CHOICE OF MATERIAL AND MANUFACTURING TECHNOLOGY OF CASTING

As a result of the carried out work abundant type of steel was chosen for casting production of asterisk of the excavator «Kamatsu». This type of steel is widely used as the wearproof steel working in the conditions of abrasive and shock – abrasive wear. Mathematical modeling of process of filling and hardening of casting was done and it confirmed a choice of the technology to produce casting without faulty parts

The origin of quasi-periodicities during circular ribbon flares

Solar flares with a fan-spine magnetic topology can form circular ribbons. The previous study based on H\alpha line observations of the solar flares during March 05, 2014 by Xu et al. (2017) revealed uniform and continuous rotation of the magnetic fan-spine. Preliminary analysis of the flare time profiles revealed quasi-periodic pulsations (QPPs) with similar properties in hard X-rays, H\alpha, and microwaves. In this work, we address which process the observed periodicities are related to: periodic acceleration of electrons or plasma heating? QPPs are analysed in the H\alpha emission from the centre of the fan (inner ribbon R1), a circular ribbon (R2), a remote source (R3), and an elongated ribbon (R4) located between R2 and R3. The methods of correlation, Fourier, wavelet, and empirical mode decomposition are used. QPPs in H\alpha emission are compared with those in microwave and X-ray emission. We found multi-wavelength QPPs with periods around 150 s, 125 s, and 190 s. The 150-s period is seen to co-exist in H\alpha, hard X-rays, and microwave emissions, that allowed us to connect it with flare kernels R1 and R2. These kernels spatially coincide with the site of the primary flare energy release. The 125-s period is found in the H\alpha emission of the elongated ribbon R4 and the microwave emission at 5.7 GHz during the decay phase. The 190-s period is present in the emission during all flare phases in the H\alpha emission of both the remote source R3 and the elongated ribbon R4, in soft X-rays, and microwaves at 4--8 GHz. We connected the dominant 150-s QPPs with the slipping reconnection mechanism occurring in the fan. We suggested that the period of 125 s in the elongated ribbon can be caused by a kink oscillation of the outer spine connecting the primary reconnection site with the remote footpoint. The period of 190 s is associated with the 3-min sunspot oscillations.Comment: Accepted for publication in A&

Патоморфологические особенности строения женских половых органов плодов от матерей с осложнённой беременностью

З метою виявлення впливу прееклампсії тяжкого ступеня матері на патоморфологічні особливості будови яєчників плодів виконали дослідження, під час якого встановили особливості будови яєчників плодів від матерів із прееклампсією важкого ступеня в порівнянні з такою у плодів від здорових матерів. Гістологічними методами виявили розростання сполучної тканини, масову загибель яйцеклітин, переважання у фолікулярному апараті примордіальних фолікулів, що гинуть. Гістохімічне дослідження засвідчило зниження інтенсивності реакції на ДНП в ядрах і на РНП в цитоплазмі клітин. Морфометричним методом встановили вірогідне зниження відносного об’єму фолікулярної тканини, а також вірогідне збільшення відносного об’єму інтерстиціальної тканини. Наведений тип будови яєчників плодів від матерів із тяжким ступенем ПЕ відповідає гіпопластичному і свідчить про порушення закладання та формування гонад у внутрішньоутробному періоді. Визначені особливості будови яєчників можуть сприяти порушенню гермінативної функції в подальшому онтогенезі.In the course of the study the structural features of fetal ovarian of mothers with severe preeclampsia in comparison with fetuses from healthy mothers were revealed. Methods and results. Proliferation of connective tissue; mass mortality of the ovocytes; the prevalence of perishing primordial follicles in the follicular unit were demonstrated histologically. Histochemical methods established reduction in the intensity of the reaction to DNP in the nucleus and in the RNP in the cells cytoplasm. Morphometric method showed significant reduction in the relative volume of the follicular tissue, as well as a significant increase in the relative volume of the interstitial tissue. The described type of fetal ovarian structure of mothers with severe PE corresponds to hypoplastic type and constitutes a violation of the gonads formation in utero.С целью установления влияния преэклампсии тяжёлой степени матери на патоморфологические особенности строения яичников плодов провели исследование, в ходе которого выявили особенности строения яичников плодов от матерей с преэклампсией тяжёлой степени течения в сравнении с таковым у плодов от здоровых матерей. Гистологическими методами показали разрастание соединительной ткани, массовую гибель яйцеклеток, преобладание в фолликулярном аппарате погибающих примордиальных фолликулов. Гистохимическими методами установили снижение интенсивности реакции на ДНП в ядрах и на РНП в цитоплазме клеток. Морфометрическим методом выявили достоверное снижение относительного объёма фолликулярной ткани, а также достоверное увеличение относительного объёма интерстициальной ткани. Описанный тип строения яичников плодов от матерей с ПЭ тяжёлой степени соответствует гипопластическому и свидетельствует о нарушении закладки и формирования гонад внутриутробно. Выявленные особенности строения яичников плодов могут способствовать нарушению герминативной функции в дальнейшем онтогенезе

Effect of Bacillus intermedius ribonucleases with different catalytic activities on the growth of Escherichia coli and Bacillus subtilis

The effect of the Bacillus intermedius ribonuclease and its mutant forms derived by site-specific mutagenesis on the growth of gram-positive and gram-negative bacteria was studied. Both catalytically active and catalytically inactive (mutant) ribonucleases stimulated bacterial growth, the extent of stimulation correlating with the catalytic activity of the enzymes. It was suggested that the biological activity of exogenous ribonucleases is mainly due to their catalytic activity. © 1998 MAHK Hayka/Interperiodica Publishing

Quality management system at the treatment and prevention faculty: experience and prospects ofdevelopment

The article describes the experience of joint interaction of faculty and students within the framework of the quality management system at the medical and preventive faculty, as well as the projects planned in the future.в статье описывается опыт совместного взаимодействия профессорско-преподавательского состава и студентов в рамках системы менеджмента качества на лечебно-профилактическом факультете, а также представлены запланированные в перспективе проект

Effect of bacillus intermedius ribonucleases with different catalytic activities on the growth of escherichia coli and bacillus subtilis

The effect of the Bacillus intermedius ribonuclease and its mutant forms derived by site-specific mutagenesis on the growth of gram-positive and gram-negative bacteria was studied. Both catalytically active and catalytically inactive (mutant) ribonucleases stimulated bacterial growth, the extent of stimulation correlating with the catalytic activity of the enzymes. It was suggested that the biological activity of exogenous ribonucleases is mainly due to their catalytic activity

Integration of quality management system for teachers and students preventive-treatment faculty as a guarantee of quality assurance

The vector for integration of the system of management of quality teachers therapeutic and preventive faculty with the work of the student council on the quality of education through the implementation of project activities aimed at training highly qualified specialists of relevant state educational pattern; Issue konkurentosposobnyhna labor market medical meeting modern requirements of employers.Вектор на интеграцию работы системы менеджмента качества преподавателей лечебно-профилактического факультета и студенческого совета по качеству образования через реализацию проектных работ направлен на подготовку высококвалифицированных специалистов, соответствующих государственному образовательному образцу; выпуск конкурентоспособных на рынке труда врачей, отвечающих современным требованиям работодателей

Morphological peculiarities of the ovaries of the fetuses from mothers with complicated pregnancy

Комплексне вивчення яєчників плодів від матерів, вагітність у яких ускладнена еклампсією, виявило такі особливості: достовірне зниження маси органу і показників основних його розмірів у порівнянні з такими в групі контрольних спостережень. Збільшення відносного об’єму інтерстиціальної тканини поряд зі зменшенням обсягу фолікулів. Виявлені особливості свідчать про внутрішньоутробне функціональне перенапруження яєчників плодів від матерів, вагітність у яких ускладнена еклампсією. Гістологічна будова органу відповідає гіперпластичному типу. Описані зміни у відповідності з даними літератури є ознакою полігландулярної ендокринопатії у плодів від матерів з еклампсією і у подальшому онтогенезі можуть сприяти порушенню гермінативної і ендокринної функцій організму.The complex investigation of the ovaries of the fetuses from the mothers whose pregnancy was complicated by eclampsia revealed a signifcant reduction of the organ mass and size as compared to those in the control group, an increase of the relative volume of the interstitial tissue, and a reduction of the follicle volume. The revealed changes suggest an intrauterine functional overstrain of the fetal ovaries from the mothers whose pregnancy was complicated by eclampsia. The histology fndings of the organ corresponded to the hyperplastic type. According to the literature, the aforementioned changes are the signs of polyglandularendocrinopathy in fetuses from mothers with eclampsia; in the further ontogenesis, they can promote disorders of the germentative and endocrine functions of the organism

Quantifying human genome parameters in aging

Healthy human longevity is a global goal of the world health system. Determining the causes and processes influencing human longevity is the primary fundamental goal facing the scientific community. Currently, the main efforts of the scientific community are aimed at identifying the qualitative characteristics of the genome that determine the trait. At the same time, when evaluating qualitative characteristics, there are many challenges that make it difficult to establish associations. Quantitative traits are burdened with such problems to a lesser extent, but they are largely overlooked in current genomic studies of aging and longevity. Although there is a wide repertoire of quantitative trait analyses based on genomic data, most opportunities are ignored by authors, which, along with the inaccessibility of published data, leads to the loss of this important information. This review focuses on describing quantitative traits important for understanding aging and necessary for analysis in further genomic studies, and recommends the inclusion of the described traits in the analysis. The review considers the relationship between quantitative characteristics of the mitochondrial genome and aging, longevity, and age-related neurodegenerative diseases, such as the frequency of extensive mitochondrial DNA (mtDNA) deletions, mtDNA half-life, the frequency of A>G replacements in the mtDNA heavy chain, the number of mtDNA copies; special attention is paid to the mtDNA methylation sign. A separate section of this review is devoted to the correlation of telomere length parameters with age, as well as the association of telomere length with the amount of mitochondrial DNA. In addition, we consider such a quantitative feature as the rate of accumulation of somatic mutations with aging in relation to the lifespan of living organisms. In general, it may be noted that there are quite serious reasons to suppose that various quantitative characteristics of the genome may be directly or indirectly associated with certain aspects of aging and longevity. At the same time, the available data are clearly insufficient for definitive conclusions and the determination of causal relationships

Light scattering and localization in an ultracold and dense atomic system

The quantum optical response of high density ultracold atomic systems is critical to a wide range of fundamentally and technically important physical processes. These include quantum image storage, optically based quantum repeaters and ultracold molecule formation. We present here a microscopic analysis of the light scattering on such a system, and we compare it with a corresponding description based on macroscopic Maxwell theory. Results are discussed in the context of the spectral resonance structure, time-dependent response, and the light localization problem