Systematic effects induced on IBIS detectors by background and inhomogeneity of the spatial response

The spatial distribution of the background events may affect the source detection capability of IBIS at high energies (> 200 keV) for both ISGRI and PICsIT layers. The observed background is found to be variable and spatially structured, and in some cases its properties strongly deviate from the expected statistical behaviour. Background correction methods are then necessary to improve the quality of the shadowgrams obtained from sources. In order to perform an efficient flat-fielding the response of the detector to both source gamma-rays and background events is investigated using data from Monte Carlo simulations and in-flight calibration observations.Comment: 5 pages, 1 latex file, 6 figures, accepted for publication on Astronomy and Astrophysics, INTEGRAL special issu

Scientific Performance of the ISDC Quick Look Analysis

The INTEGRAL Science Data Centre (ISDC) routinely monitors the Near Real Time data (NRT) from the INTEGRAL satellite. A first scientific analysis is made in order to check for the detection of new, transient or highly variable sources in the data. Of primary importance for this work is the Interactive Quick Look Analysis (IQLA), which produces JEM-X and ISGRI images and monitors them for interesting astrophysical eventsComment: 4 pages, 3 figures. Proceedings of 5th INTEGRAL Workshop: The INTEGRAL Universe, Munich, 16-20 February 2004. Accepted for publication in European Space Agency Special Publication 552. See paper for institute affiliation

The INTEGRAL/IBIS Scientific Data Analysis

The gamma-ray astronomical observatory INTEGRAL, succesfully launched on 17th October 2002, carries two large gamma-ray telescopes. One of them is the coded-mask imaging gamma-ray telescope onboard the INTEGRAL satellite (IBIS) which provides high-resolution (~ 12') sky images of 29deg x 29deg in the energy range from 15 keV to 10 MeV with typical on-axis sensitivity of ~ 1 mCrab at 100 keV (3 sigma, 10E6 s exposure). We report here the general description of the IBIS coded-mask imaging system and of the standard IBIS science data analysis procedures. These procedures reconstruct, clean and combine IBIS sky images providing at the same time detection, identification and preliminary analysis of point-like sources present in the field. Spectral extraction has also been implemented and is based on simultaneous fitting of source and background shadowgram models to detector images. The procedures are illustrated using some of the IBIS data collected during the inflight calibrations and present performance is discussed. The analysis programs described here have been integrated as instrument specific software in the Integral Science Data Center (ISDC) analysis software packages currently used for the Quick Look, Standard and Off-line Scientific Analysis.Comment: 7 pages, 13 figures (6 color), accepted for publication in A&A Lett (INTEGRAL special issue). Full resulution color figures can be found in the printed version of the paper (see http://www.edpsciences.org/articles/aa/abs/2003/43/contents/contents.html

Traitements de la sclérose en plaques : mise à jour [Treatments for multiple sclerosis: update]

The management of multiple sclerosis (MS) has undergone a veritable revolution in recent years, with the arrival of highly effective treatments. In some cases, therapeutic discussions even precede the first clinical signs of the disease. The aim of this review is to present the therapeutic arsenal of progression-preventing treatments available in 2024 for MS, with anti-CD20 antibodies taking pride of place, also available for certain progressive forms of MS. The use of these immunosuppressants requires in-depth knowledge of their mechanisms of action, in order to understand their risks, such as the occurrence of opportunistic infections