale dell'insediamento, analizzato attraverso la comprensione dell'impianto urbano e delle sue trasformazioni nel tempo. La ricerca sul terreno concerne in particolare l'area del foro, di cui viene ricostruita per la prima volta la planimetria complessiva e il processo di monumentalizzazione. Di particolare interesse appare il riconoscimento dei forti cambiamenti strutturali, di orientamento e di impianto viario, che segnano in maniera determinante lo sviluppo urbanistico del centro, soprattutto nella fase tardo-repubblicana. Si traccia quindi un profilo della comunità di Larino dagli inizi del processo di costituzione dell'abitato (dalle prime testimonianze dell'età del ferro) sino alle fasi di destrutturazione intervenute verso il VI-VII sec. d.C., quando gran parte dell'area urbanizzata subisce un processo di contrazione e di progressivo abbandono

Larinum: lo sviluppo dell'area forense e della città

Esame dello sviluppo urbanistico e architettonico di Larino e del suo spazio forense in particolare

Corporate Governance and Performance: an empirical analysis of a Sector Listed in Italian stock Exchange

Studies on corporate governance have undergone rapid development since the last decades of the twentieth century, when both entrepreneurs and company men began to pay considerable attention to the subject. However, the actual debate began in the early nineties when, following the numerous financial scandals, companies were forced to better define the control mechanisms within them. Most reported cases of corporate failure are attributed to corporate governance practices (Appiah, 2013). We have begun to assist on a global scale, the important role attributed to the mechanisms of Corporate Governance as their correct application is closely related to company performance (Donaldson, 2003). On the basis of these considerations, the idea of the present work arises which, through a quantitative approach, investigates how the different composition and structure of the board influences the performance of the companies. The companies being analyzed are the mechanical companies listed on the Milan stock exchange for the three-year period 2015-2016-2017. We chose to analyze the mechanical companies thanks to the role they play in our country, in terms of employment, in terms of international trade and above all with reference to the strategic role they fulfill, strongly contributing to the development of the country and to the preservation of the levels of competition from the entire industrial sector. In the elaboration of the dataset, with regard to the governance data, the analysis of the corporate governance relations published annually by each company was used. To relate the governance variables to company performance we used a single financial statement indicator: the ROE (accounting measure), the most popular financial measure was used. I risultati del presente lavoro dimostrano che la dimensione del Consiglio di amministrazione ha un‟influenza positiva sulla redditività delle società ed anche la maggiore presenza di donne all‟interno del CdA. This study intends to examine how board diversity in companies operating in engineering, impact on performance. After a brief introduction to Corporate governance and firm performance, the work shows an adequate review of the most significant national and international literature on the subject. The research method used to analyze the topic is empirical using governance variable from corporate governance reports. This work tries to study deeply the impact of board diversity on firm performance by some listed company

Assessment of the seismic vulnerability of an unreinforced masonry structure based on discrete-macro dynamic analyses

UnReinforced Masonry (URM) structures experience severe damage due to in-plane and out-of-plane mechanisms when subjected to seismic actions. The assessment of the seismic vulnerability of URM generally requires complex analytical procedures consisting of the application of sophisticated numerical models. However, these models may request a high computational effort or may present an over-simplified scheme, mainly when the out-of-plane mechanisms are neglected. In this sense, a 3-dimensional macro-element model is here used for a preliminary assessment of the seismic vulnerability of a URM prototype characterized by an out-of-plane collapse mechanism. In this paper, the seismic vulnerability of this type of constructions is investigated by means of fragility functions in accordance with specific damage states and a given seismic input. The structural safety assessment was conducted by means of time history analyses with a limited computational effort. In addition, the evaluation of the limit states is here performed by means of an alternative approach named as Capacity Dominium based on the application of nonlinear static analyses.Peruvian Institution Innovate Perú/FINCyT (Fondo para la Innovación, Ciencia y Tecnología) through the PhD grant BECA-1-P-078-1